| 1. |
- Attauabi, Mohamed, et al.
(author)
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Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study) : the protocol for a Copenhagen IBD Inception Cohort Study
- 2022
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In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 12:6, s. e055779-e055779
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Journal article (peer-reviewed)abstract
- Introduction: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.Methods and analysis: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.Ethics and dissemination: This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences.
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| 2. |
- Grahn Kronhed, Ann-Charlotte, et al.
(author)
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The effect of short-term balance training on community-dwelling older adults
- 2001
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In: Journal of Aging and Physical Activity. - 1063-8652 .- 1543-267X. ; 9:1, s. 19-31
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Journal article (peer-reviewed)abstract
- This study evaluated a balance-training program's influence in healthy older adults. Fifteen community-dwelling participants aged 70Ð75 years were randomized to an exercise group, and 15 gender- and age-matched participants, to a control group. The 9-week training program comprised ordinary-life balance, vestibular-habituation, and ball exercises and station training. Clinical balance tests were conducted before and after training. Tests that showed significant improvement in the exercise group after the intervention included standing on the right leg with eyes closed, standing on the right leg and the left leg while turning the head and walking 30 m. Significant between-group differences were found at posttest. A significant decrease was seen in the control group in the walking-forward test, and this change was significantly different between groups. The study indicates that balance performance in healthy older adults might be improved by balance training including exercises that stimulate multiple sensory systems and their central integration.
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| 3. |
- Gustavsson, Ann-Sofi, et al.
(author)
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Changes in balance performance in physically active elderly people aged 73-80
- 2000
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In: Scandinavian Journal of Rehabilitation Medicine. - : Informa UK Limited. - 0036-5505 .- 1940-2228. ; 32:4, s. 168-172
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Journal article (peer-reviewed)abstract
- In our hospital in 1989 a series of 30 healthy elderly people participated in a study to evaluate the effect of physical training on improving balance. Thereafter, the majority of the people in this group continued with some kind of balance training. Seven years later we followed up 17 of the people who had participated in the original study. We wanted to evaluate the balance performance of these physically active elderly people (mean age 80.5 years) and compare it with their balance performance 7 years previously. Balance was found to be significantly impaired compared with 1989 in four out of six static balance tests. The time required to walk 30 m had increased significantly. The subjective ratings of vertigo and balance problems had not changed significantly, neither had the number of correct steps when walking forwards on one line and backwards between two lines. In dynamic posturography, the test with sway-referenced visual cues showed improved postural control, but no change in sway was seen in the other five sensory conditions. When sudden backward translations of the platform occurred, increased latencies of force response were seen.
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| 6. |
- Andersson, Jenny, et al.
(author)
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Zircon geochronology of migmatite gneisses along the Mylonite Zone (S Sweden): a major Sveconorwegian terrane boundary in the Baltic Shield
- 2002
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In: Precambrian Research. - 0301-9268. ; 114:1-2, s. 121-147
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Journal article (peer-reviewed)abstract
- The southern section of the Mylonite Zone (MZ) is a major lithotectonic terrane boundary in the SW Baltic Shield. It separates the parautochthonous Eastern Segment of the Sveconorwegian orogen from the allochthonous Western Segment. Complex zircons in migmatised and banded orthogneisses along the southern MZ were investigated by ion microprobe analyses guided by backscattered electron imaging to directly date the partial melting and associated penetrative ductile deformation in this zone. In the eastern part of the MZ (Eastern Segment), resorbed igneous zircon cores in stromatic orthogneiss are 1686 +/- 11 Ma old, whereas extensive overgrowths and abundant newly formed simple zircons are 969 +/- 13 Ma old. Migmatised K-feldspar megacrystic granite has 1359 +/- 26 Ma igneous protolith zircon cores and abundant 968 +/- 13 Ma overgrowths and simple grains. Both rock units contain amphibolitised mafic pods with remnants of garnet-clinopyroxene-bearing, high-pressure granulite facies parageneses. In the western part of the MZ (Western Segment), igneous protolith zircon cores in stromatic orthogneiss, are dated at 1585 +/- 11 Ma and abundant new growth of zircon at 980 +/- 13 Ma. Enclosed mafic rocks have middle amphibolite facies parageneses. Secondary zircon in all three samples occurs as distinct, sub-idiomorphic overgrowths or as simple crystals with low Th/U ratios ( < 0.07). The morphology and high modal abundance of secondary zircon (25-50% of the total volume of zircon), the absence of early- or pre-Sveconorwegian secondary zircon, and field relations provide evidence for that anatexis and associated penetrative ductile deformation in the southern MZ took place between 980 +/- 13 and 968 +/- 13 Ma. These late-Sveconorwegian ages contradict previous interpretations of a pre-1.55 Ga age for the principal penetrative ductile deformation and stromatic layering of orthogneisses along the southern MZ. As a consequence, the role of the MZ as an important amalgamation zone for crustal growth in the Baltic Shield during the 1.70-1.55 Ga Gothian orogeny is questioned. Instead, the new data suggest that the MZ is a major Sveconorwegian lithologic and metamorphic terrane boundary along which middle-amphibolite facies supracrustals and orthogneisses of the Western Segment (protolith ages: 1.64-1.58 Ga) were juxtaposed against high-pressure granulite to upper-amphibolite facies orthogneisses of the Eastern Segment (protolith ages: 1.70-1.66 Ga) in late Sveconorwegian time. By implication, the pre-Sveconorwegian relation between crustal units west of the MZ and the margin of continent Baltica remains to be established. Understanding of the late Sveconorwegian tectonic evolution, particularly the amount of displacement along the MZ, is therefore, a pre-requisite for modelling the early and pre-Sveconorwegian tectonic evolution and crustal block configurations in the SW Baltic Shield.
