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1.	2019 Journal article (peer-reviewed)
2.	Arnison, Paul G., et al. (author) Ribosomally synthesized and post-translationally modified peptide natural products : overview and recommendations for a universal nomenclature 2013 In: Natural product reports (Print). - : Royal Society of Chemistry (RSC). - 0265-0568 .- 1460-4752. ; 30:1, s. 108-160 Research review (peer-reviewed)abstract This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
3.	Kalkunte, Satyan S., et al. (author) Transthyretin Is Dysregulated in Preeclampsia, and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model 2013 In: American Journal of Pathology. - : ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA. - 0002-9440 .- 1525-2191. ; 183:5, s. 1425-1436 Journal article (peer-reviewed)abstract Preeclampsia is a major pregnancy complication with potential short- and long-term consequences for both mother and fetus. Understanding its pathogenesis and causative biomarkers is likely to yield insights for prediction and treatment. Herein, we provide evidence that transthyretin, a transporter of thyroxine and retinal, is aggregated in preeclampsia and is present at reduced levels in sera of preeclamptic women, as detected by proteomic screen. We demonstrate that transthyretin aggregates form deposits in preeclampsia placental tissue and cause apoptosis. By using in vitro approaches and a humanized mouse model, we provide evidence for a causal link between dysregulated transthyretin and preeclampsia. Native transthyretin inhibits all preeclampsia-like features in the humanized mouse model, including new-onset proteinuria, increased blood pressure, glomerular endotheliosis, and production of anti-angiogenic factors. Our findings suggest that a focus on transthyretin structure and function is a novel strategy to understand and combat preeclampsia.

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Type of publication: journal article (2); research review (1)

Type of content: peer-reviewed (3)

Author/Editor: Kelly, Daniel (1); Bengtsson-Palme, Joh ... (1); Nilsson, Henrik (1); Kelly, Ryan (1); Li, Ying (1); Moore, Matthew D. (1); show more...; Markert, Udo R. (1); Sharma, Surendra (1); Liu, Fang (1); Zhang, Yao (1); Jin, Yi (1); Raza, Ali (1); Rafiq, Muhammad (1); Zhang, Kai (1); Khatlani, T (1); Kahan, Thomas (1); Göransson, Ulf (1); Craik, David J. (1); Sörelius, Karl, 1981 ... (1); Batra, Jyotsna (1); Roobol, Monique J (1); Backman, Lars (1); Yan, Hong (1); Schmidt, Axel (1); Lorkowski, Stefan (1); Thrift, Amanda G. (1); Zhang, Wei (1); Hammerschmidt, Sven (1); Patil, Chandrashekha ... (1); Wang, Jun (1); Pollesello, Piero (1); Conesa, Ana (1); El-Esawi, Mohamed A. (1); Olofsson, Anders (1); Zhang, Weijia (1); Li, Jian (1); Marinello, Francesco (1); Frilander, Mikko J. (1); Wei, Pan (1); Badie, Christophe (1); Zhao, Jing (1); Li, You (1); Bansal, Abhisheka (1); Rahman, Proton (1); Parchi, Piero (1); Polz, Martin (1); Ijzerman, Adriaan P. (1); Subhash, Santhilal, ... (1); Quinn, Terence J. (1); Uversky, Vladimir N. (1); show less...

University: Uppsala University (2); University of Gothenburg (1); Umeå University (1); Halmstad University (1); Stockholm University (1); Linköping University (1); show more...; Lund University (1); Chalmers University of Technology (1); Karolinska Institutet (1); show less...

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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