| 1. |
- Shirai, K., et al.
(author)
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Graft linker immobilization for spatial control of antibody immobilization inside fused microchips
- 2009
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In: Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. - : Chemical and Biological Microsystems Society. - 9780979806421 ; , s. 1566-1568
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Conference paper (peer-reviewed)abstract
- A new method for antibody immobilization to the inside of fused silica microchips coated with a protein repelling polymer (2-methacryloyloxyethyl phosphorylcholine polymer, MPC polymer) is described. Antibody patterning is achieved by using a new photoreactive linker which is composed of three-parts: a carboxyl group (-COOH), a hydrophilic PEG spacer and a photoreactive benzophenone. The linker is grafted with UV which introduces free carboxyl groups to the microchannel surface. Antibodies are immobilized to these areas, by using amide bonding between protein -NH2's and linker's -COOH. Patterned anti-BSA antibodies retained functionality and were capable of antigen specific capture.
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| 2. |
- Argurio, Riccardo, 1972, et al.
(author)
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Collider signatures of goldstini in gauge mediation
- 2012
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2012:6
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Journal article (peer-reviewed)abstract
- We investigate the collider signatures of the multiple goldstini scenario in the framework of gauge mediation. This class of models is characterized by a visible sector (e.g. the MSSM or any extension) coupled by gauge interactions to more than one SUSY breaking sector. The spectrum consists of a light gravitino LSP, behaving as a goldstino, and a number of neutral fermions (the pseudo-goldstini) with a mass between that of the LSP and that of the lightest particle of the observable sector (LOSP). We consider the two situations where the LOSP is either a gaugino-like neutralino or a stau and we assume only one pseudo-goldstino of a mass of O(100) GeV. The coupling of the LOSP to the pseudo-goldstino can be enhanced with respect to those of the gravitino giving rise to characteristic signatures. We show that the decay modes of the LOSP into a SM particle and a pseudo-goldstino can be significant. For both LOSP scenarios we analyze (pseudo)-goldstini production at colliders. Compared to standard gauge mediation the final state spectrum is softer and more structured.
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| 3. |
- D'Hondt, J., et al.
(author)
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Multilepton signals of gauge mediated supersymmetry breaking at the LHC
- 2014
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In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 731, s. 7-12
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Journal article (peer-reviewed)abstract
- We investigate multilepton LHC signals arising from electroweak processes involving sleptons. We consider the framework of general gauge mediated supersymmetry breaking, focusing on models where the low mass region of the superpartner spectrum consists of the three generations of charged sleptons and the nearly massless gravitino. We demonstrate how such models can provide an explanation for the anomalous four lepton events recently observed by the CMS Collaboration, while satisfying other existing experimental constraints. The best fit to the CMS data is obtained for a selectron/smuon mass of around 145 GeV and a stau mass of around 90 GeV. These models also give rise to final states with more than four leptons, offering alternative channels in which they can be probed and we estimate the corresponding production rates at the LHC. (c) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
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| 4. |
- Xi, H., et al.
(author)
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Towards single molecule detection in minute volumes - UV-grafted dna probes with padlock probe detection and RCA amplification
- 2009
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In: Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. - : Chemical and Biological Microsystems Society. - 9780979806421 ; , s. 1554-1556
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Conference paper (peer-reviewed)abstract
- The technique of Immobilizing DNA in extended nano-space (10-1000 nm) was developed. This technique can be used for rolling circle amplification (RCA) and will finally make single DNA detection and nano-immunoassay possible. Here, we combine UV-mediated immobilization to DNA, examine two different methods for immobilization, and couple to padlock probe and RCA. Detection of fluorescence labeled DNA hybridization to RCA demonstrated that DNA analysis in minute volumes succeeded. Our technique can be served to detect single DNA, and we are developing this technique in extended nano-sapce to define the mechnisms of DNA amplification by record RCA in real time.
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| 5. |
- Bakx, Tom J. L. C., et al.
