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1.	Scirica, BM, et al. (author) Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus 2013 In: The New England journal of medicine. - 1533-4406. ; 369:14, s. 1317-1326 Journal article (peer-reviewed)
2.	Georgakis, MK, et al. (author) Central nervous system tumours among adolescents and young adults (15-39 years) in Southern and Eastern Europe: Registration improvements reveal higher incidence rates compared to the US 2017 In: European journal of cancer (Oxford, England : 1990). - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 86, s. 46-58 Journal article (peer-reviewed)
3.	Georgakis, MK, et al. (author) Perinatal and early life risk factors for childhood brain tumors: Is instrument-assisted delivery associated with higher risk? 2019 In: Cancer epidemiology. - : Elsevier BV. - 1877-783X .- 1877-7821. ; 59, s. 178-184 Journal article (peer-reviewed)
4.	Karalexi, MA, et al. (author) Birth seasonality of childhood central nervous system tumors: Analysis of primary data from 16 Southern-Eastern European population-based registries 2020 In: International journal of cancer. - : Wiley. - 1097-0215 .- 0020-7136. ; 147:5, s. 1252-1263 Journal article (peer-reviewed)
5.	Pateras, Ioannis S., et al. (author) Diagnostic challenges during inflammation and cancer : current biomarkers and future perspectives in navigating through the minefield of reactive versus dysplastic and cancerous lesions in the digestive system 2024 In: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 25:2 Research review (peer-reviewed)abstract In the setting of pronounced inflammation, changes in the epithelium may overlap with neoplasia, often rendering it impossible to establish a diagnosis with certainty in daily clinical practice. Here, we discuss the underlying molecular mechanisms driving tissue response during persistent inflammatory signaling along with the potential association with cancer in the gastrointestinal tract, pancreas, extrahepatic bile ducts, and liver. We highlight the histopathological challenges encountered in the diagnosis of chronic inflammation in routine practice and pinpoint tissue-based biomarkers that could complement morphology to differentiate reactive from dysplastic or cancerous lesions. We refer to the advantages and limitations of existing biomarkers employing immunohistochemistry and point to promising new markers, including the generation of novel antibodies targeting mutant proteins, miRNAs, and array assays. Advancements in experimental models, including mouse and 3D models, have improved our understanding of tissue response. The integration of digital pathology along with artificial intelligence may also complement routine visual inspections. Navigating through tissue responses in various chronic inflammatory contexts will help us develop novel and reliable biomarkers that will improve diagnostic decisions and ultimately patient treatment.

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Type of publication: journal article (4); research review (1)

Type of content: peer-reviewed (5)

Author/Editor: Bastos, J. (2); Sekerija, M (2); Tragiannidis, A (2); Brown, J. (1); Li, Y. (1); Price, D. (1); show more...; Walder, J. (1); Wang, J. (1); Lu, J. (1); Nilsson, J. (1); Albert, M (1); Fischer, H. (1); Conway, J. (1); Moore, R. (1); Jain, S. (1); Robinson, S. (1); Bose, S. (1); Gupta, R. (1); Ma, R. (1); Das, D. (1); Gupta, V. (1); Schneider, R. (1); Horton, K. (1); Wood, J. (1); Hoffman, E. (1); Dellborg, M (1); Bao, Y. (1); Diaz, M. (1); Taylor, R. (1); Weiss, R. (1); Svensson, M. (1); Feldman, R (1); Shah, S (1); Xu, W (1); Chen, J. (1); Rosado, J. (1); Thomas, J. (1); Wood, K. (1); McGill, J (1); Sharma, V. (1); Pearce, M. (1); Osborne, J. (1); Jiang, M. (1); Mehta, P. (1); Anderson, J. (1); Medina, F (1); Lai, W. (1); Zhao, W. (1); Wu, W. (1); Olsson, A (1); show less...

University: Karolinska Institutet (5); Umeå University (1)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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