| 1. |
- Stadskleiv, K., et al.
(author)
-
Aided communication, mind understanding and co-construction of meaning
- 2022
-
In: Developmental Neurorehabilitation. - : Informa UK Limited. - 1751-8423 .- 1751-8431. ; 25:8, s. 518-530
-
Journal article (peer-reviewed)abstract
- Mind understanding allows for the adaptation of expressive language to a listener and is a core element when communicating new information to a communication partner. There is limited knowledge about the relationship between aided language and mind understanding. This study investigates this relationship using a communication task. The participants were 71 aided communicators using graphic symbols or spelling for expression (38/33 girls/boys) and a reference group of 40 speaking children (21/19 girls/boys), aged 5;0-15;11 years. The task was to describe, but not name, drawings to a communication partner. The partner could not see the drawing and had to infer what was depicted from the child's explanation. Dyads with aided communicators solved fewer items than reference dyads (64% vs 93%). The aided spellers presented more precise details than the symbol users (46% vs 38%). In the aided group, number of correct items correlated with verbal comprehension and age.
|
|
| 2. |
- Auranen, K., et al.
(author)
-
Prompt and delayed spectroscopy of At-203 : Observation of a shears band and a 29/2(+) isomeric state
- 2018
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 97:2
-
Journal article (peer-reviewed)abstract
- Using fusion-evaporation reactions, a gas-filled recoil separator, recoil-gating technique and recoil-isomer decay tagging technique we have extended the level scheme of At-203 (N = 118) significantly. We have observed an isomeric [tau = 14.1(3) mu s] state with a spin and parity of 29/2(+). The isomeric state is suggested to originate from the pi(h(9/2)) circle times |Po-202; 11(-)> coupling, and it is depopulated through 286 keV E2 and 366 keV E3 transitions. In addition, we have observed a cascade of magnetic-dipole transitions which is suggested to be generated by the shears mechanism.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Itkonen, Matti K., et al.
(author)
-
Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans
- 2018
-
In: Clinical Pharmacology and Therapeutics. - : Wiley. - 0009-9236 .- 1532-6535. ; 104:3, s. 495-504
-
Journal article (peer-reviewed)abstract
- The oxidation of montelukast is mainly mediated by cytochrome P450 (CYP) 2C8, but other mechanisms may contribute to its disposition. In healthy volunteers, we investigated the effects of two widely used P2Y(12) inhibitors on montelukast pharmacokinetics. Clopidogrel (300mg on day 1 and 75mg on day 2) increased the area under the plasma concentration-time curve (AUC) of montelukast 2.0-fold (90% confidence interval (CI) 1.72-2.28, P < 0.001) and decreased the M6:montelukast AUC(0-7h) ratio to 45% of control (90% CI 40-50%, P < 0.001). Prasugrel (60mg on day 1 and 10mg on day 2) had no clinically meaningful effect on montelukast pharmacokinetics. Our results imply that clopidogrel is at least a moderate inhibitor of CYP2C8, but prasugrel is not a clinically relevant CYP2C8 inhibitor. The different interaction potentials of clopidogrel and prasugrel are important to consider when antiplatelet therapy is planned for patients at risk for polypharmacy with CYP2C8 substrates.
|
|
| 7. |
|
|
| 8. |
- Auranen, K., et al.
(author)
-
Experimental study of isomeric intruder 1/2(+) states in At-197,At-203
- 2017
-
In: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 95:4
-
Journal article (peer-reviewed)abstract
- A newly observed isomeric intruder 1/2(+) state [T-1/2 = 3.5( 6) ms] is identified in At-203 using a gas-filled recoil separator and fusion-evaporation reactions. The isomer is depopulated through a cascade of E3 and mixed M1/E2 transitions to the 9/2(-) ground state, and it is suggested to originate from the pi(s(1/2))(-1) configuration. In addition, the structures above the 1/2(+) state in At-203 and At-197 are studied using in-beam gamma-ray spectroscopy, recoil-decay tagging, and recoil-isomer decay tagging methods. The 1/2(+) state is fed from 3/2(+) and 5/2(+) states, and the origin of these states are discussed.
|
|
| 9. |
- de Huu, M., et al.
(author)
-
Design of gravimetric primary standards for field-testing of hydrogen refuelling stations
- 2020
-
In: Flow Measurement and Instrumentation. - : Elsevier Ltd. - 0955-5986 .- 1873-6998. ; 73
-
Journal article (peer-reviewed)abstract
- The Federal Institute of Metrology METAS developed a Hydrogen Field Test Standard (HFTS) that can be used for field verification and calibration of hydrogen refuelling stations. The testing method is based on the gravimetric principle. The experimental design of the HFTS as well as the description of the method are presented here. The HFTS has been tested at METAS with nitrogen gas at −40 °C to mimic a refuelling process in the field. Laboratory tests have shown that icing on the pipes of the HFTS have a non-negligible impact on the results. Field-testing with the HFTS has also been performed at the Empa hydrogen refuelling station with hydrogen at up to 70 MPa. The major uncertainty components have been identified and assigned values. The required expanded uncertainty of 0.3% could be achieved. A detailed uncertainty budget has been presented and shows that the scale is the largest contributor; buoyancy corrections only play a minor role. For the lowest uncertainty measurements, appropriate waiting times or cleaning methods to get rid of icing are required. © 2020 The Authors
|
|
| 10. |
- Gromov, K., et al.
(author)
-
Varying but reduced use of postoperative mobilization restrictions after primary total hip arthroplasty in Nordic countries: a questionnaire-based study
- 2019
-
In: Acta Orthopaedica. - : Medical Journals Sweden AB. - 1745-3674 .- 1745-3682. ; 90:2, s. 143-147
-
Journal article (peer-reviewed)abstract
- Background and purpose Mobilization has traditionally been restricted following total hip arthroplasty (THA) in an attempt to reduce the risk of dislocation and muscle detachment. However, recent studies have questioned the effect and rationale underlying such restrictions. We investigated the use of postoperative restrictions and possible differences in mobilization protocols following primary THA in Denmark (DK), Finland (FIN), Norway (NO), and Sweden (SWE).Patients and methods All hospitals performing primary THA in the participating countries were identified from the latest national THA registry report. A questionnaire containing questions regarding standard surgical procedure, use of restrictions, and postoperative mobilization protocol was distributed to all hospitals through national representatives for each arthroplasty registry.Results 83% to 94% (n = 167) of the 199 hospitals performing THA in DK, FIN, NO, and SWE returned correctly filled out questionnaires. A posterolateral approach was used by 77% of the hospitals. 92% of the hospitals had a standardized mobilization protocol. 50%, 41%, 19%, and 38% of the hospitals in DK, FIN, NO, and SWE, respectively, did not have any postoperative restrictions. If utilized, restrictions were applied for a median of 6 weeks. Two-thirds of all hospitals have changed their mobilization protocol within the last 5 yearsall but 2 to a less restrictive protocol.Interpretation Use of postoperative restrictions following primary THA differs between the Nordic countries, with 19% to 50% allowing mobilization without any restrictions. There has been a strong tendency towards less restrictive mobilization over the last 5 years.
|
|
