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- Bassinet, C., et al.
(author)
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Retrospective radiation dosimetry using OSL of electronic components: Results of an inter-laboratory comparison
- 2014
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In: Radiation Measurements. - : Elsevier BV. - 1879-0925 .- 1350-4487. ; 71, s. 475-479
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Journal article (peer-reviewed)abstract
- In the framework of the EU-FP7 MULTIBIODOSE project, two protocols using OSL of resistors removed from the circuit board of mobile phones were developed with the aim to use the resistors as fortuitous dosimeters in the event of a large scale radiological accident. This paper presents the results of an inter-laboratory comparison carried out under the umbrella of EURADOS. The two aims of this exercise were the validation of the MULTIBIODOSE protocols by a large number of laboratories and the dissemination of the method with the objective of preparing the basis for a network that could increase Europe's response capacity in the case of a mass casualty radiological emergency. Twelve institutes from eleven European countries and one institute from the USA, with various degrees of expertise in OSL dosimetry, took part in the OSL inter-laboratory comparison. Generally, a good agreement within uncertainties was observed between estimated and nominal doses. (C) 2014 Elsevier Ltd. All rights reserved.
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- Artigas Soler, María, et al.
(author)
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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
- 2011
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1082-90
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Journal article (peer-reviewed)abstract
- Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
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- Ainsbury, Elizabeth, et al.
(author)
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Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons
- 2017
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In: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 93:1, s. 99-109
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Journal article (peer-reviewed)abstract
- Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.
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- Gallina, Barbara, et al.
(author)
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Towards explainable, compliant and adaptive human-automation interaction
- 2021
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In: CEUR Workshop Proceedings. - : CEUR-WS.
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Conference paper (peer-reviewed)abstract
- AI-based systems use trained machine learning models to make important decisions in critical contexts. The EU guidelines for trustworthy AI emphasise the respect for human autonomy, prevention of harm, fairness, and explicability. Many successful machine learning methods, however, deliver opaque models where the reasons for decisions remain unclear to the end user. Hence, accountability and trust are difficult to ascertain. In this position paper, we focus on AI systems that are expected to interact with humans and we propose our visionary architecture, called ECA-HAI (Explainable, Compliant and Adaptive Human-Automation Interaction)-RefArch. ECA-HAI-RefArch allows for building intelligent systems where humans and AIs form teams, able to learn from data but also to learn from each other by playing “serious games”, for a continuous improvement of the overall system. Finally, conclusions are drawn.
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- Johnson, David, et al.
(author)
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Connecting digital cancer model repositories with markup : introducing TumorML version 1.0
- 2013
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In: ACM SIGBioinformatics Record. - New York : Association for Computing Machinery (ACM). - 2331-9291 .- 2159-1210. ; 3:3, s. 5-11
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Journal article (peer-reviewed)abstract
- The cancer research community requires a standardized way of describing mathematical and computational models to enable interoperation between systems, repositories, and between the models themselves. In this paper we describe a new markup language, TumorML, for describing computational models that fall within the domain of cancer. TumorML is an XML-based markup language that wraps existing cancer model implementations with metadata for model curation, parametric interface description, implementation description, and compound model linking.In this paper we first introduce the rationale for a new markup language for computational cancer model description based on our experiences and requirements from the European Commission's 'Transatlantic Tumor Model Repositories' project. The aim of the project is to develop a European-based digital cancer model repository to link and interoperate with a similar established repository based in the United States. TumorML was developed to enable this interoperation between repositories. We introduce the language and describe the main features of the specification and go on to describe a real application of TumorML where a molecular pathway model has been packaged using the new markup language.
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