| 1. |
- Bombarda, F., et al.
(author)
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Runaway electron beam control
- 2019
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Journal article (peer-reviewed)
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| 2. |
- Kim, Angela, et al.
(author)
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Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.
- 2021
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In: eLife. - 2050-084X. ; 10
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Journal article (peer-reviewed)abstract
- Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon. Varying glucose over the range of concentrations that occur physiologically between the fed and fuel-deprived states (8 to 4 mM) has no significant effect on glucagon secretion in the perfused mouse pancreas or in isolated mouse islets (in vitro), and yet associates with dramatic increases in plasma glucagon. The identity of the systemic factor(s) that elevates circulating glucagon remains unknown. Here, we show that arginine-vasopressin (AVP), secreted from the posterior pituitary, stimulates glucagon secretion. Alpha-cells express high levels of the vasopressin 1b receptor (V1bR) gene (Avpr1b). Activation of AVP neurons in vivo increased circulating copeptin (the C-terminal segment of the AVP precursor peptide) and increased blood glucose; effects blocked by pharmacological antagonism of either the glucagon receptor or V1bR. AVP also mediates the stimulatory effects of hypoglycemia produced by exogenous insulin and 2-deoxy-D-glucose on glucagon secretion. We show that the A1/C1 neurons of the medulla oblongata drive AVP neuron activation in response to insulin-induced hypoglycemia. AVP injection increased cytoplasmic Ca2+ in alpha-cells (implanted into the anterior chamber of the eye) and glucagon release. Hypoglycemia also increases circulating levels of AVP/copeptin in humans and this hormone stimulates glucagon secretion from human islets. In patients with T1D, hypoglycemia failed to increase both copeptin and glucagon. These findings suggest that AVP is a physiological systemic regulator of glucagon secretion and that this mechanism becomes impaired in T1D.
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| 3. |
- Meyer, H., et al.
(author)
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Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
- 2017
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In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:10
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Journal article (peer-reviewed)abstract
- Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement H-H(98,H-y2) approximate to 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.
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| 4. |
- Meyer, H., et al.
(author)
-
Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
- 2017
-
In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:10
-
Journal article (peer-reviewed)abstract
- Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement H-H(98,H-y2) approximate to 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.
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| 5. |
- Orlando, Ludovic, et al.
(author)
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Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse
- 2013
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 499:7456, s. 74-
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Journal article (peer-reviewed)abstract
- The rich fossil record of equids has made them a model for evolutionary processes(1). Here we present a 1.12-times coverage draft genome from a horse bone recovered from permafrost dated to approximately 560-780 thousand years before present (kyr BP)(2,3). Our data represent the oldest full genome sequence determined so far by almost an order of magnitude. For comparison, we sequenced the genome of a Late Pleistocene horse (43 kyr BP), and modern genomes of five domestic horse breeds (Equus ferus caballus), a Przewalski's horse (E. f. prze-walskii) and a donkey (E. asinus). Our analyses suggest that the Equus lineage giving rise to all contemporary horses, zebras and donkeys originated 4.0-4.5 million years before present (Myr BP), twice the conventionally accepted time to the most recent common ancestor of the genus Equus(4,5). We also find that horse population size fluctuated multiple times over the past 2 Myr, particularly during periods of severe climatic changes. We estimate that the Przewalski's and domestic horse populations diverged 38-72 kyr BP, and find no evidence of recent admixture between the domestic horse breeds and the Przewalski's horse investigated. This supports the contention that Przewalski's horses represent the last surviving wild horse population(6). We find similar levels of genetic variation among Przewalski's and domestic populations, indicating that the former are genetically viable and worthy of conservation efforts. We also find evidence for continuous selection on the immune system and olfaction throughout horse evolution. Finally, we identify 29 genomic regions among horse breeds that deviate from neutrality and show low levels of genetic variation compared to the Przewalski's horse. Such regions could correspond to loci selected early during domestication.
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| 6. |
- Sorensen, Jarle Lowe, et al.
