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- Noorian-Bidgoli, Majid
(author)
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Strength and deformability of fractured rocks
- 2014
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Doctoral thesis (other academic/artistic)abstract
- This thesis presents a systematic numerical modeling framework to simulate the stress-deformation and coupled stress-deformation-flow processes by performing uniaxial and biaxial compressive tests on fractured rock models with considering the effects of different loading conditions, different loading directions (anisotropy), and coupled hydro-mechanical processes for evaluating strength and deformability behavior of fractured rocks. By using code UDEC of discrete element method (DEM), a series of numerical experiments were conducted on discrete fracture network models (DFN) at an established representative elementary volume (REV), based on realistic geometrical and mechanical data of fracture systems from field mapping at Sellafield, UK. The results were used to estimate the equivalent Young’s modulus and Poisson’s ratio and to fit the Mohr-Coulomb and Hoek-Brown failure criteria, represented by equivalent material properties defining these two criteria.The results demonstrate that strength and deformation parameters of fractured rocks are dependent on confining pressures, loading directions, water pressure, and mechanical and hydraulic boundary conditions. Fractured rocks behave nonlinearly, represented by their elasto-plastic behavior with a strain hardening trend. Fluid flow analysis in fractured rocks under hydro-mechanical loading conditions show an important impact of water pressure on the strength and deformability parameters of fractured rocks, due to the effective stress phenomenon, but the values of stress and strength reduction may or may not equal to the magnitude of water pressure, due to the influence of fracture system complexity. Stochastic analysis indicates that the strength and deformation properties of fractured rocks have ranges of values instead of fixed values, hence such analyses should be considered especially in cases where there is significant scatter in the rock and fracture parameters. These scientific achievements can improve our understanding of fractured rocks’ hydro-mechanical behavior and are useful for the design of large-scale in-situ experiments with large volumes of fractured rocks, considering coupled stress-deformation-flow processes in engineering practice.
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- Tavakol, M, et al.
(author)
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Diagnostic Approach to the Patients with Suspected Primary Immunodeficiency
- 2020
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In: Endocrine, metabolic & immune disorders drug targets. - : Bentham Science Publishers Ltd.. - 2212-3873 .- 1871-5303. ; 20:2, s. 157-171
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Journal article (peer-reviewed)abstract
- Primary immunodeficiency diseases (PIDs) are a group of more than 350 disorders affecting distinct components of the innate and adaptive immune systems. In this review, the classic and advanced stepwise approach towards the diagnosis of PIDs are simplified and explained in detail.Results:Susceptibility to recurrent infections is the main hallmark of almost all PIDs. However, noninfectious complications attributable to immune dysregulation presenting with lymphoproliferative and/or autoimmune disorders are not uncommon. Moreover, PIDs could be associated with misleading presentations including allergic manifestations, enteropathies, and malignancies.Conclusion:Timely diagnosis is the most essential element in improving outcome and reducing the morbidity and mortality in PIDs. This wouldn’t be possible unless the physicians keep the diagnosis of PID in mind and be sufficiently aware of the approach to these patients.
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