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Search: WFRF:(Lupinu Ilenia)

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  • Riu, Federico, et al. (author)
  • Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes : An Overview
  • 2022
  • In: Pharmaceuticals. - : MDPI AG. - 1424-8247. ; 15:8
  • Research review (peer-reviewed)abstract
    • Certain bacteria constitute a threat to humans due to their ability to escape host defenses as they easily develop drug resistance. Bacteria are classified into gram-positive and gram-negative according to the composition of the cell membrane structure. Gram-negative bacteria have an additional outer membrane (OM) that is not present in their gram-positive counterpart; the latter instead hold a thicker peptidoglycan (PG) layer. This review covers the main structural and functional properties of cell wall polysaccharides (CWPs) and PG. Drugs targeting CWPs are discussed, both noncarbohydrate-related (β-lactams, fosfomycin, and lipopeptides) and carbohydrate-related (glycopeptides and lipoglycopeptides). Bacterial resistance to these drugs continues to evolve, which calls for novel antibacterial approaches to be developed. The use of carbohydrate-based vaccines as a valid strategy to prevent bacterial infections is also addressed.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Ruda, Alessandro, 19 ... (1)
Widmalm, Göran (1)
Ibba, Roberta (1)
Riu, Federico (1)
Sestito, Simona (1)
Piras, Sandra (1)
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Carta, Antonio (1)
Lupinu, Ilenia (1)
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University
Stockholm University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2022 (1)

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