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1.	Lutjohann, D, et al. (author) First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods 2019 In: The Journal of steroid biochemistry and molecular biology. - : Elsevier BV. - 1879-1220 .- 0960-0760. ; 190, s. 115-125 Journal article (peer-reviewed)
2.	Abu-Hayyeh, S., et al. (author) Prognostic and Mechanistic Potential of Progesterone Sulfates in Intrahepatic Cholestasis of Pregnancy and Pruritus Gravidarum 2016 In: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 63:4, s. 1287-1298 Journal article (peer-reviewed)abstract A challenge in obstetrics is to distinguish pathological symptoms from those associated with normal changes of pregnancy, typified by the need to differentiate whether gestational pruritus of the skin is an early symptom of intrahepatic cholestasis of pregnancy (ICP) or due to benign pruritus gravidarum. ICP is characterized by raised serum bile acids and complicated by spontaneous preterm labor and stillbirth. A biomarker for ICP would be invaluable for early diagnosis and treatment and to enable its differentiation from other maternal diseases. Three progesterone sulfate compounds, whose concentrations have not previously been studied, were newly synthesized and assayed in the serum of three groups of ICP patients and found to be significantly higher in ICP at 9-15 weeks of gestation and prior to symptom onset (group 1 cases/samples: ICP n = 35/80, uncomplicated pregnancy = 29/100), demonstrating that all three progesterone sulfates are prognostic for ICP. Concentrations of progesterone sulfates were associated with itch severity and, in combination with autotaxin, distinguished pregnant women with itch that would subsequently develop ICP from pruritus gravidarum (group 2: ICP n = 41, pruritus gravidarum n = 14). In a third group of first-trimester samples all progesterone sulfates were significantly elevated in serum from low-risk asymptomatic women who subsequently developed ICP (ICP/uncomplicated pregnancy n = 54/51). Finally, we show mechanistically that progesterone sulfates mediate itch by evoking a Tgr5-dependent scratch response in mice. Conclusion: Our discovery that sulfated progesterone metabolites are a prognostic indicator for ICP will help predict onset of ICP and distinguish it from benign pruritus gravidarum, enabling targeted obstetric care to a high-risk population. Delineation of a progesterone sulfate-TGR5 pruritus axis identifies a therapeutic target for itch management in ICP.
3.	Adamson, L, et al. (author) Enhanced IL-12 production and T cell stimulation ability by dendritic cells matured in presence of GMP-grade Toll-like receptor ligands and IFN-gamma 2016 In: CANCER IMMUNOLOGY RESEARCH. - 2326-6066. ; 4:1 Conference paper (other academic/artistic)
4.	Agerso, H, et al. (author) Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients. 2004 In: Br J Clin Pharmacol.. ; 58:4, s. 352-8 Journal article (peer-reviewed)
5.	Arrhen, YM, et al. (author) A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction 2013 In: British journal of clinical pharmacology. - : Wiley. - 1365-2125 .- 0306-5251. ; 75:6, s. 1536-1540 Journal article (peer-reviewed)
6.	Bartholdson, C, et al. (author) BEREAVED MOTHERS' AND FATHERS' PERCEPTIONS OF COMMUNICATION ABOUT THEIR CHILD'S CANCER DIAGNOSIS AND WHEN THE ILLNESS BECAME INCURABLE - A POPULATION-BASED NATIONWIDE SURVEY 2022 In: PEDIATRIC BLOOD & CANCER. - 1545-5009. ; 69, s. S531-S531 Conference paper (other academic/artistic)
7.	Bjorkhem, I, et al. (author) High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction? 2011 In: Journal of lipid research. - 1539-7262. ; 52:1, s. 170-174 Journal article (peer-reviewed)
8.	Bjorkhem, I, et al. (author) On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO 2014 In: Journal of lipid research. - 1539-7262. ; 55:6, s. 1165-1172 Journal article (peer-reviewed)
9.	Heverin, M, et al. (author) Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol 2007 In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 27:10, s. 2191-2197 Journal article (peer-reviewed)
10.	Jalmsell, Li, et al. (author) They want the Truth while Still Being Allowed to Hope - An Interview Study with Severely Ill Children on Receiving Bad News 2015 In: PEDIATRIC BLOOD & CANCER. - 1545-5009. ; 62, s. S347-S347 Conference paper (other academic/artistic)

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Result 1-10 of 19

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Type of publication: journal article (13); conference paper (6)

Type of content: peer-reviewed (11); other academic/artistic (8)

Author/Editor: Lovgren-Sandblom, A. (10); Bjorkhem, I (7); Diczfalusy, U (7); Kreicbergs, U (5); Lovgren, M (5); Griffiths, WJ (3); show more...; Lovgren, T (3); Jalmsell, Li (3); Wang, YQ (3); Leoni, V (3); Crick, PJ (3); McDonald, J. (2); Abu-Hayyeh, S (2); Williamson, C (2); Ovadia, C. (2); Chambers, J. (2); Bolier, R. (2); Tolenaars, D. (2); Beuers, U. (2); Oude-Elferink, R. (2); Lutjohann, D (2); Heverin, M (2); Adamson, L (2); Lundqvist, A (2); Kiessling, R (2); Nystrom, M (2); Edback, U (2); Iuliano, L (2); Sveen, J (2); Nunes, VS (2); Bretillon, L (2); Browne, RW (2); Friedrichs, S (2); Fauler, G. (2); Schmitz, G (2); Kerksiek, A (2); Geilenkeuser, WJ (2); Ansorena, D (2); Astiasaran, I (2); Baila-Rueda, L (2); Barriuso, B (2); Caccia, C (2); Cenarro, A (2); Garcia-Llatas, G (2); Lagarda, MJ (2); Lottenberg, AM (2); Matysik, S (2); Rideout, TC (2); Zerbinati, C (2); Schott, HF (2); show less...

University: Karolinska Institutet (18); Uppsala University (4); University of Gothenburg (2); Linnaeus University (1)

Language: English (19)

Research subject (UKÄ/SCB): Medical and Health Sciences (6)

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