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1.	Boddington, C, et al. (author) Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials 2019 In: Lancet (London, England). - 1474-547X. ; 393:10179, s. 1440-1452 Journal article (peer-reviewed)
2.	Wang, Anqi, et al. (author) Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants 2023 In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074 Journal article (peer-reviewed)abstract The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
3.	Bergh, J, et al. (author) Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials 2021 In: The Lancet. Oncology. - 1474-5488. ; 22:8, s. 1139-1150 Journal article (peer-reviewed)
4.	Altheimer, A., et al. (author) Boosted objects and jet substructure at the LHC. Report of BOOST2012, held at IFIC Valencia, 23rd-27th of July 2012 2014 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 74:3 Journal article (peer-reviewed)abstract This report of the BOOST2012 workshop presents the results of four working groups that studied key aspects of jet substructure. We discuss the potential of first-principle QCD calculations to yield a precise description of the substructure of jets and study the accuracy of state-of-the-art Monte Carlo tools. Limitations of the experiments' ability to resolve substructure are evaluated, with a focus on the impact of additional (pile-up) proton proton collisions on jet substructure performance in future LHC operating scenarios. A final section summarizes the lessons learnt from jet substructure analyses in searches for new physics in the production of boosted top quarks.
5.	Geisler, C. H., et al. (author) Nordic MCL2 Trial of 1St-Line Intensive Immunochemotherapy and Autologous Stem Cell Transplantation in Mantle Cell Lymphoma: Still Encouraging Results After Median 5½ Years Observation Time 2011 In: Biology of Blood and Marrow Transplantation. - : Elsevier BV. - 1083-8791. ; 17:2, s. 196-196 Conference paper (peer-reviewed)
6.	Matejcic, M, et al. (author) Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 382- Journal article (peer-reviewed)abstract The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
7.	Ostergaard, M, et al. (author) An Investigator-initiated Multicenter Randomized Study in Early Rheumatoid Arthritis of Active Conventional Therapy versus Three Biological Treatments: 48 Week Clinical and Radiographic Results of the NORD-STAR Trial 2021 In: ARTHRITIS & RHEUMATOLOGY. - 2326-5191. ; 73, s. 1701-1705 Conference paper (other academic/artistic)
8.	Chatzidionysiou, K, et al. (author) Smoking and Response to Rituximab in Anti-CCP Positive and Negative Rheumatoid Arthritis - Results from an International European Collaboration. 2014 In: ARTHRITIS & RHEUMATOLOGY. - 2326-5191. ; 66, s. S1104-S1104 Conference paper (other academic/artistic)
9.	Chatzidionysiou, K, et al. (author) SMOKING AND RESPONSE TO RITUXIMAB IN ANTI-CCP POSITIVE AND NEGATIVE RHEUMATOID ARTHRITIS - RESULTS FROM AN INTERNATIONAL EUROPEAN COLLABORATION 2015 In: ANNALS OF THE RHEUMATIC DISEASES. - : BMJ. - 0003-4967 .- 1468-2060. ; 74, s. 484-485 Conference paper (other academic/artistic)
10.	Dadaev, T, et al. (author) Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants 2018 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 2256- Journal article (peer-reviewed)abstract Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

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Result 1-10 of 157

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Type of publication: journal article (96); conference paper (58); other publication (1); research review (1); book chapter (1)

Type of content: peer-reviewed (84); other academic/artistic (73)

Author/Editor: Nordstrom, D (40); Hetland, ML (32); Tomsic, M. (31); Chatzidionysiou, K (30); Gudbjornsson, B (30); Pavelka, K (30); show more...; Lie, E (29); Nordstrom, T (27); Lukina, G (24); Askling, J (23); Gabay, C (23); Kvien, TK (22); Canhao, H (20); Ancuta, I (20); Glintborg, B (18); van Vollenhoven, R (16); di Giuseppe, D (16); Tarp, U (16); van Vollenhoven, RF (15); Ostergaard, M. (15); Grondal, G (14); Nordstrom, DC (14); Gomez-Reino, J (13); Nordstrom, L (13); Michelsen, B (13); Nasonov, E (13); Rotar, Z. (12); Hetland, M. L. (12); Kristianslund, E (12); Dreyer, L. (11); Gronberg, H (11); Aaltonen, K (11); Lantz, A (10); Iannone, F. (10); Hetland, M (10); Carrieri, G (10); Aly, M (9); Codreanu, C. (9); Jambor, I (9); Kvien, T (9); Cormio, L. (9); Eklund, M (8); Jacobsson, Lennart T ... (8); van Riel, P (8); Geirsson, AJ (8); Wiberg-Itzel, E (8); Lampa, J (7); Lindstrom, U (7); Uhlig, T. (7); Provan, S. A. (7); show less...

University: Karolinska Institutet (144); University of Gothenburg (16); Uppsala University (15); Lund University (10); Royal Institute of Technology (2); Umeå University (1); show more...; Linköping University (1); Chalmers University of Technology (1); IVL Swedish Environmental Research Institute (1); show less...

Language: English (157)

Research subject (UKÄ/SCB): Medical and Health Sciences (25); Natural sciences (3)

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