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Träfflista för sökning "WFRF:(Nagler A) "

Search: WFRF:(Nagler A)

  • Result 1-10 of 110
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  • 2019
  • Journal article (peer-reviewed)
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  • Crawley, C, et al. (author)
  • Outcomes of reduced-intensity transplantation for chronic myeloid leukemia : an analysis of prognóstic factors from the Chronic Leukemia Working Party of the EBMT
  • 2005
  • In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 106:9, s. 2969-2976
  • Journal article (peer-reviewed)abstract
    • This study reports outcomes of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning (RIC) in 186 patients with chronic myeloid leukemia (CML) from the European Group for Blood and Marrow Transplantation (EBMT). The median age was 50 years, and 64% were in first chronic phase (CP1), CP2 13%, accelerated phase 17%, and blast crises 6%. The median EBMT transplant score was 3. The day 100 transplantation-related mortality (TRM) was 6.1% (confidence interval [CI], 3.4%-11%) but rose to 23.3% (CI, 14%-27%) at 2 years. Fludarabine, busulfan, and antithymocyte globulin (Fd/Bu/ATG) was associated with the lowest TRM of 11.6% (CI, 4.7%-11%) at 1 year. Acute graft-versus-host disease (GvHD) grade II to IV occurred in 32% and chronic GvHD in 43% (extensive in 24%). ATG was associated with a lower incidence of chronic GvHD (cGvHD). The overall survival (OS) and progression-free survival (PFS) at 3 years were 58% (CI, 50%-66%) and 37% (CI, 30%-45%), respectively. Adverse OS was associated with advanced disease (relative risk [RR], 3.4). PFS was inferior in advanced disease (RR, 2.7) and a trend to improved outcomes with Fd/Bu/ATG (RR, 0.58). RIC allografts are feasible in CML in first or second CP. Since no other RIC regimen demonstrated superiority, Fd/Bu/ATG should be considered as baseline in future prospective trials.
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  • Crawley, C, et al. (author)
  • Outcomes for reduced-intensity allogeneic transplantation for multiple myeloma: an analysis of prognostic factors from the Chronic Leukaemia Working Party of the EBMT
  • 2005
  • In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 105:11, s. 4532-4539
  • Journal article (peer-reviewed)abstract
    • We report the outcome of 229 patients who received an allograft for myeloma with reduced-intensity conditioning (RIC) regimens from 33 centers within the European Group for Blood and Marrow Transplantation (EBMT). The median age was 52 years and 64% were male. Conditioning regimens were heterogeneous, but most were fludarabine based and T cell depleted with antithymocyte globulin or alemtuzumab. Transplantation-related mortality (TRIM) at 1 year was 22%. The 3-year overall survival (OS) and progression-free survival (PFS) were 41% and 21 %, respectively. Adverse OS was associated with chemoresistant disease (relative risk [RR], 2.9), more than 1 prior transplantation (RR, 2.0), and male patients with female donors (FIR, 1.45). Adverse PFS was associated with chemoresistance (RR, 2.4) and alemtuzumab (RR, 1.8). TRM was increased with female-to-male donation (RR, 2.5) and transplantation more than 1 year from diagnosis (RR, 2.3). Grades II to IV acute graft-versus-host disease (aGvHD) occurred in 31%. Chronic GvHD was associated with better OS and PFS and were 84% and 46% for limited, 58% and 30% for extensive, and 29% and 12% in its absence suggesting that a graft-versus-myeloma effect is important. While RIC is feasible, heavily pretreated patients and patients with progressive disease do not benefit.
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  • Result 1-10 of 110
Type of publication
journal article (86)
conference paper (24)
Type of content
peer-reviewed (89)
other academic/artistic (21)
Author/Editor
Nagler, A (87)
Mohty, M (59)
Labopin, M (47)
Socie, G (31)
Kroger, N (30)
Mielke, S (28)
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Ljungman, P (28)
Ciceri, F (27)
Blaise, D. (24)
Finke, J. (23)
Yakoub-Agha, I (23)
Niederwieser, D (19)
Giebel, S (19)
Ringden, O (18)
Maertens, J (15)
Chevallier, P. (14)
Rambaldi, A (13)
Schmid, C. (11)
Snowden, JA (11)
Craddock, C. (11)
Cornelissen, JJ (11)
Gedde-Dahl, T. (10)
Volin, L (10)
Styczynski, J (10)
Dreger, P (9)
Gratwohl, A (9)
Savani, B (9)
Kuball, J (9)
Sureda, A (9)
Bonini, C (8)
Saccardi, R (8)
Nagler, B. (8)
Rocha, V (8)
Basak, GW (8)
Spyridonidis, A (8)
Forcade, E (8)
Brecht, A (8)
Ehninger, G (8)
Sadeghi, B (7)
Kersten, MJ (7)
Aljurf, M (7)
Michallet, M (7)
Tridello, G (7)
Baron, F (7)
Ruggeri, A (7)
Stelljes, M (7)
Huynh, A (7)
Sierra, J (7)
Brissot, E (7)
Savani, BN (7)
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University
Karolinska Institutet (85)
Uppsala University (9)
Linköping University (7)
Lund University (6)
Chalmers University of Technology (5)
Royal Institute of Technology (3)
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Umeå University (2)
Mid Sweden University (2)
University of Gothenburg (1)
Halmstad University (1)
Stockholm University (1)
Karlstad University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (110)
Research subject (UKÄ/SCB)
Natural sciences (14)
Medical and Health Sciences (8)
Social Sciences (1)

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