| 1. |
- Arnfred, Benjamin, et al.
(author)
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Group cognitive behavioural therapy with virtual reality exposure versus group cognitive behavioural therapy with in vivo exposure for social anxiety disorder and agoraphobia : a protocol for a randomised clinical trial
- 2022
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In: BMJ Open. - : BMJ Publishing Group. - 2044-6055. ; 12:2
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Journal article (peer-reviewed)abstract
- Introduction Anxiety disorders have a high lifetime prevalence, early-onset and long duration or chronicity. Exposure therapy is considered one of the most effective elements in cognitive behavioural therapy (CBT) for anxiety, but in vivo exposure can be challenging to access and control, and is sometimes rejected by patients because they consider it too aversive. Virtual reality allows flexible and controlled exposure to challenging situations in an immersive and protected environment. Aim The SoREAL-trial aims to investigate the effect of group cognitive behavioural therapy (CBT-in vivo) versus group CBT with virtual reality exposure (CBT-in virtuo) for patients diagnosed with social anxiety disorder and/or agoraphobia, in mixed groups. Methods and analysis The design is an investigator-initiated randomised, assessor-blinded, parallel-group and superiority-designed clinical trial. Three hundred two patients diagnosed with social anxiety disorder and/or agoraphobia will be included from the regional mental health centres of Copenhagen and North Sealand and the Northern Region of Denmark. All patients will be offered a manual-based 14-week cognitive behavioural group treatment programme, including eight sessions with exposure therapy. Therapy groups will be centrally randomised with concealed allocation sequence to either CBT-in virtuo or CBT-in vivo. Patients will be assessed at baseline, post-treatment and 1-year follow-up by treatment blinded researchers and research assistants. The primary outcome will be diagnosis-specific symptoms measured with the Liebowitz Social Anxiety Scale for patients with social anxiety disorder and the Mobility Inventory for Agoraphobia for patients with agoraphobia. Secondary outcome measures will include depression symptoms, social functioning and patient satisfaction. Exploratory outcomes will be substance and alcohol use, working alliance and quality of life. Ethics and dissemination The trial has been approved by the research ethics committee in the Capital Region of Denmark. All results, positive, negative as well as inconclusive, will be published as quickly as possible and still in concordance with Danish law on the protection of confidentially and personal information. Results will be presented at national and international scientific conferences. The trial has obtained approval by the Regional Ethics Committee of Zealand (H-6-2013-015) and the Danish Data Protection Agency (RHP-2014-009-02670). The trial is registered at ClinicalTrial.gov as NCT03845101. The patients will receive information on the trial both verbally and in written form. Written informed consent will be obtained from each patient before inclusion in the trial. The consent form will be scanned and stored in the database system and the physical copy will be destroyed. It is emphasised that participation in the trial is voluntary and that the patient can withdraw his or her consent at any time without consequences for further and continued treatment.
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| 2. |
- Duenser, Benno, et al.
(author)
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Attitudes towards plants - exploring the role of plants' ecosystem services
- 2024
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In: Journal of Biological Education. - : Routledge. - 0021-9266 .- 2157-6009.
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Journal article (peer-reviewed)abstract
- With biodiversity loss as one of today's most pressing global problems, it is crucial to raise public recognition of this crisis and promote acceptance of conservation efforts. Plants, which typically struggle with low awareness ('plant blindness') and less emotional connection than animals with humans, are facing a special challenge. Promoting positive attitudes towards, and interest in, plants might provide the key to resolve this discrepancy. This study aims to differentiate attitudes and interest within the plant awareness framework while at the same time identify criteria for developing positive attitudes and interest towards plants in students. In a mixed-method approach, a questionnaire with closed and open items on attitudes and interest was developed and administered online to 179 students aged 9-19. Quantitative as well as qualitative results show that 'attitudes towards plants' can be differentiated from 'interest in plants'. Attitudes towards plants were positive, whereas interest in plants was rather low, with cultural and regulating ecosystem services acting as primary reasons for students' positive attitudes. These two components can be easily incorporated in botany teaching in order to promote plant awareness and increase knowledge about their crucial role in ecosystems and global climate, thus raising acceptance for conservation.
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| 3. |
- Oudin, Anna, et al.
(author)
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Impact of national holidays and weekends on incidence of acute type A aortic dissection repair
- 2022
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 12:1
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Journal article (peer-reviewed)abstract
- Previous studies have demonstrated that environmental and temporal factors may affect the incidence of acute type A aortic dissection (ATAAD). Here, we aimed to investigate the hypothesis that national holidays and weekends influence the incidence of surgery for ATAAD. For the period 1st of January 2005 until 31st of December 2019, we investigated a hypothesised effect of (country-specific) national holidays and weekends on the frequency of 2995 surgical repairs for ATAAD at 10 Nordic cities included in the Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD) collaboration. Compared to other days, the number of ATAAD repairs were 29% (RR 0.71; 95% CI 0.54–0.94) lower on national holidays and 26% (RR 0.74; 95% CI 0.68–0.82) lower on weekends. As day of week patterns of symptom duration were assessed and the primary analyses were adjusted for period of year, our findings suggest that the reduced surgical incidence on national holidays and weekends does not seem to correspond to seasonal effects or surgery being delayed and performed on regular working days.
