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Search: WFRF:(Mayr Philipp)

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1.
  • Abramo, Giovanni, et al. (author)
  • Retraction of Predatory publishing in Scopus : evidence on cross-country differences lacks justification
  • 2023
  • In: Scientometrics. - : Springer Science and Business Media LLC. - 0138-9130 .- 1588-2861. ; 128:2, s. 1459-1461
  • Journal article (peer-reviewed)abstract
    • As members of the Distinguished Reviewers Board of Scientometrics and/or as recipients of the Derek de Solla Price Medal, we wish to express our disagreement with the retraction of the paper “Predatory publishing in Scopus: evidence on cross-country differences” co-authored by Vít Macháček and Martin Srholec (Macháček & Srholec, 2021a). The retraction was discussed in the blog Retraction Watch (Oransky, 2021), where important information about the context of the retraction was disclosed, including the pressure exerted by the publisher Frontiers on Scientometrics.
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2.
  • Hess, Timo, et al. (author)
  • Dissecting the genetic heterogeneity of gastric cancer
  • 2023
  • In: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
  • Journal article (peer-reviewed)abstract
    • Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO.Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level.Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO. 
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  • Result 1-5 of 5
Type of publication
journal article (3)
editorial proceedings (2)
Type of content
peer-reviewed (5)
Author/Editor
Mayr, Philipp (3)
Golub, Koraljka (2)
Nilsson, Magnus (1)
Abramo, Giovanni (1)
Aguillo, Isidro F. (1)
Aksnes, Dag W. (1)
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Boyack, Kevin (1)
Burrell, Quentin L. (1)
Campanario, Juan Mig ... (1)
Chinchilla-Rodríguez ... (1)
Costas, Rodrigo (1)
D’Angelo, Ciriaco An ... (1)
Harzing, Anne Wil (1)
Jamali, Hamid R. (1)
Larivière, Vincent (1)
Leydesdorff, Loet (1)
Luwel, Marc (1)
Martin, Ben (1)
McCain, Katherine W. (1)
Peters, Isabella (1)
Rafols, Ismael (1)
Robinson-Garcia, Nic ... (1)
Schubert, Torben (1)
Small, Henry (1)
Sugimoto, Cassidy R. (1)
Thelwall, Mike (1)
van den Besselaar, P ... (1)
van Leeuwen, Thed (1)
Waltman, Ludo (1)
Cancel-Tassin, Geral ... (1)
Kogevinas, Manolis (1)
Brenner, Hermann (1)
Adolfsson, Rolf (1)
Arndt, Volker (1)
Moreno, Victor (1)
Vieth, Michael (1)
Veits, Lothar (1)
Jakubowska, Anna (1)
Cannizzaro, Renato (1)
Hedenäs, Lars (1)
Metspalu, Andres (1)
Deleuze, Jean-Franco ... (1)
Hoffmann, Per (1)
Nöthen, Markus M (1)
Lindblad, Mats (1)
Elbe, Peter (1)
Schumacher, Johannes (1)
Lubinski, Jan (1)
Martin, Vicente (1)
Dabrowska, Justyna (1)
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University
Linnaeus University (2)
Umeå University (1)
Lund University (1)
Karolinska Institutet (1)
Swedish Museum of Natural History (1)
Language
English (5)
Research subject (UKÄ/SCB)
Social Sciences (3)
Natural sciences (1)
Medical and Health Sciences (1)

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