(author)
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ALMA uncovers the [C II] emission and warm dust continuum in a z=8.31 Lyman break galaxy
- 2020
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In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 493:3, s. 4294-4307
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Journal article (peer-reviewed)abstract
- We report on the detection of the [C II] 157.7 mu m emission from the Lyman break galaxy (LBG) MACS0416_Y1 at z = 8.3113, by using the Atacama Large Millimeter/submillimeter Array (ALMA). The luminosity ratio of [O III] 88 mu m (from previous campaigns) to [CII] is 9.3 +/- 2.6, indicative of hard interstellar radiation fields and/or a low covering fraction of photodissociation regions. The emission of [C II] is cospatial to the 850 mu m dust emission (90 mu m rest frame, from previous campaigns), however the peak [C II] emission does not agree with the peak [O III] emission, suggesting that the lines originate from different conditions in the interstellar medium. We fail to detect continuum emission at 1.5 mm (160 mu m rest frame) down to 18 mu Jy (3 sigma). This non-detection places a strong limits on the dust spectrum, considering the 137 +/- 26 mu Jy continuum emission at 850 mu m. This suggests an unusually warm dust component (T > 80 K, 90 per cent confidence limit), and/or a steep dust-emissivity index (beta(dust) > 2), compared to galaxy-wide dust emission found at lower redshifts (typically T similar to 30-50 K, beta(dust) similar to 1-2). If such temperatures are common, thiswould reduce the required dust mass and relax the dust production problem at the highest redshifts. We therefore warn against the use of only single-wavelength information to derive physical properties, recommend a more thorough examination of dust temperatures in the early Universe, and stress the need for instrumentation that probes the peak of warm dust in the Epoch of Reionization.
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| 6. |
- Binggeli, Christian, et al.
(author)
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A puzzling non-detection of [O III] and [C II] from a z ≈ 7.7 galaxy observed with ALMA
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 646
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Journal article (peer-reviewed)abstract
- Context. Characterizing the galaxy population in the early Universe holds the key to understanding the evolution of these objects and the role they played in cosmic reionization. However, there have been very few observations at the very highest redshifts to date. Aims. In order to shed light on the properties of galaxies in the high-redshift Universe and their interstellar media, we observe the Lyman-α emitting galaxy z7_GSD_3811 at z = 7.664 with bands 6 and 8 at the Atacama Large Millimeter/submillimeter Array (ALMA). Methods. We target the far-infrared [O iii] 88 µm and [C ii] 158 µm emission lines and dust continuum in the star-forming galaxy z7_GSD_3811 with ALMA. We combine these measurements with earlier observations in the rest-frame ultraviolet (UV) in order to characterize the object and compare the results to those of earlier studies that observed [O iii] and [C ii] emission in high-redshift galaxies. Results. The [O iii] 88 µm and [C ii] 158 µm emission lines are undetected at the position of z7_GSD_3811, with 3σ upper limits of 1.6 × 108 L and 4.0 × 107 L, respectively. We do not detect any dust continuum in band 6 nor band 8. The measured rms in the band 8 and band 6 continua are 26 and 9.9 µJy beam−1, respectively. Similar to several other high-redshift galaxies, z7_GSD_3811 exhibits low [C ii] emission for its star formation rate compared to local galaxies. Furthermore, our upper limit on the [O iii] line luminosity is lower than the previously observed [O iii] lines in high-redshift galaxies with similar UV luminosities. Our ALMA band 6 and 8 dust continuum observations imply that z7_GSD_3811 likely has a low dust content, and our non-detections of the [O iii] and [C ii] lines could indicate that z7_GSD_3811 has a low metallicity (Z. 0.1 Z).
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| 7. |
- Binggeli, Christian, et al.
(author)
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Balmer breaks in simulated galaxies at z > 6
- 2019
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In: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 489:3, s. 3827-3835
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Journal article (peer-reviewed)abstract
- Photometric observations of the spectroscopically confirmed z approximate to 9.1 galaxy MACS1149-JD1 have indicated the presence of a prominent Balmer break in its spectral energy distribution, which may be interpreted as due to very large fluctuations in its past star formation activity. In this paper, we investigate to what extent contemporary simulations of high-redshift galaxies produce star formation rate variations sufficiently large to reproduce the observed Balmer break of MACS1149-JD1. We find that several independent galaxy simulations are unable to account for Balmer breaks of the inferred size, suggesting that MACS1149-JD1 either must be a very rare type of object or that our simulations are missing some key ingredient. We present predictions of spectroscopic Balmer break strength distributions for z approximate to 7-9 galaxies that may be tested through observations with the upcoming James Webb Space Telescope and also discuss the impact that various assumptions on dust reddening, Lyman continuum leakage, and deviations from a standard stellar initial mass function would have on the results.
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| 8. |
- Ferretti, Gabriele, 1963, et al.