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| 4. |
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| 5. |
- Albert, Damien, et al.
(author)
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A Decade with VAMDC : Results and Ambitions
- 2020
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In: Atoms. - : MDPI. - 2218-2004. ; 8:4
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Journal article (peer-reviewed)abstract
- This paper presents an overview of the current status of the Virtual Atomic and Molecular Data Centre (VAMDC) e-infrastructure, including the current status of the VAMDC-connected (or to be connected) databases, updates on the latest technological development within the infrastructure and a presentation of some application tools that make use of the VAMDC e-infrastructure. We analyse the past 10 years of VAMDC development and operation, and assess their impact both on the field of atomic and molecular (A&M) physics itself and on heterogeneous data management in international cooperation. The highly sophisticated VAMDC infrastructure and the related databases developed over this long term make them a perfect resource of sustainable data for future applications in many fields of research. However, we also discuss the current limitations that prevent VAMDC from becoming the main publishing platform and the main source of A&M data for user communities, and present possible solutions under investigation by the consortium. Several user application examples are presented, illustrating the benefits of VAMDC in current research applications, which often need the A&M data from more than one database. Finally, we present our vision for the future of VAMDC.
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| 6. |
- Bausch, Birke, et al.
(author)
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Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention
- 2017
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In: JAMA Oncology. - : AMER MEDICAL ASSOC. - 2374-2437 .- 2374-2445. ; 3:9, s. 1204-1212
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Journal article (peer-reviewed)abstract
- IMPORTANCE Effective cancer prevention is based on accurate molecular diagnosis and results of genetic family screening, genotype-informed risk assessment, and tailored strategies for early diagnosis. The expanding etiology for hereditary pheochromocytomas and paragangliomas has recently included SDHA, TMEM127, MAX, and SDHAF2 as susceptibility genes. Clinical management guidelines for patients with germline mutations in these 4 newly included genes are lacking. OBJECTIVE To study the clinical spectra and age-related penetrance of individuals with mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes. DESIGN, SETTING, AND PATIENTS This study analyzed the prospective, longitudinally followed up European-American-Asian Pheochromocytoma-Paraganglioma Registry for prevalence of SDHA, TMEM127, MAX, and SDHAF2 germline mutation carriers from 1993 to 2016. Genetic predictive testing and clinical investigation by imaging from neck to pelvis was offered to mutation-positive registrants and their relatives to clinically characterize the pheochromocytoma/paraganglioma diseases associated with mutations of the 4 new genes. MAIN OUTCOMES AND MEASURES Prevalence and spectra of germline mutations in the SDHA, TMEM127, MAX, and SDHAF2 genes were assessed. The clinical features of SDHA, TMEM127, MAX, and SDHAF2 disease were characterized. RESULTS Of 972 unrelated registrants without mutations in the classic pheochromocytoma- and paraganglioma-associated genes (632 female [65.0%] and 340 male [35.0%]; age range, 8-80; mean [SD] age, 41.0 [13.3] years), 58 (6.0%) carried germline mutations of interest, including 29 SDHA, 20 TMEM127, 8 MAX, and 1 SDHAF2. Fifty-three of 58 patients (91%) had familial, multiple, extra-adrenal, and/or malignant tumors and/or were younger than 40 years. Newly uncovered are 7 of 63 (11%) malignant pheochromocytomas and paragangliomas in SDHA and TMEM127 disease. SDHA disease occurred as early as 8 years of age. Extra-adrenal tumors occurred in 28 mutation carriers (48%) and in 23 of 29 SDHA mutation carriers (79%), particularly with head and neck paraganglioma. MAX disease occurred almost exclusively in the adrenal glands with frequently bilateral tumors. Penetrance in the largest subset, SDHA carriers, was 39% at 40 years of age and is statistically different in index patients (45%) vs mutation-carrying relatives (13%; P amp;lt; .001). CONCLUSIONS AND RELEVANCE The SDHA, TMEM127, MAX, and SDHAF2 genes may contribute to hereditary pheochromocytoma and paraganglioma. Genetic testing is recommended in patients at clinically high risk if the classic genes are mutation negative. Gene-specific prevention and/or early detection requires regular, systematic whole-body investigation.
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| 7. |
- Bengtsson, Ragnar, et al.
