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1.	Abbafati, Cristiana, et al. (author) 2020 Journal article (peer-reviewed)
2.	Halvorsen, Cecilia Pegelow, et al. (author) A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care 2019 In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9 Journal article (peer-reviewed)abstract There is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-inresult- out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson's correlation test was 0.91 (p < 0.01) and the R-2 = 0.83 between the two methods. The mean LDH (+/- SD) for the reference method vs. the POC-LDH was 551 (+/- 280) U/L and 552 (+/- 249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Johansson, Lars (1); Sulo, Gerhard (1); Hassankhani, Hadi (1); Liu, Yang (1); Ali, Muhammad (1); Mitchell, Philip B (1); show more...; McKee, Martin (1); Madotto, Fabiana (1); Abolhassani, Hassan (1); Rezaei, Nima (1); Castro, Franz (1); Koul, Parvaiz A. (1); Weiss, Daniel J. (1); Ackerman, Ilana N. (1); Brenner, Hermann (1); Ferrara, Giannina (1); Salama, Joseph S. (1); Mullany, Erin C. (1); Abbafati, Cristiana (1); Bensenor, Isabela M. (1); Bernabe, Eduardo (1); Carrero, Juan J. (1); Cercy, Kelly M. (1); Zaki, Maysaa El Saye ... (1); Esteghamati, Alireza (1); Esteghamati, Sadaf (1); Fanzo, Jessica (1); Farzadfar, Farshad (1); Foigt, Nataliya A. (1); Grosso, Giuseppe (1); Islami, Farhad (1); James, Spencer L. (1); Khader, Yousef Saleh (1); Kimokoti, Ruth W. (1); Kumar, G. Anil (1); Lallukka, Tea (1); Lotufo, Paulo A. (1); Mendoza, Walter (1); Nagel, Gabriele (1); Nguyen, Cuong Tat (1); Nixon, Molly R. (1); Ong, Kanyin L. (1); Pereira, David M. (1); Rivera, Juan A. (1); Sanchez-Pimienta, Ta ... (1); Shin, Min-Jeong (1); Thrift, Amanda G. (1); Tran, Bach Xuan (1); Uthman, Olalekan A. (1); Vasankari, Tommi Juh ... (1); show less...

University: Uppsala University (2); Karolinska Institutet (2); Royal Institute of Technology (1); Högskolan Dalarna (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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