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1.	Jakobsson, J., et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Journal article (peer-reviewed)
2.	Betancor, M., et al. (author) Neurogranin and Neurofilament Light Chain as Preclinical Biomarkers in Scrapie 2022 In: International Journal of Molecular Sciences. - : MDPI AG. - 1422-0067. ; 23:13 Journal article (peer-reviewed)abstract Prion diseases are diagnosed in the symptomatic stage, when the neuronal damage is spread throughout the central nervous system (CNS). The assessment of biological features that allow the detection of asymptomatic cases is needed, and, in this context, scrapie, where pre-symptomatic infected animals can be detected through rectal biopsy, becomes a good study model. Neurogranin (Ng) and neurofilament light chain (NfL) are proteins that reflect synaptic and axonal damage and have been studied as cerebrospinal fluid (CSF) biomarkers in different neurodegenerative disorders. In this study, we evaluated Ng and NfL both at the protein and transcript levels in the CNS of preclinical and clinical scrapie-affected sheep compared with healthy controls and assessed their levels in ovine CSF. The correlation between these proteins and the main neuropathological events in prion diseases, PrPSc deposition and spongiosis, was also assessed. The results show a decrease in Ng and NfL at the protein and gene expression levels as the disease progresses, and significant changes between the control and preclinical animals. On the contrary, the CSF levels of NfL increased throughout the progression of the disease. Negative correlations between neuropathological markers of prion disease and the concentration of the studied proteins were also found. Although further research is needed, these results suggest that Ng and NfL could act as biomarkers for neurodegeneration onset and intensity in preclinical cases of scrapie.
3.	Karlsen, T. H., et al. (author) The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality 2022 In: The Lancet. - 0140-6736. ; 399:10319, s. 61-116 Journal article (peer-reviewed)

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Liu, X (1); Chen, L (1); Alonso, A. (1); Chen, S. (1); Chen, X. (1); Chen, Y. (1); show more...; Donadelli, M. (1); Gupta, S. (1); Hu, D. (1); Jiang, Y. (1); Jin, S. (1); Kim, H. (1); Kono, T. (1); Li, B. (1); Li, S. (1); Li, Y. (1); Liu, Y. (1); Meyer, C. (1); Mohapatra, S. (1); Nakamura, K. (1); Nilsson, P. (1); Shimizu, S. (1); Takahashi, Y. (1); Wang, C. (1); Wang, F. (1); Wang, H. (1); Wang, J. (1); Wang, K. (1); Wu, M. (1); Xu, L. (1); Yamamoto, A. (1); Yan, Z. (1); Yang, H. (1); Yang, Y. (1); Yu, J. (1); Zhang, H. (1); Zhang, L. (1); Zhang, X. (1); Zhang, Z. (1); Zhou, B. (1); Zhu, H. (1); Liu, J. (1); Zhao, Y. (1); Belloni, A. (1); Lange, C. (1); Li, X. (1); Zhao, L. (1); Liu, C. (1); Liu, H. (1); Saito, T (1); show less...

University: University of Gothenburg (2); Umeå University (1); Stockholm University (1); Linköping University (1); Lund University (1); Karolinska Institutet (1); show more...; Swedish University of Agricultural Sciences (1); show less...

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (2); Medical and Health Sciences (2)

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