| 1. |
- Carraminana, Albert, et al.
(author)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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In: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Journal article (peer-reviewed)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 2. |
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| 3. |
- Hudson, Lawrence N, et al.
(author)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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In: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Journal article (peer-reviewed)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 4. |
- Carretero Cerdan, Alba, et al.
(author)
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Enhancing the chirality transfer in the Isomeri-zation of Electron-deficient Allylic Alcohols.
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Other publication (other academic/artistic)abstract
- The study of a confined space for the isomerization of electron-deficient allylic alcohols have been studied. The materials choosen for this purpose are porous materials from commercial avilable polymers to Metal-Organic Frameworks. A derivative of UiO-67 MOF type have been choosen due to its chemical and thermodynamic stability. The heterogeneous material synthesized is robust and it has sligthly improved the chirality transfer in the isomerization of certain allylic alcohols.
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| 5. |
- García-Vázquez, Víctor, et al.
(author)
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Synthesis of α,γ-Chiral Trifluoromethylated Amines through the Stereospecific Isomerization of α-Chiral Allylic Amines
- 2022
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In: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 24:21, s. 3867-3871
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Journal article (peer-reviewed)abstract
- Chiral γ-branched aliphatic amines are present in a large number of pharmaceuticals and natural products. However, enantioselective methods to access these compounds are scarce and mainly rely on the use of designed chiral transition-metal complexes. Herein, we combined an organocatalytic method for the stereospecific isomerization of chiral allylic amines with a diastereoselective reduction of the chiral imine/enamine intermediates, leading to γ-trifluoromethylated aliphatic amines with two noncontiguous stereogenic centers, in excellent yields and high diastereo- and enantioselectivities. This approach has been used with primary amine substrates. This approach also provides a new synthetic pathway to chiral trifluoromethylated scaffolds, of importance in medicinal chemistry. Additionally, a gram-scale reaction demonstrates the applicability of this synthetic procedure.
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| 6. |
- Hudson, Lawrence N., et al.
(author)
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The PREDICTS database : a global database of how local terrestrial biodiversity responds to human impacts
- 2014
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In: Ecology and Evolution. - : Wiley. - 2045-7758. ; 4:24, s. 4701-4735
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Journal article (peer-reviewed)abstract
- Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - ). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
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| 7. |
- Postole, Alexandru, et al.
(author)
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Chiral trifluoromethylated enamides : Synthesis and applications
- 2023
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In: Chem catalysis. - 2667-1093. ; 3:12
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Journal article (peer-reviewed)abstract
- Enamides are versatile building blocks in organic synthesis that give ac-cess to complex nitrogen-containing compounds. However, despite the interest in these compounds, synthetic strategies to access enam-ides with carbon-centered chirality are scarce. In this work, we report an efficient method for the synthesis of a new class of chiral enamides with a trifluoromethylated stereogenic center from easily accessible chiral allylic amines by an effective chirality-transfer process. The method gives excellent yields and diastereo-and enantioselectivities. The scope of the reaction is broad, and various substituents and func-tional groups are tolerated. Furthermore, various organic transforma-tions were carried out to access new trifluoromethylated, complex chi-ral structures. For example, a new photocatalytic method for the E/Z isomerization of enamides is also presented.
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| 8. |
- Valiente, Alejandro, 1992-, et al.
(author)
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Electrochemical Generation of Hydrides over a Nickel Foam for Z-Stereoselective Semihydrogenation/deuteration of Functionalized Alkynes
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Other publication (other academic/artistic)abstract
- Selective reduction strategies based on abundant-metal catalysts are very important in the production of chemicals. In this paper, we present a method for the electrochemical semihydrogenation and semideuteration of alkynes to form Z-alkenes using a simplenickel foam as catalyst and H3O+or D3O+as sources of hydrogen or deuterium. Good yields and excellent stereoselectivities (Z/E up to 20:1) are obtained under very mild reaction conditions. The reaction works with terminal and nonterminal alkynes, and with alkynes containing easily reducible functional groups, such as carbonyl groups, and aryl chlorides, bromides, and even iodides. The nickel-foam electrocatalyst can be recycled up to 14 times without any change in its catalytic properties.
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| 9. |
- Valiente, Alejandro, et al.
(author)
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Electrochemical Proton Reduction over Nickel Foam for Z-Stereoselective Semihydrogenation/deuteration of Functionalized Alkynes
- 2022
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In: ChemSusChem. - : Wiley. - 1864-5631 .- 1864-564X. ; 15:1
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Journal article (peer-reviewed)abstract
- Selective reduction strategies based on abundant-metal catalysts are very important in the production of chemicals. In this paper, a method for the electrochemical semihydrogenation and semideuteration of alkynes to form Z-alkenes was developed, using a simple nickel foam as catalyst and H3O+ or D3O+ as sources of hydrogen or deuterium. Good yields and excellent stereoselectivities (Z/E up to 20 : 1) were obtained under very mild reaction conditions. The reaction proceeded with terminal and nonterminal alkynes, and also with alkynes containing easily reducible functional groups, such as carbonyl groups, as well as aryl chlorides, bromides, and even iodides. The nickel-foam electrocatalyst could be recycled up to 14 times without any change in its catalytic properties.
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