| 1. |
- Mukherjee, Subhankar, et al.
(author)
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Sensory development for heavy metal detection: A review on translation from conventional analysis to field-portable sensor
- 2021
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In: Trends in Food Science & Technology. - : ELSEVIER SCIENCE LONDON. - 0924-2244 .- 1879-3053. ; 109, s. 674-689
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Research review (peer-reviewed)abstract
- Background: In recent decades, contaminations with heavy metals ions have adversely affected the environment, food safety, and human health. Heavy metals, leaching to water sources from the industrial effluents, can enter into the aquatic and food chains of humans and animals from a variety of anthmpogenic sources. Scope and Approach: Heavy metal detection has been an intensive area of research today. Both laboratory-based analytical instruments and innovative sensor devices like the electronic nose, electronic tongue, and bio/ chemical sensors have increasingly emerged to meet the demand for legislative actions on environmental pollution control and early warning. These evolving technology and developments particularly in the area of nanotechnology and sensors have become key contributing factors in heavy metal detection. Key Findings and Conclusions: This endeavor aims at exploring this field in detail to understand the key principles behind this flourishing science and summarize the recent development in heavy metal detection technologies. This article also gives a brief review of commercially available portable devices that has the potential to become the next gold standard instruments in heavy metal detection.
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| 2. |
- Naseri, Maryam, et al.
(author)
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A multivalent aptamer-based electrochemical biosensor for biomarker detection in urinary tract infection
- 2021
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In: Electrochimica Acta. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0013-4686 .- 1873-3859. ; 389
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Journal article (peer-reviewed)abstract
- Lactoferrin is a multifunctional protein of the transferrin family and is known as a biomarker for various clinical diseases including urinary tract infection (UTI). However, wide concentration range of lactoferrin in urine samples due to the high interpatient variations, requires a more practical biosensor. In this article, we used a novel multivalent aptamer immobilized on the surface of screen-printed gold electrode (aptamer/SPGE) to develop the first electrochemical aptasensor for label-free detection of lactoferrin with wide dynamic detection range and high sensitivity. The performance of the fabricated biosensor was tested using electrochemical impedance spectroscopy and differential pulse voltammetry. The multivalent aptamer as the bioreceptor with high affinity and good specificity against human lactoferrin, acts to enhance the electrochemical signals and widen the working window. The aptamer/SPGE demonstrates superior sensing performances for lactoferrin in buffer solution, with a wide linear range of 10 to 1300 ng/mL with LOD of 0.9 ng/mL, as well as high selectivity, and excellent reproducibility. Besides, the constructed aptasensor was successfully applied to quantify lactoferrin concentrations in spiked urine solutions. Owing to excellent sensitivity, ease of miniaturization, simple sensing procedure, low-cost, and fast response, the proposed electrochemical aptasensor indicates a great potential towards the development of lactoferrin analysis systems, which would be helpful in the early diagnosis of UTI. (C) 2021 Elsevier Ltd. All rights reserved.
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| 3. |
- Zhao, Changhong, 1982, et al.
(author)
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Synthesis of graphene quantum dots and their applications in drug delivery
- 2020
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In: Journal of Nanobiotechnology. - : Springer Science and Business Media LLC. - 1477-3155. ; 18:1
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Research review (peer-reviewed)abstract
- This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]
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