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Search: WFRF:(Mechelen Lenny)

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  • Xu, Hui, et al. (author)
  • Antigen Conjugated to Anti-CD23 Antibodies is Rapidly Transported to Splenic Follicles by Recirculating B Cells
  • 2015
  • In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 81:1, s. 39-45
  • Journal article (peer-reviewed)abstract
    • IgE-antigen complexes, administered intravenously to mice, induce a several 100-fold higher specific antibody response than antigen alone. Additionally, in vivo activation and proliferation of specific CD4(+) T cells is enhanced. The mechanism behind these effects is thought to be that peripheral B cells capture IgE-antigen complexes via their low-affinity receptor for IgE, CD23, and rapidly transport them to splenic B cell follicles where an immune response is initiated. Here, we demonstrate that ovalbumin, covalently coupled to anti-CD23 antibodies and administered intravenously to mice, is also transported to splenic follicles and induces an enhanced primary antibody response. These effects are absent in CD23-deficient mice. No enhanced induction of immunological memory was observed. These findings extend previous observations regarding the in vivo role of CD23 and emphasize that recirculating B cells play an important role in antigen transport to the spleen.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Heyman, Birgitta (2)
Xu, Hui (2)
Henningsson, Frida (2)
Mechelen, Lennyvan (1)
Mechelen, Lenny (1)
van Mechelen, Lenny (1)
University
Uppsala University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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