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| 7. |
- Angbratt, Marianne, et al.
(author)
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Calcium intake in a Swedish adult population : relationship to life-style factors and bone mineral density. A descriptive study
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Other publication (other academic/artistic)abstract
- Background. This study is part of a community-based intervention programme dealing with the prevention of osteoporosis. The study aims were to estimate the calcium intake from dairy products and calcium supplements within a general population, and thereafter to study associations between calcium intake, relevant lifestyle factors, and forearm bone mineral density.Methods. A randomised sample of 15 % of the inhabitants aged 20 - 79 years ( = 1510) from two Swedish municipalities answered a questionnaire, and a selected sub-sample (n=448) had their forearm bone mineral density measured.Results. The mean consumption of calcium from dairy products was 878 mg/day. Men consumed more than women, and calcium intake decreased with increasing age. Twelve percent of the youngest age group in the study population and 31 % of the oldest age group did not meet the recommended daily intake. Associations were found between calcium intake and both residence and physical activity. There was a tendency towards an association between calcium intake and forearm bone mineral density. No other associations with lifestyle factors were observed.Conclusion. Calcium intake is in general well attained in an adult Swedish population, although the intake range is wide (55 to 3213 mg/day from dairy products). Women aged 50-59 years and older people are at increased risk of not meeting the recommended daily intake.
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| 8. |
- Arellano, Santiago, 1981, et al.
(author)
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Synoptic analysis of a decade of daily measurements of SO2 emission in the troposphere from volcanoes of the global ground-based Network for Observation of Volcanic and Atmospheric Change
- 2021
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In: Earth System Science Data. - : Copernicus GmbH. - 1866-3516 .- 1866-3508. ; 13:3, s. 1167-1188
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Journal article (peer-reviewed)abstract
- Volcanic plumes are common and far-reaching manifestations of volcanic activity during and between eruptions. Observations of the rate of emission and composition of volcanic plumes are essential to recognize and, in some cases, predict the state of volcanic activity. Measurements of the size and location of the plumes are important to assess the impact of the emission from sporadic or localized events to persistent or widespread processes of climatic and environmental importance. These observations provide information on volatile budgets on Earth, chemical evolution of magmas, and atmospheric circulation and dynamics. Space-based observations during the last decades have given us a global view of Earth's volcanic emission, particularly of sulfur dioxide (SO2). Although none of the satellite missions were intended to be used for measurement of volcanic gas emission, specially adapted algorithms have produced time-averaged global emission budgets. These have confirmed that tropospheric plumes, produced from persistent degassing of weak sources, dominate the total emission of volcanic SO2. Although space-based observations have provided this global insight into some aspects of Earth's volcanism, it still has important limitations. The magnitude and short-term variability of lower-atmosphere emissions, historically less accessible from space, remain largely uncertain. Operational monitoring of volcanic plumes, at scales relevant for adequate surveillance, has been facilitated through the use of ground-based scanning differential optical absorption spectrometer (ScanDOAS) instruments since the beginning of this century, largely due to the coordinated effort of the Network for Observation of Volcanic and Atmospheric Change (NOVAC). In this study, we present a compilation of results of homogenized post-analysis of measurements of SO2 flux and plume parameters obtained during the period March 2005 to January 2017 of 32 volcanoes in NOVAC. This inventory opens a window into the short-term emission patterns of a diverse set of volcanoes in terms of magma composition, geographical location, magnitude of emission, and style of eruptive activity. We find that passive volcanic degassing is by no means a stationary process in time and that large sub-daily variability is observed in the flux of volcanic gases, which has implications for emission budgets produced using short-term, sporadic observations. The use of a standard evaluation method allows for intercomparison between different volcanoes and between ground- and space-based measurements of the same volcanoes. The emission of several weakly degassing volcanoes, undetected by satellites, is presented for the first time. We also compare our results with those reported in the literature, providing ranges of variability in emission not accessible in the past. The open-access data repository introduced in this article will enable further exploitation of this unique dataset, with a focus on volcanological research, risk assessment, satellite-sensor validation, and improved quantification of the prevalent tropospheric component of global volcanic emission. Datasets for each volcano are made available at https://novac.chalmers.se (last access: 1 October 2020) under the CC-BY 4 license or through the DOI (digital object identifier) links provided in Table 1.
