| 1. |
- Aad, G., et al.
(author)
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- 2012
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :12
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Journal article (peer-reviewed)
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| 2. |
- Tkachuk, Artem, et al.
(author)
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A new powerful method for site-specific transgene stabilization based on chromosomal double-strand break repair.
- 2011
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:10
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Journal article (peer-reviewed)abstract
- Transgenic insects are a promising tool in sterile insect techniques and population replacement strategies. Such transgenic insects can be created using nonautonomous transposons, which cannot be transferred without a transposase source. In biocontrol procedures where large numbers of insects are released, there is increased risk of transgene remobilization caused by external transposase sources that can alter the characteristics of the transgenic organisms lead horizontal transgene transfer to other species. Here we describe a novel, effective method for transgene stabilization based on the introduction of directed double-strand breaks (DSB) into a genome-integrated sequence and their subsequent repair by the single-strand annealing (SSA) pathway. Due to the construct's organization, the repair pathway is predictable, such that all transposon and marker sequences can be deleted, while preserving integration of exogenous DNA in the genome. The exceptional conservation of DNA repair pathways makes this method suitable for a broad range of organisms.
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| 3. |
- Sansone, Cinzia, et al.
(author)
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Critical Operations Capabilities and Reshoring Drivers in a High-Cost Environment
- 2021
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In: Transdisciplinary Engineering for Resilience: Responding to System Disruptions. - Amsterdam : IOS Press. - 9781643682082 - 9781643682099 ; , s. 263-271
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Conference paper (peer-reviewed)abstract
- Reshoring of manufacturing to high-cost environments has been gaining attention. Several drivers are usually involved in the reshoring process. This process also requires manufacturing companies to assess their capabilities in relationship to the reshoring drivers. However, the connection between the reshoring drivers and the capabilities that the manufacturing companies have in high-cost environments has received little attention. The purpose of this study is to investigate the connection between the reshoring drivers and critical capabilities, through a transdisciplinary approach. This study was conducted through a literature review. The first step included the investigation of existing literature related to operations capabilities. The second step included the investigation of existing literature related to reshoring drivers. The third step included an investigation of the link between the critical operations capabilities and the reshoring drivers derived from the literature. Both sets of critical operations capabilities and reshoring drivers were linked based on their respective definitions. The findings revealed that there is a connection between operations capabilities and reshoring drivers. This study contributes to the development of both reshoring and operations capabilities research streams, and to practice by identifying the specific operations capabilities that can drive reshoring.
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| 4. |
- Pérez Izquierdo, Leticia, et al.
(author)
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Fungal community of forest soil: diversity, functions and services
- 2021
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In: Forest Microbiology Volume 1: Tree Microbiome: Phyllosphere, Endosphere and Rhizosphere. - 9780128225424 ; , s. 231-255
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Book chapter (peer-reviewed)abstract
- Forest soil fungal communities are extremely complex and diverse, and show a range of different lifestyles from saprotrophs, endophytes, pathogens, and mycorrhizal species. These belowground communities are differently distributed through space and time scales, and they are involved in key ecosystem processes such as plant community dynamics, belowground trophic interactions, and biogeochemical cycles. Through examples from different global forest ecosystems, we describe the principal abiotic and biotic factors, including natural disturbances, driving the assemblage of fungal communities in forest soils, as well as potential underlying mechanisms. We have selected research studies directed at understanding how soil fungi activities and interactions impact forest functioning and can influence the goods and services provided by these ecosystems. Finally, we show how anthropic factors shape fungal communities and, in return, how soil fungi can be better integrated in forest practices to improve ecosystem services in the upcoming decades.
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| 5. |
- Antonakoglou, Konstantinos, et al.
(author)
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On the needs and requirements arising from connected and automated driving
- 2020
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In: Journal of Sensor and Actuator Networks. - : MDPI AG. - 2224-2708. ; 9:2
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Journal article (peer-reviewed)abstract
- Future 5G systems have set a goal to support mission-critical Vehicle-to-Everything (V2X) communications and they contribute to an important step towards connected and automated driving. To achieve this goal, the communication technologies should be designed based on a solid understanding of the new V2X applications and the related requirements and challenges. In this regard, we provide a description of the main V2X application categories and their representative use cases selected based on an analysis of the future needs of cooperative and automated driving. We also present a methodology on how to derive the network related requirements from the automotive specific requirements. The methodology can be used to analyze the key requirements of both existing and future V2X use cases.
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| 6. |
- Borgå, Olof, et al.
