| 1. |
- Albertsson-Wikland, Kerstin, 1947, et al.
(author)
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Growth hormone dose-dependent pubertal growth : a randomized trial in short children with low growth hormone secretion
- 2014
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In: Hormone Research in Paediatrics. - : S. Karger AG. - 1663-2818 .- 1663-2826. ; 82:3, s. 158-170
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Journal article (peer-reviewed)abstract
- Background/Aims: Growth hormone (GH) treatment regimens do not account for the pubertal increase in endogenous GH secretion. This study assessed whether increasing the GH dose and/or frequency of administration improves pubertal height gain and adult height (AH) in children with low GH secretion during stimulation tests, i. e. idiopathic isolated GH deficiency.Methods: A multicenter, randomized, clinical trial (No. 88-177) followed 111 children (96 boys) at study start from onset of puberty to AH who had received GH(33) mu g/kg/day for >= 1 year. They were randomized to receive 67 mu g/kg/day (GH(67)) given as one (GH(67x1); n = 35) or two daily injections (GH(33x2); n = 36), or to remain on a single 33 mu g/kg/day dose (GH(33x1); n = 40). Growth was assessed as height SDS gain for prepubertal, pubertal and total periods, as well as AH SDS versus the population and the midparental height.Results: Pubertal height SDS gain was greater for patients receiving a high dose (GH(67), 0.73) than a low dose (GH(33x1), 0.41, p < 0.05). AH(SDS) was greater on GH(67) (GH(67x1), -0.84; GH(33x2), -0.83) than GH(33) (-1.25, p < 0.05), and height SDS gain was greater on GH(67) than GH(33) (2.04 and 1.56, respectively; p < 0.01). All groups reached their target height SDS.Conclusion: Pubertal height SDS gain and AH SDS were dose dependent, with greater growth being observed for the GH(67) than the GH(33) randomization group; however, there were no differences between the once-and twice-daily GH(67) regimens. (C) 2014 S. Karger AG, Basel.
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| 2. |
- de Vries, Charlotte, et al.
(author)
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Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction
- 2022
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In: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 11:4
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Journal article (peer-reviewed)abstract
- There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria Porphyromonas gingivalis (Pg) as one of the key drivers of periodontitis, we set out to investigate whether antibodies to Pg virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls (p < 0.0001), in individuals positive for anti-citrullinated protein antibodies (p = 0.04) and anti-dsDNA antibodies (p = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls (p = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations.
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| 3. |
- Froitzheim, Jan, 1981, et al.
(author)
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Nano coated interconnects for SOFC (NaCoSOFC)
- 2013
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In: ECS Transactions. - : The Electrochemical Society. - 1938-5862 .- 1938-6737. ; 57:1, s. 2187-2193
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Conference paper (peer-reviewed)abstract
- The NaCoSOFC project is focused on the development of nano coatings for SOFC interconnects. The project is sponsored by the Nordic Top Level Research Initiative and has four project partners: Sandvik Materials Technology which is producing coated interconnects, Chalmers University of Technology and the University of Oslo that characterize samples with respect to e.g. corrosion, Cr evaporation and ASR as well as Topsoe Fuel Cell that is testing the developed interconnects in its stacks. The developed coatings are based on a combination of Co with RE elements and exhibit high corrosion resistance, 10 fold decrease in Cr evaporation and ASR values that are approximately 50% of the uncoated material.
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| 4. |
- Goebel, Claudia, 1988, et al.
(author)
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Long term (4 years) performance of Co/Ce coated 441 for SOFC interconnect applications
- 2017
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In: ECS Transactions. - : The Electrochemical Society. - 1938-5862 .- 1938-6737. ; 78:1, s. 1675-1679
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Conference paper (peer-reviewed)abstract
- Co/Ce coated 441 samples were exposed at 800°C in laboratory air for up to 37 000 h and subsequently characterized using different techniques. Mass gain data of all samples were recorded throughout exposure. Cr-evaporation measurements were conducted and compared with unexposed Co/Ce coated AISI 441 as well as unexposed and uncoated AISI 441. Furthermore SEM analysis on BIB cross-sections was performed on 7 000 h, 23 000 h and 35 000 h exposed Co/Ce coated 441.
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| 5. |
- Hedner, Jan A, 1953, et al.
(author)
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Effects of TRH and TRH analogues on the central regulation of breathing in the rat.
