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1.	Billaud, JN, et al. (author) Advantages to the use of rodent hepadnavirus core proteins as vaccine platforms 2007 In: Vaccine. - : Elsevier BV. - 0264-410X. ; 25:9, s. 1593-1606 Journal article (peer-reviewed)
2.	Billaud, JN, et al. (author) Combinatorial approach to hepadnavirus-like particle vaccine design 2005 In: Journal of virology. - 0022-538X. ; 79:21, s. 13656-13666 Journal article (peer-reviewed)
3.	Billaud, JN, et al. (author) Comparative antigenicity and immunogenicity of hepadnavirus core proteins 2005 In: Journal of virology. - 0022-538X. ; 79:21, s. 13641-13655 Journal article (peer-reviewed)
4.	Chen, Antony, et al. (author) Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination. 2011 In: Journal of immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 186:9, s. 5107-18 Journal article (peer-reviewed)abstract The hepatitis C virus (HCV)-specific T cell response in patients with chronic HCV is dysfunctional. In this study, we aimed at restoring immunological function through therapeutic vaccination in a transgenic mouse model with impaired HCV-specific T cell responses due to a persistent presence of hepatic HCV nonstructural (NS)3/4A Ags. The HCV-specific T cells have an actively maintained dysfunction reflected in reduced frequency, impaired cytokine production, and impaired effector function in vivo, which can be partially restored by blocking regulatory T cells or programmed cell death ligand 1. We hypothesized that the impairment could be corrected by including sequences that created a normal priming environment by recruiting "healthy" heterologous T cells and by activating innate signaling. Endogenously expressed hepatitis B core Ag (HBcAg) can recruit heterologous T cells and activate TLR (TLR7) signaling. Hence, by combining HCV NS3/4A with different forms of HBcAg we found that heterologous sequences somewhat improved activation and expansion of NS3/4A-specific T cells in a wild-type host. Importantly, the signals provided by HBcAg effectively restored the activation of HCV-specific T cells in a tolerant NS3/4A-transgenic mouse model. The adjuvant effect could also be transferred to the priming of dysfunctional HLA-A2-restricted NS3-specific T cells in vivo. Thus, recruiting healthy heterologous T cells to the site of priming may also help restore HCV-specific responses present in a chronically infected host.
5.	Chen, A, et al. (author) IMPROVING ON THE ABILITY OF ENDOGENOUS HEPATITIS B CORE ANTIGEN TO PRIME CYTOTOXIC T LYMPHOCYTES 2010 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 52, s. S239-S239 Conference paper (other academic/artistic)
6.	Chen, M, et al. (author) Human and murine antibody recognition is focused on the ATPase/helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein 1998 In: Hepatology (Baltimore, Md.). - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139. ; 28:1, s. 219-224 Journal article (peer-reviewed)
7.	Chen, M, et al. (author) Limited humoral immunity in hepatitis C virus infection 1999 In: Gastroenterology. - : Elsevier BV. - 0016-5085. ; 116:1, s. 135-143 Journal article (peer-reviewed)
8.	Sallberg, M, et al. (author) Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen 1998 In: Human gene therapy. - : Mary Ann Liebert Inc. - 1043-0342 .- 1557-7422. ; 9:12, s. 1719-1729 Journal article (peer-reviewed)

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Type of publication: journal article (7); conference paper (1)

Type of content: peer-reviewed (7); other academic/artistic (1)

Author/Editor: Sallberg, M (7); Peterson, D. (5); Milich, D (5); Chen, A. (4); Hughes, J (4); Jones, J. (3); show more...; Goldstein, P (3); Billaud, JN (3); Garduno, F (3); Sonnerborg, A (2); Chen, M (2); Weiland, O (2); Hultgren, C (2); Jin, L (2); Milich, DR (2); Birkett, A (2); McDowell, W (2); Maruyama, T. (1); Nystrom, J (1); Ahlen, G (1); Frelin, L (1); Peterson, DL (1); Ahlén, Gustaf (1); Chen, Antony (1); Frelin, Lars (1); Söderholm, Jonas, 19 ... (1); Sällberg, Matti (1); Koh, S (1); Lee, BO (1); Barr, M (1); Schodel, F (1); Mattsson, L. (1); Brass, Anette (1); Brenndörfer, Erwin D (1); Holmström, Fredrik (1); Chen, Margaret (1); Milich, David R (1); Fons, M (1); Alfonso, J (1); Chang, SM (1); Javadian, A (1); Ronlov, G (1); Townsend, K (1); Anderson, CG (1); O'Dea, J (1); Eason, R (1); Murthy, KK (1); Jolly, DJ (1); Mento, SJ (1); Lee, WT (1); show less...

University: Karolinska Institutet (8); University of Gothenburg (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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