| 1. |
- Beziat, Vivien, et al.
(author)
-
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
- 2013
-
In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 121:14, s. 2678-2688
-
Journal article (peer-reviewed)abstract
- Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is genetically hard-wired, we hypothesized that KIR repertoire perturbations reflect expansions of unique NK-cell subsets and may be used to trace adaptation of the NK-cell compartment to virus infections. By determining the human KIR-ome at a single-cell level in more than 200 donors, we were able to analyze the magnitude of NK cell adaptation to virus infections in healthy individuals. Strikingly, infection with human cytomegalovirus (CMV), but not with other common herpesviruses, induced expansion and differentiation of KIR-expressing NK cells, visible as stable imprints in the repertoire. Education by inhibitory KIRs promoted the clonal-like expansion of NK cells, causing a bias for self-specific inhibitory KIRs. Furthermore, our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2, or KIR3DS1), in addition to NKG2C, in the expansion of human NK cells. These results provide new insight into the diversity of KIR repertoire and its adaptation to virus infection, suggesting a role for both activating and inhibitory KIRs in immunity to CMV infection.
|
|
| 2. |
|
|
| 3. |
- Språngberg, A, et al.
(author)
-
SBU. Godartad prostataförstoring med avflödeshinder. En systematisk litteraturöversikt : Godartad prostataförstoring med avflödeshinder
- 2011
-
Reports (other academic/artistic)abstract
- Slutsatser Godartad prostataförstoring (benign prostatahyperplasi, BPH) är ett vanligt tillstånd som med stigande ålder drabbar i princip alla män. En del av dessa män får urineringsproblem och cirka 4 500 opereras varje år för en förstorad prostata. Många med lindrigare besvär behandlas med läkemedel eller behöver ingen behandling alls. Avflödeshinder kan obehandlat ge allvarlig urinretention som skadar njurarna, och en urinstämma kan vara livshotande. För att avgränsa den grupp av män där problemen med urineringen beror på en förstorad prostata används ett tiotal olika diagnostiska metoder. När det gäller behandling finns det flera olika kirurgiska metoder, varav några är väl etablerade och andra av mer experimentell karaktär. Under 1990-talet har också flera läkemedel introducerats. SBU har därför bedömt att det funnits ett behov av att göra en systematisk genomgång av den vetenskapliga grunden för dessa olika metoder. Nedan följer de viktigaste slutsatserna av arbetet.
|
|
| 4. |
- Brunsell, Per, et al.
(author)
-
Initial results from the rebuilt EXTRAP T2R RFP device
- 2001
-
In: Plasma Physics and Controlled Fusion. - BRISTOL. ENGLAND : IOP PUBLISHING LTD. - 0741-3335 .- 1361-6587. ; 43:11, s. 1457-1470
-
Journal article (peer-reviewed)abstract
- The EXTRAP T2R thin shell reversed-field pinch (RFP) device has recently resumed operation after a major rebuild including the replacement of the graphite armour with molybdenum limiters, a fourfold increase of the shell time constant, and the replacement of the helical coil used for the toroidal field with a conventional solenoid-type coil. Wall-conditioning using hydrogen glow discharge cleaning was instrumental for successful RFP operation. Carbon was permanently removed from the walls during the first week of operation. The initial results from RFP operation with relatively low plasma currents in the range I-p = 70-100 kA are reported. RFP discharges are sustained for more than three shell times. Significant improvements in plasma parameters are observed, compared to operation before the rebuild. There is a substantial reduction in the carbon impurity level. The electron density behaviour is more shot-to-shot reproducible. The typical density is n(e) = 0.5-1 x 10(19) m(-3). Monitors of H-alpha line radiation indicate that the plasma wall interaction is more toroidally symmetric and that there is less transient gas release from the wall. The minimum loop voltage is in the range V-t = 28-35 V, corresponding to a reduction by a factor of two to three compared to the value before the rebuild.
|
|
| 5. |
|
|
| 6. |
- Cecconello, Marco, et al.
(author)
-
Current profile modification experiments in EXTRAP T2R
- 2004
-
In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 46:1, s. 145-161
-
Journal article (peer-reviewed)abstract
- Pulsed poloidal current drive (PPCD) experiments have been conducted in the resistive shell EXTRAP T2R reversed-field pinch experiment. During the current profile modification phase, the fluctuation level of the m = 1 internally resonant tearing modes decreases, and the velocity of these modes increases. The m = 0 modes are not affected during PPCD, although termination occurs with a burst in the m = 0 amplitude. The PPCD phase is characterized by an increase in the central electron temperature (up to 380 eV) and in the soft x-ray signal. Spectroscopic observations confirm an increase in the central electron temperature. During PPCD, the plasma poloidal beta increases to 14%, and the estimated energy confinement time doubles, reaching 380 mus. The reduction in the fluctuation level and the corresponding increase in the energy confinement time are qualitatively consistent with a reduction in parallel transport along stochastic magnetic field lines.
|
|
| 7. |
- Drake, James R., et al.
(author)
-
Experimental studies of MHD dynamics in a RFP magnetically confined plasma
- 2004
-
In: Contributions to Plasma Physics. - : Wiley. - 0863-1042 .- 1521-3986. ; 44:06-maj, s. 503-507
-
Journal article (peer-reviewed)abstract
- Studies of non-linear dynamics of MHD tearing modes in the EXTRAP reversed-field pinch experiments [1] have demonstrated such phenomena as mode rotation, phase-locking and wall locking.
|
|
| 8. |
- Malmberg, Jenny A., et al.
(author)
-
Mode- and plasma rotation in a resistive shell reversed-field pinch
- 2004
-
In: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 11:2, s. 647-658
-
Journal article (peer-reviewed)abstract
- Mode rotation studies in a resistive shell reversed-field pinch, EXTRAP T2R [P. R. Brunsell , Plasma Phys. Control. Fusion 43, 1 (2001)] are presented. The phase relations and nonlinear coupling of the resonant modes are characterized and compared with that expected from modeling based on the hypothesis that mode dynamics can be described by a quasi stationary force balance including electromagnetic and viscous forces. Both m=0 and m=1 resonant modes are studied. The m=1 modes have rotation velocities corresponding to the plasma flow velocity (20-60 km/s) in the core region. The rotation velocity decreases towards the end of the discharge, although the plasma flow velocity does not decrease. A rotating phase locked m=1 structure is observed with a velocity of about 60 km/s. The m=0 modes accelerate throughout the discharges and reach velocities as high as 150-250 km/s. The observed m=0 phase locking is consistent with theory for certain conditions, but there are several conditions when the dynamics are not described. This is not unexpected because the assumption of quasi stationarity for the mode spectra is not fulfilled for many conditions. Localized m=0 perturbations are formed in correlation with highly transient discrete dynamo events. These perturbations form at the location of the m=1 phase locked structure, but rotate with a different velocity as they spread out in the toroidal direction. (C) 2004 American Institute of Physics.
|
|
