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Träfflista för sökning "WFRF:(Marthanda Pratheek Bellur) "

Sökning: WFRF:(Marthanda Pratheek Bellur)

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  • Lilja, Sandra, et al. (författare)
  • Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases
  • 2023
  • Ingår i: Cell Reports Medicine. - : ELSEVIER. - 2666-3791. ; 4:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Prioritization of disease mechanisms, biomarkers, and drug targets in immune-mediated inflammatory dis-eases (IMIDs) is complicated by altered interactions between thousands of genes. Our multi-organ single -cell RNA sequencing of a mouse IMID model, namely collagen-induced arthritis, shows highly complex and heterogeneous expression changes in all analyzed organs, even though only joints showed signs of inflammation. We organized those into a multi-organ multicellular disease model, which shows predicted mo-lecular interactions within and between organs. That model supports that inflammation is switched on or off by altered balance between pro-and anti-inflammatory upstream regulators (URs) and downstream path-ways. Meta-analyses of human IMIDs show a similar, but graded, on/off switch system. This system has the potential to prioritize, diagnose, and treat optimal combinations of URs on the levels of IMIDs, subgroups, and individual patients. That potential is supported by UR analyses in more than 600 sera from patients with systemic lupus erythematosus.
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