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- Kapur, Rick, et al.
(author)
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T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10
- 2017
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 129:18, s. 2557-2569
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Journal article (peer-reviewed)abstract
- Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4+CD25+FoxP3+ T regulatory cells (Tregs) and CD11c+ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion.
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- Sandborg, Michael, 1961-, et al.
(author)
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Demonstration of correlations between clinical and physical image quality measures in chest and lumbar spine screen-film radiography
- 2001
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In: British Journal of Radiology. - : British Institute of Radiology. - 0007-1285 .- 1748-880X. ; 74:882, s. 520-528
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Journal article (peer-reviewed)abstract
- The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between the two are derived. Clinical assessment has been made by a group of expert radiologists who evaluated fulfilment of the European image criteria for chest and lumbar spine radiography using two scoring methods: image criteria score (ICS) and visual grading analysis score (VGAS). Physical image quality measures were calculated using a Monte Carlo simulation model of the complete imaging system. This model includes a voxelized male anatomy and was used to calculate contrast and signal-to-noise ratio of various important anatomical details and measures of dynamic range. Correlations between the physical image quality measures on the one hand and the ICS and VGAS on the other were sought. 16 chest and 4 lumbar spine imaging system configurations were compared in frontal projection. A statistically significant correlation with clinical image quality was found in chest posteroanterior radiography for the contrast of blood vessels in the retrocardiac area and a measure of useful dynamic range. In lumbar spine anteroposterior radiography, a similar significant correlation with clinical image quality was found between the contrast and signal-to-noise ratio of the trabecular structures in the L1-L5 vertebrae. The significant correlation shows that clinical image quality can, at least in some cases, be predicted from appropriate measures of physical image quality.
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- Viscarra Rossel, R. A., et al.
(author)
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Field measurements of soil pH and lime requirement using an on-the-go Soil pH and Lime Requirement Measurement System
- 2005
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In: Precision Agriculture 2005, ECPA 2005. ; , s. 511-520
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Conference paper (peer-reviewed)abstract
- Further adoption and implementation of precision agriculture (PA) requires the development of proximal on-the-go sensing systems. Recently, an on-the-go Soil pH and Lime Requirement Measurement System (SpHLRMS) prototype was developed in a collaborative project between the Australian Centre for Precision Agriculture (ACPA), the Swedish Institute for Agricultural and Environmental Engineering (JTI) and Computronics Holdings Ltd. The system is made up of a soil sampling and sieving mechanism, a soil analytical component with a pH ISFET (Ion Sensitive Field Effect Transistor) used to measure changes in soil pH and data collection and measurement algorithms. The system measures soil pH and lime requirement. This paper reports the results from field testing of the first prototype of the SpHLRMS. The accuracies of soil pH measurements in 0.01M CaCl2 and in deionised H2O were 0.37 and 0.6 pH units, respectively. The accuracy of estimated lime requirements was 0.6 Mg/ha. A number of improvements to the system are still needed but these first results are promising.
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