- 1983
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In: Acta physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 117:3, s. 427-37
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Journal article (peer-reviewed)abstract
- Respiratory activity was studied in rats during light halothane anesthesia. Thyrotropin releasing hormone (TRH) and two TRH analogues: the desamidated form (TRH-OH) and gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate (DN 1417) were administered intracerebroventricularly. TRH 0.5-5 micrograms induced a marked tachypnoea with a rapid onset and a duration of at least 20 min. DN 1417, a potent analogue of TRH with a very low TSH (thyroid stimulating hormone) releasing activity was more effective in stimulating respiratory frequency, while TRH-OH, regarded to have neither TSH releasing nor extra hypothalamic effects, at equimolar doses was unable to induce any changes in the respiratory pattern. When TRH was given into the fourth ventricle the dose response curve was slightly shifted to the left. In experiments employing the occluded breath technique, P0.1 was increased in the same magnitude as the mean inspiratory flow (VT/T1). The results also indicated an increase in the gain of the inflation reflex loop whereas the central bulbopontine setting for T1 and TTOT were not significantly changed. Local injection of TRH into the nucleus tractus solitarii induced a stimulation of respiratory frequency which was slower in onset compared to the response seen after injection into the lateral or fourth ventricles. Concomitantly to the respiratory changes, i.c.v. TRH injection induced a hypocarbia and an alkalosis. No changes in blood pressure or heart rate were seen. The respiratory stimulant effect of TRH could be potentiated by pretreatment with naloxone, methylatropine or a low dose of GABA. Haloperidol or propranolol did not significantly change the respiratory effects of TRH, while reserpine pretreatment seemed to blunt some of the ventilatory effects of TRH. It seems likely that TRH has few direct effects on brain stem neurones involved in the central regulation of respiration, but the main effects seem to be elicited in areas rostral to the brain stem. The respiratory stimulating effect of TRH is unrelated to TSH. Furthermore, other neurotransmitter systems might also be involved in modulation of the respiratory stimulation evoked by TRH.
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| 6. |
- Lundberg, Jan, et al.
(author)
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High-speed video photographs of lubrication breakdown in squeeze-sliding contact
- 1992
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In: Wear. - 0043-1648 .- 1873-2577. ; 157:2, s. 427-433
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Journal article (peer-reviewed)abstract
- Using photographs from a high-speed video camera it was confirmed that the main part of breakdown of a lubricating film will appear at the end of the contact time for a contact simultaneously subjected to squeeze and sliding motion. This corresponds with earlier findings using totally different equipment for electric detection of the asperity contact. The present investigation used glass and steel as the lubricated surfaces, instead of steel and steel as was the case in the earlier investigation. In combination with far less stiff equipment, the new materials gave longer contact time and larger elastic deformations of the contact bodies. It was also verified that increased surface roughness, increased sliding velocity and decreased viscosity increase the risk of oil film breakdown
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| 7. |
- Lundberg, Rebecca, et al.
(author)
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Perinatal exposure to PCB 153, but not PCB 126, alters bone tissue composition in female goat offspring
- 2006
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In: Toxicology. - : Elsevier BV. - 0300-483X .- 1879-3185. ; 228:1, s. 33-40
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Journal article (peer-reviewed)abstract
- The aim of this study was to investigate if environmentally relevant doses of the putative estrogenic non dioxin-like PCB 153 and the dioxin-like PCB 126 caused changes in bone tissue in female goat offspring following perinatal exposure. Goat dams were orally dosed with PCB 153 in corn oil (98 microg/kg body wt/day) or PCB 126 (49 ng/kg body wt/day) from day 60 of gestation until delivery. The offspring were exposed to PCB in utero and through mother's milk. The suckling period lasted for 6 weeks. Offspring metacarpal bones were analysed using peripheral quantitative computed tomography (pQCT) after euthanisation at 9 months of age. The diaphyseal bone was analysed at a distance of 18% and 50% of the total bone length, and the metaphyseal bone at a distance of 9%. Also, biomechanical three-point bending of the bones was conducted, with the load being applied to the mid-diaphyseal pQCT measure point (50%). PCB 153 exposure significantly decreased the total cross-sectional area (125 mm(2)+/-4) versus non-exposed (142 mm(2)+/-5), decreased the marrow cavity (38 mm(2)+/-4) versus non-exposed (50 mm(2)+/-3) and decreased the moment of resistance (318 mm(3)+/-10) versus non-exposed (371 mm(3)+/-20) at the diaphyseal 18% measure point. At the metaphyseal measure point, the trabecular bone mineral density (121 mg/cm(3)+/-5) was increased versus non-exposed (111 mg/cm(3)+/-3). PCB 126 exposure did not produce any observable changes in bone tissue. The biomechanical testing of the bones did not show any significant changes in bone strength after PCB 153 or PCB 126 exposure. In conclusion, perinatal exposure to PCB 153, but not PCB 126, resulted in altered bone composition in female goat offspring.
