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Search: WFRF:(Nah C.)

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  • Carmona-Gutierrez, D, et al. (author)
  • The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species
  • 2019
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 651-
  • Journal article (peer-reviewed)abstract
    • Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia. Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice. This pro-autophagic response induces a conserved systemic change in metabolism, operates independently of TORC1 signalling and depends on specific GATA transcription factors. Notably, we identify DMC in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine. In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug.
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5.
  • Raghavan, P., et al. (author)
  • Electrochemical characterization of poly(vinylidene fluoride-co-hexafluoro propylene) based electrospun gel polymer electrolytes incorporating moth temperature ionic liquids as green electrolytes for lithium batteries
  • 2014
  • In: Solid State Ionics. - : Elsevier BV. - 0167-2738. ; 262, s. 77-82
  • Journal article (peer-reviewed)abstract
    • A series of gel polymer electrolytes (GPEs) based on electrospun membranes of poly(vinylidene fluoride-co-hexafluoropropylene) [P(VdF-co-HFP)] incorporating room temperature ionic liquids (RTILs), 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide complexed with lithium bis(trifluoromethylsulfonyl) inside (LiTFSI) as electrolytes have been prepared and their fundamental electrochemical properties were investigated. The morphology of electrospun membranes was examined by a field emission scanning electron microscope (FE-SEM). The membranes show uniform morphology with an average fiber diameter of 780 nm, high porosity and high electrolyte uptake. GPEs were prepared by soaking the electrospun membranes in 1 M LiTFSI in RTILs for 1 h and exhibit a high ionic conductivity of 2.4 x 10(-3)-4.5 x 10(-3) S cm(-1) at 25 degrees C. A Li/GPEs/LiFePO4 cell using these RTILs delivers high discharge capacity (similar to 140 mAh g(-1)) when evaluated at 25 degrees C at 0.1 C-rate and exhibits a very stable discharge capacity under continuous cycling. Among the GPEs, EMITFSI shows the highest electrochemical properties although the solid electrolyte interface (SEI) layer was not formed.
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