(author)
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Maximum Tolerated Dose and Pharmacokinetics of Paclitaxel Micellar in Patients with Recurrent Malignant Solid Tumours : A Dose-Escalation Study
- 2019
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In: Advances in Therapy. - : Springer. - 0741-238X .- 1865-8652. ; 36:5, s. 1150-1163
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Journal article (peer-reviewed)abstract
- Introduction: A water-soluble Cremophor EL-free formulation of paclitaxel, in which retinoic acid derivates solubilize paclitaxel by forming micelles (paclitaxel micellar), was studied for the first time in man to establish the maximum tolerated dose (MTD) and to characterize the pharmacokinetics (PK).Methods: This was an open-label, one-arm, dose-escalating study in patients with advanced solid malignant tumours, for which no standard therapy was available or had failed. Paclitaxel micellar was given as 1-h intravenous infusion every 21 days for 3 cycles, mainly without premedication. Plasma samples were collected during 24 h at the first cycle and paclitaxel concentrations were assayed by high-performance liquid chromatography. PK was evaluated using a two-compartment model.Results: Thirty-four patients received paclitaxel micellar at doses ranging between 90 and 275 mg/m2. MTD was established as 250 mg/m2. Fatigue and neuropathy were the most frequent dose-limiting toxicities. No hypersensitivity reactions were observed. PK of paclitaxel was evaluated in 25 data sets. Paclitaxel micellar had a rapid initial distribution phase, mean half-life 0.55 h, estimated to be completed 3 h after dosing and a mean terminal half-life of 8.8 h. Mean clearance was 13.4 L/h/m2 with fivefold interindividual variability. The residual areas after 10 h and 24 h were 15.7 ± 8.6% and 5.7 ± 3.9% of the area under the plasma concentration–time curve to infinite time (AUCinf), respectively.Conclusion: No new side effects unknown for paclitaxel were observed. Maximum plasma concentration (Cmax) and AUCinf showed a tendency to increase linearly with dose within the 150–275 mg/m2dose range. The possibility to administer paclitaxel micellar without steroid premedication makes it an attractive candidate for further studies in combination with immunotherapy.Trial Registration: EudraCT no: 2004-001821-54.
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| 7. |
- Connolly-Andersen, Anne-Marie, et al.
(author)
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Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever With Renal Syndrome A Self-Controlled Case Series Study
- 2014
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In: Circulation. - 0009-7322 .- 1524-4539. ; 129:12, s. 1295-1302
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Journal article (peer-reviewed)abstract
- Background We recently observed that cardiovascular causes of death are common in patients with hemorrhagic fever with renal syndrome (HFRS), which is caused by hantaviruses. However, it is not known whether HFRS is a risk factor for the acute cardiovascular events of acute myocardial infarction (AMI) and stroke. Methods and Results Personal identification numbers from the Swedish HFRS patient database (1997-2012; n=6643) were cross-linked with the National Patient Register from 1987 to 2011. Using the self-controlled case series method, we calculated the incidence rate ratio of AMI/stroke in the 21 days after HFRS against 2 different control periods either excluding (analysis 1) or including (analysis 2) fatal AMI/stroke events. The incidence rate ratios for analyses 1 and 2 for all AMI events were 5.53 (95% confidence interval [CI], 2.6-11.8) and 6.02 (95% CI, 2.95-12.3) and for first AMI events were 3.53 (95% CI, 1.25-9.96) and 4.64 (95% CI, 1.83-11.77). The incidence rate ratios for analyses 1 and 2 for all stroke events were 12.93 (95% CI, 5.62-29.74) and 15.16 (95% CI, 7.21-31.87) and for first stroke events were 14.54 (95% CI, 5.87-36.04) and 17.09 (95% CI, 7.49-38.96). The majority of stroke events occurred in the first week after HFRS. Seasonal effects were not observed, and apart from 1 study, neither sex nor age interacted with the associations observed in this study. Conclusions There is a significantly increased risk for AMI and stroke in the immediate time period after HFRS. Therefore, HFRS patients should be carefully monitored during the acute phase of disease to ensure early recognition of symptoms of impending AMI or stroke.
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| 8. |
- Jayaputera, G., et al.
(author)
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Adding value to marketplaces by assembling location-aware agents on-demand
- 2003
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In: Proceedings of the Second International Conference on Mobile Business. - Wien : Die Österreichische Computer Gesellschaft. - 3854031696
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Conference paper (peer-reviewed)abstract
- With the penetration of ubiquitous computing into physical marketplaces, requirements for software agents have increased also. The need for software agents at anytime, anyplace and helping the consumers with their shopping experience is becoming more obvious. Request from the consumers are changing all the time as well as the physical marketplace they are in (hence also the merchants). These conditions mean that a system that has a predefined number of agents; with each of them possessing a predefined set of functionality is not suitable for use. We propose a system, named eHermes, which assembles agents on-demand based on the user request and preferences. Such architecture supports dynamism and flexibility at run-time that are suitable for the pervasive computing environment. The main concept, called mission, and its abstract representation, called Task Decomposition Diagram, along with the eHermes architecture are presented in this paper. eHermes is currently being implemented on the Grasshopper agent toolkit.
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| 9. |
- Merila, J, et al.
(author)
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Cryptic evolution in a wild bird population
- 2001
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In: NATURE. - : MACMILLAN PUBLISHERS LTD. - 0028-0836. ; 412:6842, s. 76-79
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Journal article (peer-reviewed)abstract
- Microevolution is expected to be commonplace, yet there are few thoroughly documented cases of microevolution in wild populations(1,2). In contrast, it is often observed that apparently heritable traits under strong and consistent directional selection fa
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| 10. |
- Batra, A., et al.
(author)
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Analysis of Surface Roughness with 3D SAR Imaging at 1.5 THz
- 2023
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In: 2023 48TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES, IRMMW-THZ. - : Institute of Electrical and Electronics Engineers (IEEE). - 9798350336603
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Conference paper (peer-reviewed)abstract
- The expansion of the synthetic aperture radar (SAR) to the emerging THz spectrum has enabled a new era of applications in the areas of automobile, security, non-destructive testing, and material characterization. Thanks to the sub-mm wavelength, extraction of material surface properties is possible and of significant interest for the THz SAR applications. The properties define the surface scattering behavior, which is relational to the applied frequency. This study focuses on surface classification. We evaluate the scattering behavior of a rough surface and a smooth surface at 1.5 THz based on a SAR processing sequence that is introduced in this paper. First, we form the 3D SAR images of the metallic objects and then evaluate the surface properties based on the variation in the energy reflected by the object's surface.
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