| 1. |
- Małyszko, Jolanta, et al.
(author)
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Do we know more about hypertension in Poland after the May Measurement Month 2017? - Europe
- 2019
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In: European Heart Journal, Supplement. - : Oxford University Press (OUP). - 1520-765X .- 1554-2815. ; 21, s. 97-100
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Research review (peer-reviewed)abstract
- Elevated blood pressure (BP) is a worldwide burden, leading to over 10 million deaths yearly. May Measurement Month (MMM) is a global initiative organized by the International Society of Hypertension aimed at raising awareness of hypertension and the need for BP screening. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May 2017. BP measurement, the definition of hypertension and statistical analysis followed the globally approved MMM17 Study Protocol. In Poland 5834 (98.9%, Caucasian) individuals were screened. After multiple imputation, 2601 (35.3%) had hypertension. Of individuals not receiving anti-hypertensive medication, 976 (20.6%) were hypertensive. Of individuals receiving anti-hypertensive medication, 532 (49.1%) had uncontrolled BP. In the crude screened group, 81.4% declared to not receive any anti-hypertensive treatment, while the remaining 18.6% were on such medications. In overweight and obese patients both systolic and diastolic BP were significantly higher than in normal weight and underweight subjects. In addition, BP measured on Sundays was significantly lower than on Mondays. MMM17 was one of the largest recent BP screening campaigns in Poland. We found that over 1/3 of participants were hypertensive. Almost half of the treated subjects had uncontrolled BP. These results suggest that opportunistic screening can identify substantial numbers with raised BP.
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| 2. |
- Gustafson, Johan, et al.
(author)
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The Role of Oxides in Catalytic CO Oxidation over Rhodium and Palladium
- 2018
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In: ACS Catalysis. - : American Chemical Society (ACS). - 2155-5435. ; 8:5, s. 4438-4445
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Journal article (peer-reviewed)abstract
- Catalytic CO oxidation is a seemingly simple reaction between CO and O2 molecules, one of the reactions in automotive catalytic converters, and the fruit-fly reaction in model catalysis. Surprisingly, the phase responsible for the catalytic activity is still under debate, despite decades of investigations. We have performed a simple but yet conclusive study of single crystal Rh and Pd model catalysts, resolving this controversy. For Rh, the oxygen-covered metallic surface is more active than the oxide, while for Pd, thin oxidefilms are at least as active as the metallic surface, but a thicker oxide is less active. Apart from resolving a long-standing debate, our results pinpoint important design principles for oxidation catalysts as to prevent catalytic extinction at high oxygen exposures.
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| 3. |
- Jankowski, Piotr, 1990, et al.
(author)
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Understanding of Lithium 4,5-Dicyanoimidazolate-Poly(ethylene oxide) System: Influence of the Architecture of the Solid Phase on the Conductivity
- 2016
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In: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 120:41, s. 23358-23367
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Journal article (peer-reviewed)abstract
- Solid polymer electrolytes (SPEs) with high lithium conductivity are very beneficial as a safe material for lithium battery applications. Herein we present new set of a SPEs based on lithium 2-trifluoromethyl-4,5-dicyanoimidazolate (LiTDI) with wide range of ether oxygen to lithium molar ratios. The phase composition was characterized in detail with thermal, diffraction, and spectroscopic techniques, and its influence on conductivity behavior was examined. Two detected crystalline phases of LiTDI poly(ethylene oxide) (PEO) were simulated with computational methods. The obtained results allowed insight into the structure of these electrolytes and helped us to understand on the molecular level factors influencing electrochemical properties and phase behavior. It was shown that ability to form a low-melting phase can be used to lower the temperature window of operation. That made it possible to keep such SPEs amorphous at 30 degrees C during 80 days. The thermal stability of the samples was checked to prove the safety of the electrolytes.
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| 4. |
- Pétri, Jérôme A., et al.