(author)
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Multiphoton signatures of goldstini at the LHC
- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 2014:4
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Journal article (peer-reviewed)abstract
- We study models of gauge mediated SUSY breaking with more than one hidden sector. In these models the neutralino sector of the MSSM is supplemented with additional light neutral fermions, the nearly massless gravitino and the massive pseudo-goldstini. For the case where the Bino is the lightest ordinary SUSY particle, its preferred decay is to a photon and the heaviest pseudo-goldstino, which generically cascades down to lighter pseudo-goldstini, or to the gravitino, in association with photons. This gives rise to multiphoton plus missing energy signatures at the LHC. We investigate in detail simplified models where the SUSY spectrum consists of the right-handed sleptons, a Bino-like neutralino, the pseudo-goldstini and the gravitino. We compare against existing LHC searches and show that the sensitivity to our models could be significantly improved by relaxing the kinematic cuts and requiring additional final state particles. We propose inclusive searches in the final state with at least three photons plus missing energy and in the final state with at least two photons plus two leptons plus missing energy, the former being sensitive to any production mode and the latter being optimized for slepton pair production. We show that they could lead to an observation (or strong constraints) already with the data set from LHC Run I, and present prospects for LHC Run II.
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| 9. |
- Hashimoto, Takuya, et al.
(author)
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Big Three Dragons: A z=7.15 Lyman-break galaxy detected in [Oiii] 88 mu m, [Cii] 158 mu m, and dust continuum with ALMA
- 2019
-
In: Publication of the Astronomical Society of Japan. - : Oxford University Press (OUP). - 2053-051X .- 0004-6264. ; 71:4
-
Journal article (peer-reviewed)abstract
- We present new ALMA observations and physical properties of a Lyman break galaxy at z = 7.15. Our target, B14-65666, has a bright ultra-violet (UV) absolute magnitude, M-UV approximate to -22.4, and has been spectroscopically identified in Ly alpha with a small rest-frame equivalent width of approximate to 4 angstrom. A previous Hubble Space TElescope (HST) image has shown that the target is composed of two spatially separated clumps in the rest-frame UV. With ALMA, we have newly detected spatially resolved [Oiii] 88 mu m, [Cii] 158 mu m, and their underlying dust continuum emission. In the whole system of B14-65666, the [Oiii] and [Cii] lines have consistent redshifts of 7.1520 +/- 0.0003, and the [Oiii] luminosity, (34.4 +/- 4.1)x 10(8)L(circle dot), is about three times higher than the [Cii] luminosity, (11.0 +/- 1.4) x 10(8)L(circle dot). With our two continuum flux densities, the dust temperature is constrained to be T-d approximate to 50-60K under the assumption of a dust emissivity index of beta(d) = 2.0-1.5, leading to a large total infrared luminosity of L-TIR approximate to 1 x 10(12)L(circle dot). Owing to our high spatial resolution data, we show that the [Oiii] and [Cii] emission can be spatially decomposed into two clumps associated with the two rest-frame UV clumps whose spectra are kinematically separated by approximate to 200kms(-1). We also find these two clumps have comparable UV, infrared, [Oiii], and [Cii] luminosities. Based on these results, we argue that B14-65666 is a starburst galaxy induced by a major merger. The merger interpretation is also supported by the large specific star formation rate (defined as the star formation rate per unit stellar mass), sSFR Gyr(-1), inferred from our SED fitting. Probably, a strong UV radiation field caused by intense star formation contributes to its high dust temperature and the [Oiii]-to-[Cii] luminosity ratio.
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| 10. |
- Hashimoto, Takuya, et al.
(author)
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The onset of star formation 250 million years after the Big Bang
- 2018
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In: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 557:7705, s. 392-395
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Journal article (peer-reviewed)abstract
- A fundamental quest of modern astronomy is to locate the earliest galaxies and study how they influenced the intergalactic medium a few hundred million years after the Big Bang(1-3). The abundance of star-forming galaxies is known to decline(4,5) from redshifts of about 6 to 10, but a key question is the extent of star formation at even earlier times, corresponding to the period when the first galaxies might have emerged. Here we report spectroscopic observations of MACS1149-JD1(6), a gravitationally lensed galaxy observed when the Universe was less than four per cent of its present age. We detect an emission line of doubly ionized oxygen at a redshift of 9.1096 +/- 0.0006, with an uncertainty of one standard deviation. This precisely determined redshift indicates that the red rest-frame optical colour arises from a dominant stellar component that formed about 250 million years after the Big Bang, corresponding to a redshift of about 15. Our results indicate that it may be possible to detect such early episodes of star formation in similar galaxies with future telescopes.
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