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| 8. |
- Nykänen, Arne, et al.
(author)
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Modelling perceptual dimensions of saxophone sounds
- 2009
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In: Acta Acoustica united with Acustica. - 1610-1928 .- 1861-9959. ; 95:3, s. 539-549
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Journal article (peer-reviewed)abstract
- In the past, musical instruments were developed over long periods of time by skilled craftsmen. Today, most instruments are mass-produced. Design of musical instruments as mass-produced products requires using strategies which make it easier to identify customer needs and develop exact specifications. To develop useful specifications it is necessary to convert general descriptions into something which can be commonly understood and also be interpretable in terms of acoustic metrics. In this study, methods for analysis and specification of steady state parts of alto saxophone sounds were developed. Saxophonists' use of verbal descriptions of saxophone sounds was investigated. Sound stimuli were binaurally recorded. Judgements upon perceived qualities were made by saxophonists and non-saxophonists using the method of verbal attribute magnitude estimation. Perceptual dimensions were identified using principal component analysis of listening test data. Three prominent dimensions were found and described using the verbal attributes: 1) warm/soft, 2) back vowel analogues and 3) sharp/rough. The perceptual dimensions were modelled as linear functions of acoustic metrics. The results were validated through listening tests with new subjects and new stimuli. Based on the findings, the method was seen as an approach which can enhance the musical instrument design process.
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| 9. |
- Nykänen, Arne, et al.
(author)
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Perceptual and acoustical dimensions of saxophone sound
- 2005
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In: Forum Acusticum Budapest 2005, 4th European Congress on Acoustics. ; , s. 519-524
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Conference paper (peer-reviewed)abstract
- Specifications of product sound qualities may contain both perceptual and acoustical descriptions. The perceptual descriptions are most helpful when they contain adequate detail and utilises understandable wording. To facilitate the product design process the descriptions should also be interpretable as acoustical quantities. The objectives of the study reported upon here were to investigate how musicians use verbal descriptions of sound and to interpret these descriptions in terms of commonly used acoustical quantities. Musicians' use of verbal descriptions of saxophone sound was investigated through interviews. The most frequently used words were evaluated through listening tests. The subjects were asked to judge how well the words described the timbre of test sounds. To find the most significant perceptual dimensions for the test sounds Principal Component Analysis was used. Four significant dimensions were found and described by 9 words. To interpret the perceptual dimensions in terms of physically measurable indices, models for how acoustical quantities relate to the perceptual dimensions were developed. Dimension 1 was described by full-toned/warm/soft. The psycho-acoustical quantity sharpness correlated negatively with this dimension. Dimension 2 was described by the term [o]-like. Sharpness and specific roughness (9-11 Bark) correlated negatively with this dimension. Dimension 3 was described by sharp/keen/rough. Sharpness and roughness correlated with this dimension. Dimension 4 was described by the term [e]-like. No model for prediction of this dimension was found. To validate the models the effect of a changed design of the tone holes of a saxophone was predicted with the model and validated with new listening tests.
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| 10. |
- Skogberg, Gabriel, et al.
(author)
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Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.
- 2014
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In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 193:5, s. 2187-95
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Journal article (peer-reviewed)abstract
- Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and autoimmune diseases. Patients with DS share clinical features, such as autoimmune manifestations and specific autoantibodies, with patients affected by autoimmune polyendocrine syndrome type 1. Autoimmune polyendocrine syndrome type 1 is caused by mutations in the autoimmune regulator (AIRE) gene, located on chromosome 21, which regulates the expression of tissue-restricted Ags (TRAs) in thymic epithelial cells. We investigated the expression of AIRE and TRAs in DS and control thymic tissue using quantitative PCR. AIRE mRNA levels were elevated in thymic tissue from DS patients, and trends toward increased expression of the AIRE-controlled genes INSULIN and CHRNA1 were found. Immunohistochemical stainings showed altered cell composition and architecture of the thymic medulla in DS individuals with increased frequencies of AIRE-positive medullary epithelial cells and CD11c-positive dendritic cells as well as enlarged Hassall's corpuscles. In addition, we evaluated the proteomic profile of thymic exosomes in DS individuals and controls. DS exosomes carried a broader protein pool and also a larger pool of unique TRAs compared with control exosomes. In conclusion, the increased AIRE gene dose in DS could contribute to an autoimmune phenotype through multiple AIRE-mediated effects on homeostasis and function of thymic epithelial cells that affect thymic selection processes.
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