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- Didion, JP, et al.
(author)
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R2d2 Drives Selfish Sweeps in the House Mouse
- 2016
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In: Molecular biology and evolution. - : Oxford University Press (OUP). - 1537-1719 .- 0737-4038. ; 33:6, s. 1381-1395
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Journal article (peer-reviewed)
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| 3. |
- Bethlehem, RAI, et al.
(author)
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Brain charts for the human lifespan
- 2022
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 604:79057906, s. 525-
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Journal article (peer-reviewed)abstract
- Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
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| 7. |
- Jaarola, Maarit, et al.
(author)
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Molecular phylogeny of the speciose vole genus Microtus (Arvicolinae, Rodentia) inferred from mitochondrial DNA sequences
- 2004
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In: Molecular Phylogenetics and Evolution. - : Elsevier BV. - 1095-9513 .- 1055-7903. ; 33:3, s. 647-663
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Research review (peer-reviewed)abstract
- Voles of the genus Microtus represent one of the most speciose mammalian genera in the Holarctic. We established a molecular phylogeny for Microtus to resolve contentious issues of systematic relationships and evolutionary history in this genus. A total of 81 specimens representing ten Microtus species endemic to Europe as well as eight Eurasian, six Asian and one Holarctic species were sequenced for the entire cytochrome b gene (1140 bp). A further 25 sequences were retrieved from GenBank, providing data on an additional 23, mainly Nearctic, Microtus species. Phylogenetic analysis of these 48 species generated four well-supported monophyletic lineages. The genus Chionomys, snow voles, formed a distinct and well-supported lineage separate from the genus Microtus. The subgenus Microtus formed the strongest supported lineage with two sublineage displaying a close relationship between the arvalis species group (common voles) and the socialis species group (social voles). Monophyly of the Palearctic pitymyid voles, subgenus Terricola, was supported, and this subgenus was also subdivided into two monophyletic species groups. Together, these groupings clarify long-standing taxonomic uncertainties in Microtus. In addition, the "Asian" and the Nearctic lineages reported previously were identified although the latter group was not supported. However, relationships among the main Microtus branches were not resolved. suggesting a rapid and potentially Simultaneous radiation of a widespread ancestor early in the history of the genus. This and subsequent radiations discernible in the cytochrome b phylogeny, show the considerable potential of Microtus for analysis of historical and ecological determinants of speciation in small mammals. It is evident that speciation is an ongoing process in the genus and that the molecular data provides a vital insight into current species limits as well as cladogenic events of the past. (C) 2004 Elsevier Inc. All rights reserved.
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| 8. |
- Matson, Joseph R., et al.
(author)
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The Role of Optical Phonon Confinement in the Infrared Dielectric Response of III–V Superlattices
- 2023
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In: Advanced Materials. - : WILEY-V C H VERLAG GMBH. - 0935-9648 .- 1521-4095.
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Journal article (peer-reviewed)abstract
- Polar dielectrics are key materials of interest for infrared (IR) nanophotonic applications due to their ability to host phonon-polaritons that allow for low-loss, subdiffractional control of light. The properties of phonon-polaritons are limited by the characteristics of optical phonons, which are nominally fixed for most “bulk” materials. Superlattices composed of alternating atomically thin materials offer control over crystal anisotropy through changes in composition, optical phonon confinement, and the emergence of new modes. In particular, the modified optical phonons in superlattices offer the potential for so-called crystalline hybrids whose IR properties cannot be described as a simple mixture of the bulk constituents. To date, however, studies have primarily focused on identifying the presence of new or modified optical phonon modes rather than assessing their impact on the IR response. This study focuses on assessing the impact of confined optical phonon modes on the hybrid IR dielectric function in superlattices of GaSb and AlSb. Using a combination of first principles theory, Raman, FTIR, and spectroscopic ellipsometry, the hybrid dielectric function is found to track the confinement of optical phonons, leading to optical phonon spectral shifts of up to 20 cm−1. These results provide an alternative pathway toward designer IR optical materials.
