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1.	Brautigam, Lars, et al. (author) Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1 2013 In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 110:50, s. 20057-20062 Journal article (peer-reviewed)abstract Embryonic development depends on complex and precisely orchestrated signaling pathways including specific reduction/oxidation cascades. Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational modifications of protein thiols. The importance of this protein family during embryogenesis has recently been exemplified for glutaredoxin 2, a vertebrate-specific glutathione-disulfide oxidoreductase with a critical role for embryonic brain development. Here, we discovered an essential function of glutaredoxin 2 during vascular development. Confocal microscopy and time-lapse studies based on two-photon microscopy revealed that morpholino-based knockdown of glutaredoxin 2 in zebrafish, a model organism to study vertebrate embryogenesis, resulted in a delayed and disordered blood vessel network. We were able to show that formation of a functional vascular system requires glutaredoxin 2-dependent reversible S-glutathionylation of the NAD(+)-dependent protein deacetylase sirtuin 1. Using mass spectrometry, we identified a cysteine residue in the conserved catalytic region of sirtuin 1 as target for glutaredoxin 2-specific deglutathionylation. Thereby, glutaredoxin 2-mediated redox regulation controls enzymatic activity of sirtuin 1, a mechanism we found to be conserved between zebrafish and humans. These results link S-glutathionylation to vertebrate development and successful embryonic angiogenesis.
2.	Gaengel, Konstantin, et al. (author) The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2 2013 In: Angiogenesis. - 0969-6970 .- 1573-7209. ; 16:1, s. 246-247 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Uhlen, Per (2); Nystrom, Staffan (2); Ebarasi, Lwaki (1); Jakobsson, Lars (1); Majumdar, Arindam (1); Holmgren, Arne (1); show more...; Cao, Yihai (1); Adams, Ralf (1); Betsholtz, Christer (1); Gaengel, Konstantin (1); Niaudet, Colin (1); Dreij, Kristian (1); Vestweber, Dietmar (1); Benedito, Rui (1); Hellstrom, Mats (1); Berndt, Carsten (1); Bannenberg, Sarah (1); Brautigam, Lars (1); Dahl Ejby Jensen, La ... (1); Poschmann, Gereon (1); Lepka, Klaudia (1); Prozorovski, Timour (1); Montano, Sergio J (1); Aktas, Orhan (1); Stuehler, Kai (1); Roswall, Pernilla (1); Yi, Jin (1); Larsson, Jimmy (1); Fuxe, Jonas (1); Hagikura, Kazuhiro (1); Siemsen, Lavina Barb ... (1); Muhl, Lar (1); Hofmann, J. Jennifer (1); Rymo, Simin (1); Long, Chen Long (1); Mei-Fong, Pang (1); Raschperger, Elisabe ... (1); Schulte, Doerte (1); Uv, Anne (1); show less...

University: Karolinska Institutet (2); Uppsala University (1); Linköping University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2013 (2)

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