| 2. |
- Ljungström, Inger, 1944-
(author)
-
Trichinella spiralis : formation of specific antibodies and modulation of the immune response
- 1979
-
Doctoral thesis (other academic/artistic)abstract
- The present study showed that Trichinella spiralis infection in human induced a specific antibody response including antibodies of IgM, IgA and IgG classes. Reactive sera were demonstrated from day 10 up to 2 years after onset of clinical symtoms. Experimental trichinosis resulted in cortical depletion of thymus and increased cell proliferation in T cell dependent and independent areas of spleen and lymph nodes during the early stage of infection. The capacity of the host to respond to an unrelated T cell dependent antigen given orally during the intestinal stage, was almost abolished at the local level in intestine, whereas the systemic response was depressed. Parenteral administration or oral immunization with unrelated T cell dependent antigens during the extraintestinal stage resulted in a depressed systemic antibody response. The humoral response to an unrelated T cell independent antigen was increased. Cellular immunity, measured as split heart allograft rejection, was depressed and the prolonged survival time was most pronounced during the intestinal stage. Spleen cell reactivity to polyclonal T cell activators and allogeneic stimulation was decreased and again the depression was most marked during the intestinal stage. Thus, T.spiralis infection profoundly affected the T cells during the intestinal stage and some depressive effects were observed also during the extraintestinal stage. T.spiralis infection enhanced the cholera toxin induced diarrhoea during the intestinal stage. This could probably be explained by the decreased absorption observed during the same period of infection. During the migration stage the intestinal secretory response to the enterotoxin was decreased. As the intestinal absorption was normal at this time the reduced fluid accumulation probably reflected a true inhibition of the secretory response.
|
|
