↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Meinecke AK) "

Search: WFRF:(Meinecke AK)

Result 1-3 of 3

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Corbalan, R, et al. (author) Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation: A Report From the GARFIELD-AF Registry 2019 In: JAMA cardiology. - : American Medical Association (AMA). - 2380-6591 .- 2380-6583. ; 4:6, s. 526-548 Journal article (peer-reviewed)
2.	Kantari-Mimoun, C, et al. (author) Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice 2017 In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:9, s. 15085-15100 Journal article (peer-reviewed)
3.	Meinecke, AK, et al. (author) Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis 2012 In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 119:24, s. 5931-5942 Journal article (peer-reviewed)abstract Pulmonary fibrosis is a progressive disease with unknown etiology that is characterized by extensive remodeling of the lung parenchyma, ultimately resulting in respiratory failure. Lymphatic vessels have been implicated with the development of pulmonary fibrosis, but the role of the lymphatic vasculature in the pathogenesis of pulmonary fibrosis remains enigmatic. Here we show in a murine model of pulmonary fibrosis that lymphatic vessels exhibit ectopic mural coverage and that this occurs early during the disease. The abnormal lymphatic vascular patterning in fibrotic lungs was driven by expression of platelet-derived growth factor B (PDGF-B) in lymphatic endothelial cells and signaling through platelet-derived growth factor receptor (PDGFR)–β in associated mural cells. Because of impaired lymphatic drainage, aberrant mural cell coverage fostered the accumulation of fibrogenic molecules and the attraction of fibroblasts to the perilymphatic space. Pharmacologic inhibition of the PDGF-B/PDGFR-β signaling axis disrupted the association of mural cells and lymphatic vessels, improved lymphatic drainage of the lung, and prevented the attraction of fibroblasts to the perilymphatic space. Our results implicate aberrant mural cell recruitment to lymphatic vessels in the pathogenesis of pulmonary fibrosis and that the drainage capacity of pulmonary lymphatics is a critical mediator of fibroproliferative changes.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-3 of 3

Refine your search

Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Gjertsen, E (1); Chen, X. (1); Endo, M. (1); Ferrer, A. (1); Fournier, D. (1); Hirose, M. (1); show more...; Howard, J. (1); Jackson, P. (1); Kim, H. (1); Kobayashi, T. (1); Lee, H. (1); Li, H. (1); Li, L. (1); Liu, B. (1); Love, J. (1); Mueller, K. (1); Mueller, T. (1); Nakamura, T. (1); Nielsen, J. (1); Nowak, S. (1); Takeda, H. (1); Yamaguchi, H. (1); Yamamoto, K. (1); Zhang, R. (1); Haas, S. (1); Mazur, M. (1); Novakova, J. (1); Patel, N. (1); Davies, E (1); Saito, T (1); Suzuki, S (1); Nikolaev, K. (1); Mori, T. (1); Kuznetsova, E. (1); Li, J. (1); Lutz, G. (1); Wright, D. (1); Kumar, S (1); Zhang, Y. (1); Clark, M. (1); Sharma, S. (1); Gustavsson, M (1); Kato, Y. (1); Ross, A. (1); Schwarz, T. (1); Wilson, P. (1); Yoshida, T. (1); Berge, T. (1); Dominguez, I. (1); Jacobs, P. (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view