| 1. |
- Byström, JW, et al.
(author)
-
Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions
- 2022
-
In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
-
Journal article (other academic/artistic)abstract
- The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture is usually performed by trained staff at health care centers. Long travel distances may introduce a bias of testing towards relatively large communities with close access to health care centers. Rural regions may thus be overlooked. Here, we demonstrate a sensitive method to measure antibodies to the S-protein of SARS-CoV-2. We adapted and optimized this assay for clinical use together with capillary blood sampling to meet the geographical challenges of serosurveillance. Finally, we tested remote at-home capillary blood sampling together with centralized assessment of S-specific IgG in a rural region of northern Scandinavia that encompasses 55,185 sq kilometers. We conclude that serological assessment from capillary blood sampling gives comparable results as analysis of venous blood. Importantly, at-home sampling enabled citizens living in remote rural areas access to centralized and sensitive laboratory antibody tests.
|
|
| 2. |
- Bianchi, M., et al.
(author)
-
One-dimensional spin texture of Bi(441): Quantum spin Hall properties without a topological insulator
- 2015
-
In: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 91:16
-
Journal article (peer-reviewed)abstract
- The high index (441) surface of bismuth has been studied using scanning tunneling microscopy (STM), angle resolved photoemission spectroscopy (APRES), and spin-resolved ARPES. The surface is strongly corrugated, exposing a regular array of (110)-like terraces. Two surface localized states are observed, both of which are linearly dispersing in one in-plane direction (k(x)), and dispersionless in the orthogonal in-plane direction (k(y)), and both of which have a Dirac-like crossing at k(x) = 0. Spin ARPES reveals a strong in-plane polarization, consistent with Rashba-like spin-orbit coupling. One state has a strong out-of-plane spin component, which matches with the miscut angle, suggesting its possible origin as an edge state. The electronic structure of Bi(441) has significant similarities with topological insulator surface states and is expected to support one-dimensional quantum spin Hall-like coupled spin-charge transport properties with inhibited backscattering, without requiring a topological insulator bulk.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Collins, M D, et al.
(author)
-
Characterization of Actinomyces isolates from infected root canals of teeth: description of Actinomyces radicidentis sp. nov.
- 2000
-
In: Journal of clinical microbiology. - 0095-1137. ; 38:9, s. 3399-403
-
Journal article (peer-reviewed)abstract
- Two strains of a previously undescribed Actinomyces-like bacterium were recovered in pure culture from infected root canals of teeth. Analysis by biochemical testing and polyacrylamide gel electrophoresis of whole-cell proteins indicated that the strains closely resembled each other phenotypically but were distinct from previously described Actinomyces and Arcanobacterium species. Comparative 16S rRNA gene-sequencing studies showed the bacterium to be a hitherto unknown subline within a group of Actinomyces species which includes Actinomyces bovis, the type species of the genus. Based on phylogenetic and phenotypic evidence, we propose that the unknown bacterium isolated from human clinical specimens be classified as Actinomyces radicidentis sp. nov. The type strain of Actinomyces radicidentis is CCUG 36733.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Niemiec, Maria Joanna, et al.
(author)
-
Augmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection
- 2022
-
In: Frontiers in Cellular and Infection Microbiology. - : Frontiers Media S.A.. - 2235-2988. ; 12
-
Journal article (peer-reviewed)abstract
- The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast Candida albicans and the Gram-negative bacterium Proteus mirabilis resulting in enhanced host cell damage. This synergistic effect was conserved across different P. mirabilis isolates and occurred also with non-albicans Candida species and C. albicans mutants defective in filamentation or candidalysin production. Using bacterial deletion mutants, we identified the P. mirabilis hemolysin HpmA to be the key effector for host cell destruction. Spatially separated coinfections demonstrated that synergism between Candida and Proteus is induced by contact, but also by soluble factors. Specifically, we identified Candida-mediated glucose consumption and farnesol production as potential triggers for Proteus virulence. In summary, our study demonstrates that coinfection of enterocytes with C. albicans and P. mirabilis can result in increased host cell damage which is mediated by bacterial virulence factors as a result of fungal niche modification via nutrient consumption and production of soluble factors. This supports the notion that certain fungal-bacterial combinations have the potential to result in enhanced virulence in niches such as the gut and might therefore promote translocation and dissemination.
|
|
| 9. |
|
|
| 10. |
- Song, F., et al.
(author)
-
Extracting the near surface stoichiometry of BiFe0.5Mn0.5O3 thin films; a finite element maximum entropy approach
- 2012
-
In: Surface Science. - : Elsevier BV. - 0039-6028. ; 606:23-24, s. 1771-1776
-
Journal article (peer-reviewed)abstract
- The surface and near-surface chemical composition of BiFe0.5Mn0.5O3 has been studied using a combination of low photon energy synchrotron photoemission spectroscopy, and a newly developed maximum entropy finite element model from which it is possible to extract the depth dependent chemical composition. In the uppermost few unit cells, an overabundance of Bi, and a deficiency of Fe and Mn are observed. In deeper layers, the measurements are consistent with bulk-like stoichiometry. Additionally, a definitive identification of all the observed species together with their abundance and depth dependence is given, and the mixed Fe and Mn valencies are estimated. In addition to the expected bulk valencies Mn3+ and Fe3+, some Fe2+ and a small amount of Mn4+ are also observed. The maximum entropy finite element model demonstrated here is also discussed in more general terms and its potential application to the broader field of perovskite thin films is made apparent. (C) 2012 Elsevier B.V. All rights reserved.
|
|