(author)
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Old dogs, new tricks? A Norwegian study on whether previous collaboration exercise experience impacted participant’s perceived exercise effect
- 2019
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In: International Journal of Emergency Services. - 2047-0894 .- 2047-0908. ; 8:2, s. 122-133
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Journal article (peer-reviewed)abstract
- Purpose: The purpose of this paper is to investigate the perceived effects of a maritime cross-sector collaboration exercise. More specifically, this study aims to examine whether past exercise experience had an impact on the operative exercise participant’s perceived levels of collaboration, learning and usefulness. Design/methodology/approach: This was a non-experimental quantitative survey-based study. A quantitative methodology was chosen over qualitative or mixed-methods methodologies as it was considered more suitable for data extraction from larger population groups, and allowed for the measurement and testing of variables using statistical methods and procedures (McCusker and Gunaydin, 2015). Data were collected from a two-day 2017 Norwegian full-scale maritime chemical oil-spill pollution exercise with partners from Norway, Germany, Iceland, Denmark and Sweden. The exercise included international public emergency response organizations and Norwegian non-governmental organizations. The study was approved by the Norwegian Centre for Research Data (ref. 44815) and the exercise planning organization. Data were collected using the collaboration, learning and utility (CLU) scale, which is a validated instrument designed to measure exercise participant’s perceived levels of collaboration, learning and usefulness (Berlin and Carlström, 2015). Findings: The perceived focus on collaboration, learning and usefulness changed with the number of previous exercises attended. All CLU dimensions experienced decreases and increases, but while perceived levels of collaboration and utility reached their somewhat modest peaks among those with the most exercise experience, perceived learning was at its highest among those with none or little exercise experience, and at its lowest among those with most. These findings indicated that collaboration exercises in their current form have too little focus on collaborative learning. Research limitations/implications: Several limitations of the current study deserve to be mentioned. First, this study was limited in scope as data were collected from a limited number of participants belonging to only one organization and during one exercise. Second, demographical variables such as age and gender were not taken into consideration. Third, limitation in performing a face-to-face data collection may have resulted in missing capturing of cues, verbal and non-verbal signs, which could have resulted in a more accurate screening. Moreover, the measurements were based on the predefined CLU-items, which left room for individual interpretation and, in turn, may cause somewhat lower term validity. As the number of international and national studies on exercise effects is scarce, it is important to increase further knowledge and to learn more about the causes as to why the perceived effects of collaboration exercises are considered somewhat limited. Practical implications: Exercise designers may be stimulated to have a stronger emphasis on collaborative learning during exercise planning, hence continuously work to develop scripts and scenarios in a way that leads to continuous participant perceived learning and utility. Social implications: Collaboration is established as a Norwegian national emergency preparedness principle. These findings may stimulate politicians and top crisis managers to develop national collaboration exercise script guidelines that emphasize collaborative learning and development. Originality/value: This study shows how exercise experience impacted participant’s perceived levels of collaboration, learning and usefulness. Findings indicated that collaboration exercises in their current form have too little focus on collaborative learning.
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| 7. |
- Sorensen, J. L., et al.
(author)
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The Organizer Dilemma: Outcomes from a Collaboration Exercise
- 2019
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In: International Journal of Disaster Risk Science. - : Springer Science and Business Media LLC. - 2095-0055 .- 2192-6395. ; 10:2, s. 261-269
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Journal article (peer-reviewed)abstract
- In crisis management, cross-sector collaboration exercises are perceived as improving preparedness and develop team-integration efforts. However, studies show that exercises may tend to produce results with limited learning and usefulness. The purpose of this nonexperimental, survey-based study was to measure the difference in perceived exercise effect between participants belonging to the exercise planning organizations and participants belonging to other participating groups. Surveys were distributed and collected from participants in a 2017 chemical oil-spill exercise set off the southern coast of Norway. The target population was operational staff, excluding exercise management and directing staff. The sample population consisted of operatives associated with the exercise organizer organization and others belonging to external public and nongovernmental emergency organizations. The data collection instrument was the Collaboration, Learning, and Utility Scale (CLU-scale). Findings indicated that the levels of CLU were higher among external participants than among those individuals who belong to the exercise planning organizations. This study recommends the development and adoption of a national maritime collaboration exercise framework. A practical implication is a recommendation to evaluate exercises to secure the outcome regarding collaboration skill using the same instrument.
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| 8. |
-
- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:9
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Journal article (peer-reviewed)
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| 9. |
-
- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Research review (peer-reviewed)
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