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Search: WFRF:(Meletis J)

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  • Forsberg, M, et al. (author)
  • Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene
  • 2010
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 107:33, s. 14657-14661
  • Journal article (peer-reviewed)abstract
    • Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.
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  • Carlen, M, et al. (author)
  • Genetic visualization of neurogenesis
  • 2006
  • In: Experimental cell research. - : Elsevier BV. - 0014-4827. ; 312:15, s. 2851-2859
  • Journal article (peer-reviewed)
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  • Result 1-10 of 24

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