| 1. |
- Ponten, Moa, et al.
(author)
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Association between expectations and clinical outcomes in online v. face-to-face therapy - an individual participant data meta-analysis
- 2024
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In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 54:6, s. 1207-1214
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Journal article (peer-reviewed)abstract
- Background. Online treatments are increasing in number and are currently available for a wide range of clinical problems. To date little is known about the role of treatment expectations and other placebo-like mechanisms in online settings compared to traditional face-to-face treatment. To address this knowledge gap, we analyzed individual participant data from randomized clinical trials that compared online and face-to-face psychological interventions.Methods. MEDLINE (Ovid) and PsycINFO (Ovid) were last searched on 2 February 2021. Randomized clinical trials of therapist guided online v. face-to-face psychological interventions for psychiatric or somatic conditions using a randomized controlled design were included. Titles, abstracts, and full texts of studies were independently screened by multiple observers. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline was followed. Authors of the matching trials were contacted for individual participant data. Ratings from the Credibility and Expectancy Questionnaire and the primary outcome measure from each trial were used to estimate the association between expectation ratings and treatment outcomes in online v. face-to-face interventions, using a mixed-effects model.Results. Of 7045 screened studies, 62 full-text articles were retrieved whereof six studies fulfilled the criteria and provided individual participant data (n = 491). Overall, CEQ ratings predicted clinical outcomes (beta = 0.27) at end of treatment with no moderating effect of treatment modality (online v. face-to-face).Conclusions. Online treatment appears to be equally susceptible to expectancy effects as face-to-face therapy. This furthers our understanding of the importance of placebo-like factors in online treatment and may aid the improvement of healthcare in online settings.
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| 2. |
- Zamora, Juan Carlos, et al.
(author)
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Considerations and consequences of allowing DNA sequence data as types of fungal taxa
- 2018
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In: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
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Journal article (peer-reviewed)abstract
- Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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| 3. |
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| 4. |
- Bendix, Marie, et al.
(author)
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Insulin and glucagon in plasma and cerebrospinal fluid in suicide attempters and healthy controls
- 2017
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In: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 81, s. 1-7
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Journal article (peer-reviewed)abstract
- Mental disorders and related behaviors such as suicidality and violence have been associated to dysregulation of e g carbohydrate metabolism. We hypothesized that patients after suicide attempt, compared to healthy controls, would have higher insulin and lower glucagon levels in plasma and cerebrospinal fluid and that these changes would be associated to violent behavior. Twenty-eight medication-free patients (10 women, 18 men), hospitalized after suicide attempt, and 19 healthy controls (7 women, 12 men) were recruited with the aim to study risk factors for suicidal behavior. Psychological/psychiatric assessment was performed with SCID I and II or the SCID interview for healthy volunteers respectively, the Karolinska Interpersonal Violence Scale (KIVS) for assessment of lifetime violence expression behavior, the Montgomery-Asberg-Depression-Scale (MADRS) and the Comprehensive Psychological Rating Scale (CPRS) for symptomatic assessment of depression and appetite. Fasting levels of insulin and glucagon were measured in plasma (P) and cerebrospinal fluid (CSF). Suicide attempters had higher insulin- and lower glucagon-levels in plasma- and CSF compared to controls. Except for P-glucagon these associations remained significant after adjusting for age and/or BMI. Patients reported significantly more expressed interpersonal violence compared to healthy volunteers. Expressed violence was significantly positively correlated with P- and CSF-insulin and showed a significant negative correlation with P-glucagon in study participants. These findings confirm and extend prior reports that higher insulin and lower glucagon levels in plasma and cerebrospinal fluid are associated with suicidal behavior pointing towards a potential autonomic dysregulation in the control of insulin and glucagon secretion in suicidal patients.
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| 5. |
- Johansson, Viktor, et al.
(author)
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A learning approach for feed-forward friction compensation
- 2018
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In: Proceedings of the 12th IFAC Symposium on Robot Control. - : Elsevier BV. ; , s. 412-417
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Conference paper (other academic/artistic)abstract
- An experimental comparison of two feed-forward based frictioncompensation methods is presented. The first method is based on theLuGre friction model, using identified friction model parameters, andthe second method is based on B-spline network, where the networkweights are learned from experiments. The methods are evaluated andcompared via experiments using a six axis industrial robot carryingout circular movements of different radii. The experiments show thatthe learning-based friction compensation gives an error reduction ofthe same magnitude as for the LuGre-based friction compensation.
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| 6. |
- Moberg, Louise, et al.
