SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Malmberg P.) "

Search: WFRF:(Malmberg P.)

  • Result 1-10 of 163
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  • Broadaway, K Alaine, et al. (author)
  • Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
  • 2023
  • In: American Journal of Human Genetics. - : Elsevier. - 0002-9297 .- 1537-6605. ; 110:2, s. 284-299
  • Journal article (peer-reviewed)abstract
    • Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. We conducted meta-analyses of genome-wide association results for fasting proinsulin from 16 European-ancestry studies in 45,861 individuals. We found 36 independent signals at 30 loci (p value < 5 × 10-8), which validated 12 previously reported loci for proinsulin and ten additional loci previously identified for another glycemic trait. Half of the alleles associated with higher proinsulin showed higher rather than lower effects on glucose levels, corresponding to different mechanisms. Proinsulin loci included genes that affect prohormone convertases, beta-cell dysfunction, vesicle trafficking, beta-cell transcriptional regulation, and lysosomes/autophagy processes. We colocalized 11 proinsulin signals with islet expression quantitative trait locus (eQTL) data, suggesting candidate genes, including ARSG, WIPI1, SLC7A14, and SIX3. The NKX6-3/ANK1 proinsulin signal colocalized with a T2D signal and an adipose ANK1 eQTL signal but not the islet NKX6-3 eQTL. Signals were enriched for islet enhancers, and we showed a plausible islet regulatory mechanism for the lead signal in the MADD locus. These results show how detailed genetic studies of an intermediate phenotype can elucidate mechanisms that may predispose one to disease.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  • Cecconello, Marco, et al. (author)
  • Current profile modification experiments in EXTRAP T2R
  • 2004
  • In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 46:1, s. 145-161
  • Journal article (peer-reviewed)abstract
    • Pulsed poloidal current drive (PPCD) experiments have been conducted in the resistive shell EXTRAP T2R reversed-field pinch experiment. During the current profile modification phase, the fluctuation level of the m = 1 internally resonant tearing modes decreases, and the velocity of these modes increases. The m = 0 modes are not affected during PPCD, although termination occurs with a burst in the m = 0 amplitude. The PPCD phase is characterized by an increase in the central electron temperature (up to 380 eV) and in the soft x-ray signal. Spectroscopic observations confirm an increase in the central electron temperature. During PPCD, the plasma poloidal beta increases to 14%, and the estimated energy confinement time doubles, reaching 380 mus. The reduction in the fluctuation level and the corresponding increase in the energy confinement time are qualitatively consistent with a reduction in parallel transport along stochastic magnetic field lines.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 163
Type of publication
journal article (122)
conference paper (30)
research review (4)
reports (3)
other publication (2)
doctoral thesis (2)
show more...
show less...
Type of content
peer-reviewed (132)
other academic/artistic (31)
Author/Editor
Malmberg, P (37)
Malmberg, KJ (25)
Malmberg, K (17)
Larsson, K (13)
Ljunggren, HG (11)
Rydén, L. (10)
show more...
Palmberg, L (10)
Ljungman, P (8)
Renstrom, A (8)
Malmberg, A (7)
Almqvist, C (6)
Martin, P. (6)
Sundell, J (6)
Spizzo, G. (6)
Premji, Zul (5)
Davies, Melvyn B (5)
Malmberg, Per, 1974 (5)
Dickstein, K (5)
Lindgren, P (5)
Önfelt, Björn (5)
Bjorkstrom, NK (5)
Franz, P. (5)
Marrelli, L. (5)
Miller, JS (5)
Hedrén, M (5)
Gordon, S (4)
Allebeck, P (4)
Efendic, S (4)
Jonsson, B (4)
Mårtensson, Andreas (4)
Drake, James Robert (4)
Cecconello, M (4)
Piovesan, P (4)
Cecconello, Marco (4)
Larsson, P (4)
Björkman, Anders (4)
Watz, E. (4)
Heederik, D (4)
Wickman, M (4)
Lahti, J (4)
Snieder, H. (4)
Laakso, M. (4)
Schaffer, M (4)
Ngasala, Billy (4)
Malmberg, Filip (4)
Norhammar, A. (4)
Höglund, P. (4)
Lewis, G. (4)
Carlsten, M (4)
Hellstrom-Lindberg, ... (4)
show less...
University
Karolinska Institutet (104)
Royal Institute of Technology (23)
Uppsala University (21)
Lund University (18)
University of Gothenburg (7)
Swedish University of Agricultural Sciences (7)
show more...
Linköping University (6)
Chalmers University of Technology (6)
Umeå University (4)
RISE (4)
University of Borås (3)
Jönköping University (2)
Karlstad University (2)
Högskolan Dalarna (2)
Mid Sweden University (1)
Red Cross University College (1)
show less...
Language
English (160)
Swedish (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (36)
Natural sciences (28)
Engineering and Technology (7)
Social Sciences (2)
Agricultural Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view