(author)
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Nuclear physics - A non-disappearing magic trick
- 2007
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 449:7161, s. 411-411
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Journal article (other academic/artistic)abstract
- Well-established models of nuclei describe properties such as shells and magic numbers. But how do these predictions stand up to scrutiny for exotic, unstable nuclei? Pretty well, according to the latest study.
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| 8. |
- de Vera, Jean-Pierre, et al.
(author)
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Limits of Life and the Habitability of Mars : The ESA Space Experiment BIOMEX on the ISS
- 2019
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In: Astrobiology. - : Mary Ann Liebert. - 1531-1074 .- 1557-8070. ; 19:2, s. 145-157
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Journal article (other academic/artistic)abstract
- BIOMEX (BIOlogy and Mars EXperiment) is an ESA/Roscosmos space exposure experiment housed within the exposure facility EXPOSE-R2 outside the Zvezda module on the International Space Station (ISS). The design of the multiuser facility supports-among others-the BIOMEX investigations into the stability and level of degradation of space-exposed biosignatures such as pigments, secondary metabolites, and cell surfaces in contact with a terrestrial and Mars analog mineral environment. In parallel, analysis on the viability of the investigated organisms has provided relevant data for evaluation of the habitability of Mars, for the limits of life, and for the likelihood of an interplanetary transfer of life (theory of lithopanspermia). In this project, lichens, archaea, bacteria, cyanobacteria, snow/permafrost algae, meristematic black fungi, and bryophytes from alpine and polar habitats were embedded, grown, and cultured on a mixture of martian and lunar regolith analogs or other terrestrial minerals. The organisms and regolith analogs and terrestrial mineral mixtures were then exposed to space and to simulated Mars-like conditions by way of the EXPOSE-R2 facility. In this special issue, we present the first set of data obtained in reference to our investigation into the habitability of Mars and limits of life. This project was initiated and implemented by the BIOMEX group, an international and interdisciplinary consortium of 30 institutes in 12 countries on 3 continents. Preflight tests for sample selection, results from ground-based simulation experiments, and the space experiments themselves are presented and include a complete overview of the scientific processes required for this space experiment and postflight analysis. The presented BIOMEX concept could be scaled up to future exposure experiments on the Moon and will serve as a pretest in low Earth orbit.
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| 9. |
- Ejbye-Ernst, Peter, et al.
(author)
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"It's illegal to buy drugs from street dealers" : a video-based pre-post study of a behavioral intervention to displace dealers from an Amsterdam open-air drug market
- 2023
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In: Journal of Experimental Criminology. - : Springer. - 1573-3750 .- 1572-8315.
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Journal article (peer-reviewed)abstract
- Objectives: A high number of street dealers operate in the Red Light District in Amsterdam, The Netherlands. To displace the dealers, the Municipality of Amsterdam installed text-based light projections in a street attracting a high number of dealers.Methods: To evaluate the intervention, we did a pre-post analysis of video footage from two CCTV cameras located in the street. In total, we analyzed 765 one-minute segments of footage from before and after the implementation.Results: The implementation was followed by a four percentage point reduction in street dealers. However, the estimated effect shows fragileness with wide confidence intervals and a p-value just below 0.05, and a Bayesian robustness analysis suggests that the intervention was not associated with the outcome.Conclusions: Analyzing CCTV-footage offers a unique avenue for evaluating small scale interventions in open-air drug markets. While we observed a decrease in the presence of dealers, the intervention still needs further validation.
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| 10. |
- Ejbye-Ernst, Peter, et al.
(author)
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“It’s illegal to buy drugs from the street dealers” : A Video-Based Study of a Behavioral Intervention to Reduce Dealers in Amsterdam
- 2023
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Conference paper (other academic/artistic)abstract
- A high number of street dealers operate in the open-air drug market in the Red Light District in Amsterdam, The Netherlands selling cocaine and ecstasy to visitors. This is a nuisance to shop owners and inhabitants in the area. To mitigate this problem, the Municipality of Amsterdam installed three text-based light projections on the pavement and walls of a specific street known for attracting high numbers of dealers. The text discouraged visitors from buying drugs from street dealers. The aim of the intervention was to displace dealers from the specific street to surrounding areas. In order to investigate the influence of this intervention, we collected and analyzed video footage from two CCTV cameras located in the street. We analyzed a total of 765 one-minute segments of video footage from before and after the intervention was implemented. The analysis of the video footage showed that there were statistically significantly fewer street dealers observed in the street after the intervention was implemented. This difference amounted to an approximately 25 percent reduction of observed street dealers, when we controlled for time of day, day of the week, and the crowding of the area. These results indicate that the light-based interventions successfully discouraged street dealers from operating in the street. This influence of the intervention might be connected to the nature of the Open-Air Drug market in the Red Light District, which is almost exclusively catering to tourists and where dealers are constantly moving around rather than standing still. The generalizability of the current study to other open-air drug markets therefore remains uncertain.
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