(author)
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Early menopause and weight loss are significant factors associated with risk of future fracture in middle-aged women
- 2022
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In: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 23:1
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Journal article (peer-reviewed)abstract
- BACKGROUND: To identify factors related to reproductive history and weight change associated with first incident fracture in middle-aged women.METHODS: In total, 18,326 women from the Malmö Diet and Cancer study were included in this prospective population-based cohort study. Participants were included 1991-1996 and followed to 2016. Using data from the National Patient Registry, linked with every participants' unique personal identification number, any first fracture affecting spine, thoracic cage, upper and lower extremities was identified. The association of baseline factors with incident fracture risk was analyzed using Cox regression models.RESULTS: For participating women, median age 56.0 years, the multivariable Cox regression analysis observed that early menopause (40-44 years) (hazard ratio (HR) 1.14, 95% confidence interval (CI) 1.03-1.27) but not premature menopause < 40 years (HR 1.06, 95% CI 0.91-1.24) was associated with future fracture risk. Self-reported weight loss since age 20 was also associated with future fracture risk (HR 1.39, 95% CI 1.17-1.65) whereas a daily alcohol consumption in the third quartile (5.36-11.42 g/day) compared to the lowest quartile (0-0.80 g/day) was associated with decreased future fracture risk (HR 0.88, 95% CI 0.81-0.96). The multivariable Cox regression analysis also observed that increasing age and weight at baseline, current smoking, a positive history of previous fracture and family history of fractures were associated with increased fracture risk whereas an increasing BMI was associated with a decreased fracture risk. No association to parity or period of lactation was observed nor ever-use of oral contraceptives and menopausal hormone therapy.CONCLUSION: This study shows that early menopause between 40 to 45 years and self-reported weight loss since age of 20 are relevant factors associated with increased fracture risk in middle-aged women. These factors were independent of traditional predictors of fracture risk among women and may be considered in preventive initiatives.TRIAL REGISTRATION: Clinicaltrials.gov with identifier: NCT04151732, since Nov 5th 2018.
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| 7. |
- Moberg, Viktor, et al.
(author)
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Chiral and achiral phosphine derivatives of alkylidyne tricobalt carbonyl clusters as catalyst precursors for (asymmetric) inter- and intramolecular Pauson-Khand reactions.
- 2008
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In: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9234 .- 1477-9226. ; :18, s. 2442-2453
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Journal article (peer-reviewed)abstract
- Phosphine derivatives of alkylidyne tricobalt carbonyl clusters have been tested as catalysts/catalyst precursors in intermolecular and (asymmetric) intramolecular Pauson-Khand reactions. A number of new phosphine derivatives of the tricobalt alkylidyne clusters [Co(3)(mu(3)-CR)(CO)(9)] (R = H, CO(2)Et) were prepared and characterised. The clusters [Co(3)(mu(3)-CR)(CO)(9-x)(PR'(3))(x)] (PR'(3) = achiral or chiral monodentate phosphine, x = 1-3) and [Co(3)(mu(3)-CR)(CO)(7)(P-P)] (P-P = chiral diphosphine; 1,1'- and 1,2-structural isomers) were assayed as catalysts for intermolecular and (asymmetric) intramolecular Pauson-Khand reactions. The phosphine-substituted tricobalt clusters proved to be viable catalysts/catalyst precursors that gave moderate to very good product yields (up to approximately 90%), but the enantiomeric excesses were too low for the clusters to be of practical use in the asymmetric reactions.
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| 8. |
- Moberg, Viktor
(author)
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Cluster-Based Catalysts for Asymmetric Synthesis.
- 2007
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Doctoral thesis (other academic/artistic)abstract
- In this work, the synthesis and characterisation of new low-valence transition metal carbonyl clusters, and an investigation into their viability to act as catalysts/catalyst precursors in asymmetric synthesis, are described. Carbonyl clusters based on ruthenium and osmium have been tested as (pre)catalysts for asymmetric hydrogenation of alpha-unsaturated carboxylic acids, and cobalt carbonyl clusters have been used as (pre)catalysts in (asymmetric) Pauson-Khand synthesis. The clusters [Os3(µ-H)2(CO)8(µ-1,2-P-P)] (x=1,2; P-P=chiral diphosphine) did not show any tendency to catalyse hydrogenation of the prochiral substrate tiglic acid. The new triosmium clusters were found to be generally inert and did not react with carbon monoxide or acetylene, or undergo hydride exchange with styrene-d8, all of which are reactions characteristic for the parent cluster [Os3(µ-H)2(CO)10]. Clusters of the type [H4Ru4(CO)12-2x(P-P)x] (x=1,2; P-P=chiral diphosphine) are viable as catalysts for (asymmetric) hydrogenation. Their reactivity strongly depends on the phosphine ligand coordinated. The reactivity of the ruthenium clusters derivatised with ferrocene-based chiral diphosphines showed a significant increase in reactivity compared to other clusters investigated. In the case of clusters coordinated with Walphos ligands, enantiomeric excess of >90 % was obtained in hydrogenation of tiglic acid. The Pauson-Khand reaction was catalysed by cobalt carbonyl clusters of the general formulae [Co3(µ3-CH)(CO)9-x(PR3)x] (x=1-3; PR3=achiral/chiral monophosphines) and Co3(µ3-CH)(CO)7(P-P) (P-P=chiral diphosphine). The clusters were tested both in the intermolecular and the asymmetric intramolecular versions of the Pauson-Khand reaction. In the asymmetric Pauson-Khand reaction, it was found that the clusters that gave the highest product yields also gave racemic mixtures. In contrast, the cluster that gave the lowest cyclopentenone yield (6%), [Co3(µ3-CH)(CO)7(CHIRAPHOS)] was able to generate the highest enantiomeric excess of 13 %. The absence of the original cobalt cluster after the catalytic tests indicates that the cobalt clusters act as catalyst precursors. Regardless of the nature of the active catalyst, the results obtained with these cluster-based catalytic systems are too poor to make these cobalt clusters of practical use in cyclopentenone synthesis.
