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Search: WFRF:(Lok Christianne)

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1.
  • Damoiseaux, David, et al. (author)
  • Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding : Results From a Case Series.
  • 2022
  • In: Clinical Pharmacology and Therapeutics. - : John Wiley & Sons. - 0009-9236 .- 1532-6535. ; 112:2, s. 404-410
  • Journal article (peer-reviewed)abstract
    • Little is known about infant's safety of chemotherapy during breastfeeding where evidence is limited to a few case reports. This lack of knowledge has led to a general tendency to advise against breastfeeding during cytotoxic therapy despite the overwhelming benefits that breastfeeding offers to both the mothers and their children. In this case series, the presence of five chemotherapies in breast milk was determined. The aim was to obtain insight into the presence of these drugs in breast milk to inform and help clinicians in making informed decisions for women who want to breastfeed. Three patients collected 24-hour samples of breast milk every day for 1, 2, or 3 weeks after chemotherapy, 210 in total. After determination of drug concentrations, the infant daily dose, relative daily infant dose (RID%) and cumulative RID were calculated. Cumulative RIDs in patients varied from 10% to values lower than 1%. Rich data allowed us to design a table which gives predictions on the amount of days that breast milk has to be discarded to reach cumulative RIDs below 5, 1, and 0.1% for each compound. For cyclophosphamide, paclitaxel, and carboplatin, cumulative RIDs below 1 or 0.1% are reached if breast milk is discarded for 1-3 days after administration. This might suggest that breastfeeding in between cycles is an option. However, other pharmacological parameters should also be taken into consideration. For doxorubicin, also the levels of the active metabolite doxorubicinol need quantification. Similarly, breastfeeding during treatment with cisplatin might give substantial exposure and we advise caution.
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2.
  • In ’t Veld, Sjors G.J.G., et al. (author)
  • Detection and localization of early- and late-stage cancers using platelet RNA
  • 2022
  • In: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 40:9, s. 999-1009.e6
  • Journal article (peer-reviewed)abstract
    • Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Griffioen, Arjan W. (1)
Verdonck-de Leeuw, I ... (1)
Teunissen, Charlotte ... (1)
Roos, Eva (1)
Christensen, Ib J. (1)
Meijers-Heijboer, Ha ... (1)
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Borgfeldt, Christer (1)
Kalapotharakos, Grig ... (1)
Besselink, Marc G. (1)
Wurdinger, Thomas (1)
Tannous, Bakhos A (1)
Bahce, Idris (1)
Smit, Egbert F (1)
Sundfeldt, Karin, 19 ... (1)
Lokhorst, Henk (1)
Sol, Nik (1)
Ylstra, Bauke (1)
Dorsman, Josephine (1)
Reijneveld, Jaap C (1)
Wesseling, Pieter (1)
Best, Myron G. (1)
Tannous, Jihane (1)
Westerman, Bart A. (1)
Verschueren, Heleen (1)
Post, Edward (1)
Verheul, Henk M. (1)
Noske, David P. (1)
Nilsson, R. Jonas A. (1)
Vancura, Adrienne (1)
Muller, Mirte (1)
Niemeijer, Anna-Lari ... (1)
Tjon Kon Fat, Lee-An ... (1)
Meijer, Laura L. (1)
Wedekind, Laurine E. (1)
Kazemier, Geert (1)
Giovannetti, Elisa (1)
Idema, Sander (1)
Killestein, Joep (1)
Heger, Michal (1)
de Jager, Saskia C. (1)
Pasterkamp, Gerard (1)
Bogaard, Harm-Jan (1)
Vandertop, W. Peter (1)
van den Broek, Daan (1)
Lee-Lewandrowski, El ... (1)
Lewandrowski, Kent B ... (1)
de Langen, Adrianus ... (1)
van den Heuvel, Mich ... (1)
Dorlo, Thomas P. C., ... (1)
Huitema, Alwin D R (1)
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University
University of Gothenburg (1)
Umeå University (1)
Uppsala University (1)
Lund University (1)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3)

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