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| 2. |
- Stanaway, Jeffrey D., et al.
(author)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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In: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Journal article (peer-reviewed)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 3. |
- Kardan, Azam, et al.
(author)
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Interpretation of normal-deformed bands in Lu 167
- 2020
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In: Physical Review C. - 2469-9985. ; 101:1
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Journal article (peer-reviewed)abstract
- With the aim to get a general understanding of rotational bands in the deformed rare-earth region or in deformed nuclei in general, the observed normal-deformed rotational structures in Lu167 are interpreted within the unpaired and paired cranked Nilsson-Strutinsky formalisms, cranked Nilsson-Strutinsky and cranked Nilsson-Strutinsky-Bogoliubov. Particular attention is devoted to the band crossings. For this nucleus with the Fermi surface high up in the h11/2 shell, we conclude that except for the paired AB and BC crossings in configurations with an even and odd number of i13/2 neutrons, respectively, the observed band crossings can be understood within the unpaired formalism. Especially, it means that above the AB and BC crossings, the evolution with spin is described as a gradual alignment of the spin vectors of the particles outside closed shells. Consequently, the configurations can be characterized by the number of particles occupying open j shells or groups of j shells. In the present study, we revise the interpretation of some experimental bands and also the nature of the crossings while some previous configuration assignments are confirmed.
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| 4. |
- Ma, Hai-Liang, et al.
(author)
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Interpretation of the high spin states in Lu-161: A paired and unpaired study
- 2014
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In: Physical Review C (Nuclear Physics). - 0556-2813. ; 90:1
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Journal article (peer-reviewed)abstract
- A paired cranked Nilsson-Strutinsky-Bogoliubov (CNSB) model is presented, which employs the same method to calculate the liquid-drop energy and moment of inertia as the unpaired cranked Nilsson-Strutinsky (CNS) model. In the CNSB model, the energy minimization is carried out in the mesh of pairing gaps Delta and Fermi levels lambda as well as deformation parameters. The high spin states in Lu-161 are then investigated with the CNSB and CNS models. The terminating structure shows a striking similarity with these two models. Combining the CNSB and CNS models, a complete understanding of high spin structures, including the normal deformed (ND) and triaxial strongly deformed (TSD) bands and observed side bands in Lu-161, is achieved. It appears that the only important paired crossings are the first i(13/2) neutron crossing and the first h(11/2) proton crossing. For the description of the unpaired high spin crossings, it is important to be able to distinguish between the pseudospin partners in the proton N = 4 shell, (d(5/2), g(7/2)) and (d(3/2), s(1/2)). The yrast bands are predicted to terminate, which explains the structure of a TSD-like band X2. A band crossing at I approximate to 36.5 for the TSD band in Lu-161, unique within the chain of even-N Lu isotopes, is well described by the CNSB model.
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| 5. |
- Mahajan, Anubha, et al.
(author)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
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In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Journal article (peer-reviewed)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 6. |
- Petrache, C. M., et al.
(author)
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Multiple triaxial bands in Nd-138
- 2015
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In: Physical Review C (Nuclear Physics). - 0556-2813. ; 91:2
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Journal article (peer-reviewed)abstract
- High-spin states in Nd-138 were investigated by using the Ca-48 + Zr-94 reaction and gamma-ray coincidences were acquired with the GASP spectrometer. A rich level scheme was developed including 14 new bands of quadrupole transitions at very high spins. Linking transitions connecting 11 high-spin bands to low-energy states have been observed. Calculations based on the cranked Nilsson-Strutinsky formalism have been used to assign configurations to the observed bands. The main result of these calculations is that all 14 bands exhibit a stable triaxial deformation up to the highest observed spins, giving strong support to the existence of a triaxial minimum with normal deformation and positive asymmetry parameter in nuclei with a few holes in the N = 82 shell closure.
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| 7. |
- Petrache, C. M., et al.
(author)
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Switch from short-axis to intermediate-axis rotation in Nd-138
- 2013
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In: Physical Review C (Nuclear Physics). - 0556-2813. ; 88:5
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Journal article (peer-reviewed)abstract
- It is pointed out that the triaxial bands in Nd138-140 and in the Lu/Er nuclei can be understood from the same shell structure effects. Two of the bands in Nd-138, interpreted as signature partners, exhibit a crossing at high spins with a signature splitting which is strongly reduced above the crossing. This behavior is unique among the yrast and close-to-yrast configurations, revealing the mechanism which induces a change of the rotation axis from short to intermediate in the triaxially deformed nucleus.
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| 8. |
- Xu, Hai-Sen, et al.
(author)
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Single crystal of a one-dimensional metallo-covalent organic framework
- 2020
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- Although polymers have been studied for well over a century, there are few examples of covalently linked polymer crystals synthesised directly from solution. One-dimensional (1D) covalent polymers that are packed into a framework structure can be viewed as a 1D covalent organic framework (COF), but making a single crystal of this has been elusive. Herein, by combining labile metal coordination and dynamic covalent chemistry, we discover a strategy to synthesise single-crystal metallo-COFs under solvothermal conditions. The single-crystal structure is rigorously solved using single-crystal electron diffraction technique. The non-centrosymmetric metallo-COF allows second harmonic generation. Due to the presence of syntactic pendant amine groups along the polymer chains, the metallopolymer crystal can be further cross-linked into a crystalline woven network. Although polymers have been studied for well over a century, there are few examples of covalently linked polymer crystals synthesized directly from solution. Here, the authors demonstrate a strategy to synthesize single crystalline 1D metallo-covalent organic frameworks by combining dynamic covalent chemistry and metal-ligand coordination.
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