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| 9. |
- Moberg, Viktor, et al.
(author)
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Efficient Cluster-Based Catalysts for Asymmetric Hydrogenation of α-Unsaturated Carboxylic Acids.
- 2012
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In: Chemistry: A European Journal. - : Wiley. - 1521-3765 .- 0947-6539. ; 18:39, s. 12458-12478
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Journal article (peer-reviewed)abstract
- The new clusters [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)], [H(4) Ru(4) (CO)(10) (1,1-P-P)] and [H(4) Ru(4) (CO)(11) (P-P)] (P-P=chiral diphosphine of the ferrocene-based Josiphos or Walphos ligand families) have been synthesised and characterised. The crystal and molecular structures of eleven clusters reveal that the coordination modes of the diphosphine in the [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)] clusters are different for the Josiphos and the Walphos ligands. The Josiphos ligands bridge a metal-metal bond of the ruthenium tetrahedron in the "conventional" manner, that is, with both phosphine moieties coordinated in equatorial positions relative to a triangular face of the tetrahedron, whereas the phosphine moieties of the Walphos ligands coordinate in one axial and one equatorial position. The differences in the ligand size and the coordination mode between the two types of ligands appear to be reflected in a relative propensity for isomerisation; in solution, the [H(4) Ru(4) (CO)(10) (1,1-Walphos)] clusters isomerise to the corresponding [H(4) Ru(4) (CO)(10) (μ-1,2-Walphos)] clusters, whereas the Josiphos-containing clusters show no tendency to isomerisation in solution. The clusters have been tested as catalysts for asymmetric hydrogenation of four prochiral α-unsaturated carboxylic acids and the prochiral methyl ester (E)-methyl 2-methylbut-2-enoate. High conversion rates (>94 %) and selectivities of product formation were observed for almost all catalysts/catalyst precursors. The observed enantioselectivities were low or nonexistent for the Josiphos-containing clusters and catalyst (cluster) recovery was low, suggesting that cluster fragmentation takes place. On the other hand, excellent conversion rates (99-100 %), product selectivities (99-100 % in most cases) and good enantioselectivities, reaching 90 % enantiomeric excess (ee) in certain cases, were observed for the Walphos-containing clusters, and the clusters could be recovered in good yield after completed catalysis. Results from high-pressure NMR and IR studies, catalyst poisoning tests and comparison of catalytic properties of two [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)] clusters (P-P=Walphos ligands) with the analogous mononuclear catalysts [Ru(P-P)(carboxylato)(2) ] suggest that these clusters may be the active catalytic species, or direct precursors of an active catalytic cluster species.
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| 10. |
- Moberg, Viktor, et al.
(author)
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Synthesis, characterization and reactivity of tetranuclear ruthenium hydrido clusters containing chiral phosphine ligands
- 2006
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In: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9234. ; :1, s. 279-288
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Journal article (peer-reviewed)abstract
- The chiral clusters [H4Ru4(CO)(12-n)(L)(n)] (n = 1, 2; L = NMDPP), 1,1-[H4Ru4(CO)(10)(L - L)] (L - L = DUPHOS, DIPAMP), 1,2-[H4Ru4(CO)(10)(DIOP)] and [{H4Ru4(CO)(10)(DIOP)}(2)] have been synthesized by derivatizing the parent carbonyl cluster [H4Ru4(CO)(12)] with the appropriate mono- or didentate chiral phosphine ligand. The phosphine-substituted clusters were found to be able to catalyze the ( asymmetric) hydrogenation of tiglic acid albeit with relatively low selectivity (enantiomeric excesses varying from 0 to 23%). It was found that the stability of the chiral ruthenium hydride clusters and the product distribution obtained in the catalytic reactions are dependent on the nature of the chiral phosphine. The crystal structures of [H4Ru4(CO)(12-n)(L)(n)] (n = 1, 2; L = NMDPP), 1,1-[H4Ru4(CO)(10)(L-L)] (L - L = DUPHOS, O-DUPHOS ( partially oxygenated ligand), DIPAMP), 1,2-[H4Ru4(CO)(10)(DIOP)] and [{H4Ru4(CO)(10)(DIOP)}(2)] are presented.
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