(author)
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Constraining the magnetic field geometry of the millisecond pulsar PSRJ0030+0451 from joint radio, thermal X-ray, and γ-ray emission
- 2023
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In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 680
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Journal article (peer-reviewed)abstract
- Context. With the advent of multi-wavelength electromagnetic observations of neutron stars - spanning many decades in photon energies - from radio wavelengths up to X-rays and γ-rays, it has become possible to significantly constrain the geometry and the location of the associated emission regions. Aims. In this work, we use results from the modelling of thermal X-ray observations of PSR J0030+0451 from the Neutron Star Interior Composition Explorer (NICER) mission and phase-aligned radio and γ-ray pulse profiles to constrain the geometry of an off-centred dipole that is able to reproduce the light curves in these respective bands simultaneously. Methods. To this aim, we deduced a configuration with a simple dipole off-centred from the location of the centre of the thermal X-ray hot spots. We show that the geometry is compatible with independent constraints from radio and -ray pulsations only, leading to a fixed magnetic obliquity of α ≈ 75° and a line-of-sight inclination angle of ζ ≈ 54°. Results. We demonstrate that an off-centred dipole cannot be rejected by accounting for the thermal X-ray pulse profiles. Moreover, the crescent shape of one spot is interpreted as the consequence of a small-scale surface dipole on top of the large-scale off-centred dipole.
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| 5. |
- Piotrowski, Arkadiusz, et al.
(author)
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Somatic mosaicism for copy number variation in differentiated human tissues
- 2008
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In: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 29:9, s. 1118-24
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Journal article (peer-reviewed)abstract
- Two major types of genetic variation are known: single nucleotide polymorphisms (SNPs), and a more recently discovered structural variation, involving changes in copy number (CNVs) of kilobase- to megabase-sized chromosomal segments. It is unknown whether CNVs arise in somatic cells, but it is, however, generally assumed that normal cells are genetically identical. We tested 34 tissue samples from three subjects and, having analyzed for each tissue < or =10(-6) of all cells expected in an adult human, we observed at least six CNVs, affecting a single organ or one or more tissues of the same subject. The CNVs ranged from 82 to 176 kb, often encompassing known genes, potentially affecting gene function. Our results indicate that humans are commonly affected by somatic mosaicism for stochastic CNVs, which occur in a substantial fraction of cells. The majority of described CNVs were previously shown to be polymorphic between unrelated subjects, suggesting that some CNVs previously reported as germline might represent somatic events, since in most studies of this kind, only one tissue is typically examined and analysis of parents for the studied subjects is not routinely performed. A considerable number of human phenotypes are a consequence of a somatic process. Thus, our conclusions will be important for the delineation of genetic factors behind these phenotypes. Consequently, biobanks should consider sampling multiple tissues to better address mosaicism in the studies of somatic disorders.
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| 6. |
- Ronowicz, Anna, et al.
(author)
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Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients
- 2015
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In: Human Mutation. - : Hindawi Limited. - 1059-7794 .- 1098-1004. ; 36:11, s. 1088-1099
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Journal article (peer-reviewed)abstract
- Somatic mosaicism for DNA copy-number alterations (SMC-CNAs) is defined as gain or loss of chromosomal segments in somatic cells within a single organism. As cells harboring SMC-CNAs can undergo clonal expansion, it has been proposed that SMC-CNAs may contribute to the predisposition of these cells to genetic disease including cancer. Herein, the gross genomic alterations (>500 kbp) were characterized in uninvolved mammary glandular tissue from 59 breast cancer patients and matched samples of primary tumors and lymph node metastases. Array-based comparative genomic hybridization showed 10% (6/59) of patients harbored one to 359 large SMC-CNAs (mean: 1,328 kbp; median: 961 kbp) in a substantial portion of glandular tissue cells, distal from the primary tumor site. SMC-CNAs were partially recurrent in tumors, albeit with considerable contribution of stochastic SMC-CNAs indicating genomic destabilization. Targeted resequencing of 301 known predisposition and somatic driver loci revealed mutations and rare variants in genes related to maintenance of genomic integrity: BRCA1 (p.Gln1756Profs*74, p.Arg504Cys), BRCA2 (p.Asn3124Ile), NCOR1 (p.Pro1570Glnfs*45), PALB2 (p.Ser500Pro), and TP53 (p.Arg306*). Co-occurrence of gross SMC-CNAs along with point mutations or rare variants in genes responsible for safeguarding genomic integrity highlights the temporal and spatial neoplastic potential of uninvolved glandular tissue in breast cancer patients.
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