| 1. |
- Jansen, Willemijn J, et al.
(author)
-
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- 2015
-
In: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:19, s. 1924-38
-
Journal article (peer-reviewed)abstract
- Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
|
|
| 2. |
- Bashiri, Farzana, et al.
(author)
-
Conceptualizing Scholar-Activism Through Scholar-Activist Accounts
- 2024. - 1
-
In: Making Universities Matter : Collaboration, Engagement, Impact - Collaboration, Engagement, Impact. - 2197-5698 .- 2197-5701. - 9783031487996 - 9783031487989 ; , s. 61-97
-
Book chapter (peer-reviewed)abstract
- This chapter delves into one of the ways in which scholars strive to make their work matter, namely, through the practice of scholar-activism. It becomes evident that the concept of scholar-activism is multifaceted and lacks a universally established definition. The objective of this chapter is to gain an insider’s understanding of scholar-activism by exploring its conceptualization and intellectual foundations. To achieve this, a conceptual review of literature authored by scholar-activists is conducted, complemented by scientometric analysis of co-wording and co-citation. The findings of this study reveal two key insights. First, the concept of scholar-activism can be viewed as comprising three interconnected components: criticality, active engagement, and normative orientation. These elements inform one another, shaping the overall practice of scholar-activism. Second, the review identifies four primary intellectual influences that underpin scholar-activism: critical geography, feminist thought, popular education, and critical social theory. It becomes apparent that, based on the accounts of scholar-activists in this review, a conceptual reconciliation between scholarship and activism is feasible. Nevertheless, the practical challenges of navigating institutional and contextual barriers to bring about this alignment remain a significant obstacle for scholar-activists, warranting further exploration.
|
|
| 3. |
|
|
| 4. |
- Benner, Mats, et al.
(author)
-
Foundations and the new renewal of research
- 2022
-
In: Smart Policies for Societies in Transition : The Innovation Challenge of Inclusion, Resilience and Sustainability - The Innovation Challenge of Inclusion, Resilience and Sustainability. ; , s. 213-227
-
Book chapter (peer-reviewed)
|
|
| 5. |
- Bignami, Francesca, et al.
(author)
-
Potential effects of increased openness in pharma : the original knowledge behind new drugs
- 2019
-
In: Drug Discovery Today. - : Elsevier BV. - 1359-6446 .- 1878-5832.
-
Journal article (peer-reviewed)abstract
- This study seeks to determine potential changes in the degree of openness in pharmaceutical R&D by investigating where the knowledge behind new molecular entities (NMEs) comes from in terms of type of organization, geography and time. We find that the organizations granted NMEs increasingly rely on external knowledge sources but that these are increasingly shared among NME grantees. Universities are the most important indirect knowledge contributor and their relative importance has increased with time. NME grantees are increasingly relying on knowledge from different countries and the age of the knowledge sources confirms that recent NMEs are mostly follow-on drugs. This work provides evidence of the increasing openness of pharma to new knowledge sources as a means to improving the drug discovery and development process.
|
|
| 6. |
- Bignami, Francesca, et al.
(author)
-
The importance of geographical distance to different types of R&D collaboration in the pharmaceutical industry
- 2020
-
In: Industry and Innovation. - : Informa UK Limited. - 1366-2716 .- 1469-8390. ; 27:5, s. 513-537
-
Journal article (peer-reviewed)abstract
- Innovation within companies is generated by a combination of different types of knowledge from external and geographically dispersed sources. Although the geographical dimension of collaboration has previously been investigated, studies have not distinguished between different types of knowledge involved in collaboration. This article analyses how the number of collaborations between pharmaceutical multinational companies (MNCs) and external organizations is affected by geographical distance, distinguishing between four knowledge types: basic science, clinical science, core knowledge, and exploration knowledge. We use co-publications as a proxy for collaborations. Our results show that collaborations in basic science and core knowledge areas are more negatively affected by geographical distance than collaborations within clinical science and exploration knowledge areas. This suggests that the importance of geographic proximity depends on the type of knowledge that is being transferred in R&D collaborations. Our results have implications for companies´ collaboration strategies and their choices for the R&D sites´ location.
|
|
| 7. |
- Jansen, Willemijn J, et al.
(author)
-
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
- 2018
-
In: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 75:1, s. 84-95
-
Journal article (peer-reviewed)abstract
- Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P=.16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P<.001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P<.001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited.
|
|
| 8. |
- Jansen, Willemijn J, et al.
(author)
-
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
- 2022
-
In: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 79:3, s. 228-243
-
Journal article (peer-reviewed)abstract
- One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
|
|
| 9. |
- Jonsson, Anna, et al.
(author)
-
Engaging in Societal Collaboration Through Reflexivity : Experiences from a Cross-Disciplinary Pilot Course for Faculty
- 2024
-
In: Making Universities Matter : Collaboration, Engagement. Impact - Collaboration, Engagement. Impact. - Cham : Springer. - 2197-5698 .- 2197-5701. - 9783031487996 - 9783031487989 ; , s. 11-32
-
Book chapter (peer-reviewed)abstract
- There is limited understanding of how education initiatives geared toward faculty and support staff can foster a capacity for long-term and integrated societal engagement and collaboration within higher education institutions. Using the experiences from a cross-disciplinary pilot course in Sweden, the current study aims to identify features that explicate how skills and academic rigor for engaging in societal collaboration can be developed toward a “reflexive scholarship of societal collaboration.” Based on a case study of the course, we identify the need for (i) theoretical orientation, (ii) collective reflections among diverse participants, and (iii) application of gained knowledge in real-world contexts. Building on the experiences from the pilot course, we explore and discuss the participants’ reflections on how their partaking in the course may support a reflexive scholarship of societal collaboration. Our study is relevant to managers and policymakers interested in nurturing long-term and integrated collaborations between academia and various societal actors.
|
|
| 10. |
-
Making Universities Matter : Collaboration, Engagement, Impact
- 2024
-
Editorial collection (peer-reviewed)abstract
- In an era of rapid change and increasing societal demands, the role of universities as knowledge producers and catalysts for change has come under scrutiny. This open access book offers a fresh perspective on the significance of universities in society, shedding light on how their knowledge can truly matter beyond academia.Drawing upon insightful inquiries from both the Swedish and international contexts, this volume delves into the multifaceted interactions between universities and various knowledge users, emphasizing the need for scholars to reflect on how their knowledge can become useful and applicable to wider society.Organized into three compelling themes, collaboration, engagement, and impact, this book explores the concept of "mattering". Together and jointly, they point at the fluid movement of scholars and scholarly knowledge across academic, political, and public spaces, and the intentional actions of scientists to leverage their expertise for real-world impact. Essential reading for social science and humanities scholars, university management professionals, and individuals keen on a critical understanding of the evolving role of universities, this volume offers a comprehensive examination of how universities have mattered, continue to matter, and can shape the future.
|
|
