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- Uhlén, Mathias, et al.
(author)
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The human secretome
- 2019
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In: Science Signaling. - : American Association for the Advancement of Science (AAAS). - 1945-0877 .- 1937-9145. ; 12:609
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Journal article (peer-reviewed)abstract
- The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we present a comprehensive analysis of proteins predicted to be secreted in human cells, which provides information about their final localization in the human body, including the proteins actively secreted to peripheral blood. The analysis suggests that a large number of the proteins of the secretome are not secreted out of the cell, but instead are retained intracellularly, whereas another large group of proteins were identified that are predicted to be retained locally at the tissue of expression and not secreted into the blood. Proteins detected in the human blood by mass spectrometry-based proteomics and antibody-based immuno-assays are also presented with estimates of their concentrations in the blood. The results are presented in an updated version 19 of the Human Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access knowledge resource of the human secretome, including body-wide expression data, spatial localization data down to the single-cell and subcellular levels, and data about the presence of proteins that are detectable in the blood.
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- Heimdal Nilsson, Elna, et al.
(author)
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Tropospheric Photolysis Rates of the Acetaldehyde Isotopologues CD3CHO and CD3CDO Relative to CH3CHO Measured at the European Photoreactor Facility.
- 2015
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In: The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory. - : American Chemical Society (ACS). - 1520-5215. ; 119:11, s. 2562-2567
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Journal article (peer-reviewed)abstract
- Acetaldehyde is a hazardous pollutant found in indoor and ambient air. Acetaldehyde photolysis is pressure- and wavelength-dependent with three distinct product channels. In this study, the photolysis rates of CH3CHO, CD3CDO, and CD3CHO are studied in natural tropospheric conditions using long path FTIR spectroscopy, at the European Photoreactor Facility (EUPHORE) in Valencia, Spain. The average relative photolysis rate as an average of four experiments for the fully deuterated isotopologue is jCH3CHO/jCD3CDO = 1.75 ± 0.04, and as a result of a single experiment jCH3CHO/jCD3CHO = 1.10 ± 0.10. These results, combined with our previous determination of jCH3CHO/jCH3CDO = 1.26 ± 0.03, provide mechanistic insight into the photodissociation dynamics of the photoexcited species. Despite the extensive isotopic scrambling in photoexcited acetaldehyde that has recently been reported, the position of the substitution has a clear effect on the relative photolysis rates.
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- Popovski, Petar, et al.
(author)
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Wireless Access for Ultra-Reliable Low-Latency Communication (URLLC): Principles and Building Blocks
- 2018
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In: IEEE Network. - 1558-156X .- 0890-8044. ; 32:2, s. 16-23
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Journal article (peer-reviewed)abstract
- Ultra-reliable low latency communication (URLLC) is an important new feature brought by 5G, with a potential to support a vast set of applications that rely on mission-critical links. In this article, we first discuss the principles for supporting URLLC from the perspective of the traditional assumptions and models applied in communication/information theory. We then discuss how these principles are applied in various elements of the system design, such as use of various diversity sources, design of packets and access protocols. The important messages are that there is a need to optimize the transmission of signaling information, as well as a need for a lean use of various sources of diversity.
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