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  • Nadadhur, A. G., et al. (author)
  • Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells
  • 2017
  • In: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 12:6
  • Journal article (peer-reviewed)abstract
    • Generation of neuronal cultures from induced pluripotent stem cells (hiPSCs) serve the studies of human brain disorders. However we lack neuronal networks with balanced excitatory- inhibitory activities, which are suitable for single cell analysis. We generated low-density networks of hPSC-derived GABAergic and glutamatergic cortical neurons. We used two different co-culture models with astrocytes. We show that these cultures have balanced excitatory-inhibitory synaptic identities using confocal microscopy, electrophysiological recordings, calcium imaging and mRNA analysis. These simple and robust protocols offer the opportunity for single-cell to multi-level analysis of patient hiPSC-derived cortical excitatory- inhibitory networks; thereby creating advanced tools to study disease mechanisms underlying neurodevelopmental disorders.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Meijer, M (1)
Verhage, M (1)
Hjorth, Johannes (1)
Jacobs, G (1)
Smit, A. B. (1)
Schut, D (1)
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Toonen, R. F. (1)
Nadadhur, A. G. (1)
Melero, J. E. (1)
Wan Li, K. (1)
Meredith, R. M. (1)
Van Kesteren, R. E. (1)
Heine, V. M. (1)
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University
Royal Institute of Technology (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2017 (1)

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