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- Urooj, Faiza, et al.
(author)
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Socio-demographic characteristics of children and young people with primary brain tumours : comparison between a public and private sector tertiary hospital in Karachi, Pakistan
- 2024
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In: JOURNAL OF PAKISTAN MEDICAL ASSOCIATION. - : Pakistan Medical Association. - 0030-9982. ; 74:2, s. 366-369
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Journal article (peer-reviewed)abstract
- Primary brain tumours (PBTs) are the commonest solid tumours in children and young people (CYP). A study was conducted at a private and a public sector hospital in Karachi, Pakistan, to determine the socio-demographic and tumour -related characteristics of CYP with PBTs between those presenting to the public and private hospitals. A total of 49 patients were included. The commonest PBT was pilocytic astrocytoma (29%). There were no differences in tumour -related characteristics between the two groups. However, parents of CYP with PBTs presenting to the public sector hospital were significantly less educated and had lower household incomes. No significant differences in age, gender, educational status, and ethnicity of CYP with PBTs were observed. Since CYP with PBTs presenting at the public sector hospital were from significantly lower socioeconomic backgrounds and their parents were less educated, it suggests socio-economic disparities in PBT care for CYPs in Karachi, Pakistan.
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| 2. |
- Zahid, Nida, et al.
(author)
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Psychosocial factors influencing quality of life in patients with primary brain tumors in Pakistan : an analytical cross-sectional study
- 2023
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In: BMC Research Notes. - : Springer Nature. - 1756-0500. ; 16:1
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Journal article (peer-reviewed)abstract
- ObjectiveDespite quality of life (QoL) being recognized as an important outcome in neuro-oncology, there is a lack of research from Pakistan where sociocultural differences may influence QoL. This study aimed to measure the QoL in patients with primary brain tumors (PBTs) and assess its association with mental health outcomes and social support.ResultsOur study included a total of 250 patients, with a median age of 42 years (range 33-54 years). The commonest brain tumors were glioma (46.8%) and meningioma (21.2). The mean global QoL of the sample was 75.73 +/- 14.9. The majority of patients had high social support (97.6%) and were not depressed (90%) or anxious (91.6%).On multivariable linear regression, global QoL was inversely associated with no or low income (beta coefficients: -8.75 to -11.84), having hypertension (-5.53), currently using a urine catheter (-13.55), having low social support (-28.16) suffering from mild (-15.31) or symptomatic (-23.84) depression, or mild anxiety (-13.22).
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| 3. |
- Zahid, Nida, et al.
(author)
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Socio-demographic and antenatal risk factors of brain tumor in children and young people : A matched case-control study from Karachi, Pakistan
- 2023
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In: Journal of Public Health Research. - : SAGE Publications. - 2279-9028 .- 2279-9036. ; 12:3
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Journal article (peer-reviewed)abstract
- Background:Brain tumors are a common cause of morbidity, disability, cognitive deterioration and mortality in children, even after treatment. Little is know about the specific causes. The study aimed to assess potential socio-demographic and antenatal factors in primary brain tumor (PBTs) in children and young people (CYP) in Karachi, Pakistan.Designs and methods:A single center hospital based matched case control study in Karachi, Pakistan. Cases were defined as CYP aged between 5 and 21 years with any histological type and grade of primary brain tumor of any histology, stage or grade. Data were collected from parents of 244 patients at the selected center between 2017 and 2021 via telephonic interview. Controls were 5-21 years old CYP admitted with non-oncological diagnoses matched on age and sex. Matched Odds Ratios for predictors of brain tumor in children were derived. Those of statistical significance were included in a multivariable logistic regression model.Results:In the adjusted model, lower paternal education (matched adjusted odds ratio (maOR) 2.46; 95% CI 1.09-5.55), higher household monthly income (maOR 3.4; 95% CI 1.1-10.2), antenatal paternal use of addictive substances (maOR 19.5; 95% CI 2.1-179.8), and antenatal maternal use of analgesics during pregnancy (maOR 3.0; 95% CI 1.2-7.9) were all independently predictive of brain tumors.Conclusion:This matched case-control study found novel associations between maternal use of analgesics, paternal use of addictive substances, higher household income, and lower paternal education and Primary Brain Tumors in Children and Young People. Longitudinal multicenter studies will be required to test these associations prospectively.
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