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| 9. |
- Beckman, Victoria, et al.
(author)
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Metamorphic zircon formation at the transition from gabbro to eclogite in Trollheimen-Surnadalen, Norwegian Caledonides
- 2014
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In: Geological Society Special Publication. - 2041-4927. ; 390, s. 403-424
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Journal article (peer-reviewed)abstract
- A transition from gabbro to eclogite has been investigated at Vinddoldalen in south-central Norway, with the aim to link reaction textures to metamorphic zircon growth and to obtain a direct U-Pb zircon age of the metamorphic process. In the different rocks of the transition zone zircon occurs as (I) igneous prismatic grains, (II) metamorphic polycrystalline rims and pseudomorphs after baddeleyite, and (III) as tiny (< 10 mu m) bead-like zircon grains. Textural relations suggest that type II zircon formed by breakdown of baddeleyite in the presence of silica, whereas Fe-Ti oxides were the main Zr source for the type III zircon. Subsolidus liberation of Zr and formation of bead zircon took place by oxyexsolution of titanomagnetite during fluid-assisted metamorphism, and by resorption of Fe-Ti oxide in rock domains that were completely recrystallized to eclogite. SIMS (secondary ion mass spectrometry) and TIMS (thermal ionization mass spectrometry) dating provides comparable U-Pb ages of magmatic zircon and baddeleyite. Baddeleyite (TIMS) yielded an age of 1457 +/- 11 Ma for the gabbro emplacement. Bead-type metamorphic zircon from eclogite gave 425 +/- 10 Ma (TIMS) dating the metamorphic transition from gabbro to eclogite in the upper basement of the Lower Allochthon in the south-central Scandinavian Caledonides.
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| 10. |
- Beckman, Victoria, et al.
(author)
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Prograde metamorphic zircon formation in gabbroic rocks : The tale of microtextures
- 2018
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In: Journal of Metamorphic Geology. - : Wiley. - 0263-4929. ; 36:9, s. 1221-1236
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Journal article (peer-reviewed)abstract
- U–Pb zircon dates of metagabbroic rocks, such as eclogite, mafic granulite, and garnet amphibolite, are used to constrain the timing of tectonometamorphic evolution in orogens worldwide. For such interpretation, however, it is imperative to define at which stage of the P–T evolution that zircon crystallization took place: the prograde, peak, or retrograde stage. In order to accurately interpret metamorphic zircon ages, it is necessary to assess how the zircon crystallized or recrystallized, as zircon can dissolve or grow under different metamorphic conditions. Zircon is robust to retrograde isotopic resetting under most crustal conditions, but equilibrium Zr mass balance models have suggested that zircon is largely produced during retrograde metamorphism. This study takes a textural approach and identifies and reviews zircon-forming textures and reactions in gabbro and metagabbro at different metamorphic grades, ranging from subgreenschist to upper amphibolite- and eclogite-facies, and at different stages of metamorphic recrystallization. The textural relationships demonstrate that, in metagabbro, metamorphic zircon grows during the early stage of metamorphic recrystallization, independent of pressure and temperature. The mode of zircon formation is remarkably similar throughout different stages of metamorphic recrystallization, and the most significant source of Zr is igneous baddeleyite. Hence, in contrast to the equilibrium mass balance model, most zircon in metagabbro forms by prograde metamorphic reactions that consume igneous phases, and not by late retrograde reactions, and the onset of zircon forming reactions is governed primarily by the introduction of a hydrous fluid, commonly accompanied by ductile deformation.
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