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| 9. |
- Rashid, Md. Jayedur, 1979-
(author)
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Extending a networked robot system to include humans, tiny devices, and everyday objects
- 2011
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Doctoral thesis (other academic/artistic)abstract
- In networked robot systems (NRS), robots and robotic devices are distributed in the environment; typically tasks are performed by cooperation and coordination of such multiple networked components. NRS offer advantages over monolithic systems in terms of modularity, flexibility and cost effectiveness, and they are thus becoming a mainstream approach to the inclusion of robotic solutions in everyday environments. The components of a NRS are usually robots and sensors equipped with rich computational and communication facilities. In this thesis, we argue that the capabilities of a NRS would greatly increase if it could also accommodate among its nodes simpler entities, like small ubiquitous sensing and actuation devices, home appliances, or augmented everyday objects. For instance, a domestic robot needs to manipulate food items and interact with appliances. Such a robot would benefit from the ability to exchange information with those items and appliances in a direct way, in the same way as with other networked robots and sensors. Combining such highly heterogeneous devices inside one NRS is challenging, and one of the major challenges is to provide a common communication and collaboration infrastructure. In the field of NRS, this infrastructure is commonly provided by a shared middleware. Unfortunately, current middlewares lack the generality needed to allow heterogeneous entities such as robots, simple ubiquitous devices and everyday objects to coexist in the same system. In this thesis we show how an existing middleware for NRS can be extended to include three new types of “citizens” in the system, on peer with the other robots. First, we include computationally simple embedded devices, like ubiquitous sensors and actuators, by creating a fully compatible tiny version of the existing robotic middleware. Second, we include augmented everyday objects or home appliances which are unable to run the middleware on board, by proposing a generic design pattern based on the notion of object proxy. Finally,we go one step further and include humans as nodes in the NRS by defining the notion of human proxy. While there exist a few other NRS which are able to include both robots and simple embedded devices in the same system, the use of proxies to include everyday objects and humans in a generic way is a unique feature of this work. In order to verify and validate the above concepts, we have implemented them in the Peis-Ecology NRS model. We report a number of experiments based on this implementation, which provide both quantitative and qualitative evaluations of its performance, reliability, and interoperability.
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- Rask-Andersen, Mathias, et al.
(author)
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Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats
- 2012
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In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 20:2, s. 192-197
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Journal article (peer-reviewed)abstract
- Genome-wide association studies have shown a strong association of single-nucleotide polymorphisms (SNPs) in the near vicinity of the TMEM18 gene. The effects of the TMEM18-associated variants are more readily observed in children. TMEM18 encodes a 3TM protein, which locates to the nuclear membrane. The functional context of TMEM18 and the effects of its associated variants are as of yet undetermined. To further explore the effects of near-TMEM18 variants, we have genotyped two TMEM18-associated SNPs, rs6548238 and rs4854344, in a cohort of 2352 Greek children (Healthy Growth Study). Included in this study are data on anthropomorphic traits body weight, BMI z-score and waist circumference. Also included are dietary energy and macronutrient intake as measured via 24-h recall interviews. Major alleles of rs6548238 and rs4854344 were significantly associated with an increased risk of obesity (odds ratio=1.489 (1.161-1.910) and 1.494 (1.165-1.917), respectively), and positively correlated to body weight (P=0.017, P=0.010) and waist circumference (P=0.003, P=0.003). An association to energy and macronutrient intake was not observed in this cohort. We also correlated food intake and body weight in a food choice model in rats to Tmem18 expression in central regions involved in feeding behavior. We observed a strong positive correlation between TMEM18 expression and body weight in the prefrontal cortex (PFC) (r=0.5694, P=0.0003) indicating a potential role for TMEM18 in higher functions related to feeding involving the PFC.
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