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1.	Clausen, Niels, et al. (author) Similar bleeding phenotype in young children with haemophilia A or B : A cohort study 2014 In: Haemophilia. - : Wiley. - 1351-8216. ; 20:6, s. 747-755 Journal article (peer-reviewed)abstract The bleeding phenotype has been suggested to differ between haemophilia A and B. More knowledge on the bleeding phenotype at initiation of treatment is important to optimize patient care. The aim of this study was to investigate the severity of the bleeding phenotype and the variation in bleeding in children with severe or moderate haemophilia A and B. Consecutive, previously untreated patients with severe or moderate haemophilia A and B (factor VIII or IX activity <0.01 or 0.01-0.05 IU mL-1 respectively) born between January 1st 2000 and January 1st 2010 were included. Primary outcome was severity of bleeding tendency. Secondary outcome was variation in bleeding pattern. A total of 582 patients with severe haemophilia A and 76 with severe haemophilia B did not differ in age at first exposure to clotting factor (0.81 vs. 0.88 years, P = 0.20), age at first bleed (0.82 vs. 0.88 years, P = 0.36), and age at first joint bleed (1.18 vs. 1.20 years, P = 0.59). Patients with moderate haemophilia were older compared to patients with severe haemophilia. In patients with moderate haemophilia there were no clear differences between haemophilia A and B. Severity and variation in bleeding phenotype are similar during the early stage of treatment in patients with severe and moderate haemophilia A and B respectively. The findings imply that children with haemophilia B should be observed and treated as vigilantly as those with haemophilia A.
2.	Tuckuviene, R, et al. (author) Prospective study of thromboembolism in 1038 children with acute lymphoblastic leukemia - a Nordic Society of Pediatric Hematology and Oncology (NOPHO) study. 2016 In: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 14:3, s. 485-494 Journal article (peer-reviewed)abstract Thromboembolism (TE) is a major toxicity in children with acute lymphoblastic leukemia (ALL) and may have a negative impact on ALL treatment.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Mäkipernaa, A. (2); Williams, M (1); Fischer, K. (1); Clausen, Niels (1); Kurnik, K. (1); Carcao, M (1); show more...; Frisk, T (1); Tedgård, Ulf (1); Oldenburg, J (1); Albertsen, B. K. (1); Jonsson, O. G. (1); Ranta, S (1); Ljung, R (1); Kenet, G (1); Chambost, H (1); Chalmers, E (1); Escuriola, C (1); Kobelt, R (1); Liesner, R (1); Molinari, A (1); Muntean, W (1); Nolan, B (1); Platokouki, H (1); Rafowicz, A (1); Santagostino, E (1); Rivard, G (1); Helgestad, J (1); Pruunsild, K (1); Ruud, E (1); Tuckuviene, R (1); Altisent, C. (1); Peerlinck, K. (1); Petrini, P (1); van den Berg, H M (1); Kreuz, W. (1); Claeyssens-Donadel, ... (1); Gouw, S. C. (1); Auerswald, G. (1); Cid, A. (1); van Geet, Ch (1); Goethe, J. W. (1); Pérez Garrido, R. (1); Mancuso, M. E. (1); van der Bom, J. G. (1); Heyman, M M (1); Andersson, N G (1); Bendtsen, M D (1); Gunnes, M W (1); Trakymiene, S S (1); show less...

University: Lund University (2); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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