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Träfflista för sökning "WFRF:(Meier Ina C.) "

Search: WFRF:(Meier Ina C.)

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  • Fischer, Benjamin, et al. (author)
  • A complete workflow for the differentiation and the dissociation of hiPSC-derived cardiospheres
  • 2018
  • In: Stem Cell Research. - : Elsevier. - 1873-5061 .- 1876-7753. ; 32, s. 65-72
  • Journal article (peer-reviewed)abstract
    • Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are an invaluable tool for both basic and translational cardiovascular research. The potential that these cells hold for therapy, disease modeling and drug discovery is hampered by several bottlenecks that currently limit both the yield and the efficiency of cardiac induction. Here, we present a complete workflow for the production of ready-to-use hiPSC-CMs in a dynamic suspension bioreactor. This includes the efficient and highly reproducible differentiation of hiPSCs into cardiospheres, which display enhanced physiological maturation compared to static 3D induction in hanging drops, and a novel papain-based dissociation method that offers higher yield and viability than the broadly used dissociation reagents TrypLE and Accutase. Molecular and functional analyses of the cardiomyocytes reseeded after dissociation confirmed both the identity and the functionality of the cells, which can be used in down-stream applications, either as monolayers or spheroids.
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  • Mohamed, Awaz, et al. (author)
  • Securing Nature's Contributions to People requires at least 20%-25% (semi-)natural habitat in human-modified landscapes
  • 2024
  • In: One Earth. - 2590-3330 .- 2590-3322. ; 7:1
  • Journal article (peer-reviewed)abstract
    • The cascading effects of biodiversity decline on human well-being present a pressing challenge for sustainable development. Conservation efforts often prioritize safeguarding specific species, habitats, or intact ecosystems but overlook biodiversity's fundamental role in providing Nature's Contributions to People (NCP) in human -modified landscapes. Here, we systematically review 154 peer -reviewed studies to estimate the minimum levels of (semi -)natural habitat quantity, quality, and spatial configuration needed in human -modified landscapes to secure functional integrity essential for sustaining NCP provision. We find that the provision of multiple NCP is threatened when (semi -)natural habitat in the landscape falls below an area of 20%- 25% for each km2. Five NCP almost completely disappear below a level of 10% habitat. The exact quantity, quality, and spatial configuration of habitat required depends on local context and specific NCP. Today, about two-thirds of human -modified lands have insufficient (semi -)natural habitat, requiring action for NCP regeneration. Our findings serve as a generic guideline to target conservation actions outside natural areas.
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