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- Manousek, Jan, et al.
(author)
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Delayed-Type Hypersensitivity to Metals of Environmental Burden in Patients with Takotsubo Syndrome - Is There a Clinical Relevance?
- 2016
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:11
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Journal article (peer-reviewed)abstract
- Objective Takotsubo syndrome (TS) is a heart condition characterised by a sudden transient left ventricular dysfunction; its pathophysiology is probably associated with elevated levels of catecholamines but the exact mechanism is not known as yet. Literature and clinical experience suggest that TS affects persons with various comorbidities. This pilot work aims to evaluate the frequency of comorbidities with potential pathological immune reactivity, and to evaluate the potential association between TS and hypersensitivity to metals assessed by LTT-MELISA (R). Methodology, Results A total of 24 patients (23 women, 1 man) with a history of TS attack and 27 healthy controls were evaluated. Hypersensitivity was evaluated by a lymphocyte transformation test (LTT-MELISA (R)); a questionnaire of environmental burden was used to select evaluated metals. A total of 19 patients (79%) had at least one condition that might potentially be associated with pathological immune reactivity (autoimmune thyroid disease, drug allergy, bronchial asthma, cancer, contact dermatitis, rheumatoid arthritis). Hypersensitivity to metals was identified significantly more frequently in TS patients than in healthy controls (positive reaction to at least one metal was identified in 95.8% of TS patients and in 59.3% of controls; p = 0.003); the difference was statistically significant for mercury (45.8% and 14.8%, respectively; p = 0.029). Conclusion Our work shows that conditions with pathological immune reactivity occur frequently in TS patients, and our data suggest a possible association between TS and hypersensitivity tometals (mercury in particular) evaluated by LTT-MELISA (R). We also suggest that apart from the triggering stress factor, potential existence of other serious conditions should be considered when taking medical history of TS patients.
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| 2. |
- Sejkot, Petr, 1986-
(author)
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Úhelníky s prolisem ve spojích dřevěných prvků
- 2015
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Doctoral thesis (other academic/artistic)abstract
- The thesis deals with appropriate methods to determinate load-bearing capacities of timber structures joints using angle brackets with a rib. In these joints, annular ring nails were used as connectors.During an experimental approach, full-scale load tests of whole joints were performed. Their load-bearing capacity was evaluated according to the actual Standards.During an analytic approach, calculation procedures were determined to calculate load-bearing capacities of tested joints and used connectors – annular ring nails.During numerical approach, full-scale experiments of the joints were simulated in Abaqus CAE software.To sum up, results according to these three methods are directly compared in the thesis. Moreover, thanks to the calculation methods validated in this thesis, the BOVA Březnice Ltd. changed the geometry of produced metal works and significantly improved its load-bearing capacities.
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