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- Juliusson, Gunnar, et al.
(author)
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The prognostic impact of FLT3-ITD and NPM1 mutation in adult AML is age-dependent in the population-based setting
- 2020
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In: Blood Advances. - : AMER SOC HEMATOLOGY. - 2473-9529 .- 2473-9537. ; 4:6, s. 1094-1101
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Journal article (peer-reviewed)abstract
- In acute myeloid leukemia (AML) FLT3 internal tandem duplication (ITD) and nucleophosmin 1 (NPM1) mutations provide prognostic information with clinical relevance through choice of treatment, but the effect of age and sex on these molecular markers has not been evaluated. The Swedish AML Registry contains data on FLT3-ITD and NPM1 mutations dating to 2007, and 1570 adult patients younger than 75 years, excluding acute promyelocytic leukemia, had molecular results reported. Females more often had FLT3(ITD) and/or NPM1(mut) (FLT3(ITD) : female, 29%; male, 22% [P - .00151; NPM1(mut) : female, 36%; male, 27% [P < .0001]), and more males were double negative (female, 53%; male, 64%; P < .0001). Patients with FLT3(ITD) were younger than those without (59 vs 62 years; P = .023), in contrast to patients with NPM1(mut) (62 vs 60 years; P = .059). Interestingly, their prognostic effect had a strong dependence on age: FLT3(ITD) indicated poor survival in younger patients (<60 years; P = .00003), but had no effect in older patients (60-74 years; P = .5), whereas NPM1(mut) indicated better survival in older patients (P = .00002), but not in younger patients (P = .95). In FLT3(ITD)/NPM1(mut) patients, the survival was less dependent on age than in the other molecular subsets. These findings are likely to have clinical relevance for risk grouping, study design, and choice of therapy.
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- Nilsson, Christer, et al.
(author)
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Characterization of therapy-related acute myeloid leukemia : increasing incidence and prognostic implications
- 2023
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In: Haematologica. - : Ferrata Storti Foundation. - 0390-6078 .- 1592-8721. ; 108:4, s. 1015-1025
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Journal article (peer-reviewed)abstract
- Studies of therapy-related AML (t-AML) are usually performed in selected cohorts and reliable incidence rates are lacking. In this study, we characterized, defined the incidence over time and studied prognostic implications in all t-AML patients diagnosed in Sweden between 1997 and 2015. Data were retrieved from nationwide population-based registries. In total, 6,779 AML patients were included in the study, of whom 686 (10%) had t-AML. The median age for t-AML was 71 years and 392 (57%) patients were females. During the study period, the incidence of t-AML almost doubled with a yearly increase in t-AML of 4.5% (95% confidence interval: 2.8%-6.2%), which contributed significantly to the general increase in AML incidence over the study period. t-AML solidly constituted over 10% of all AML cases during the later period of the study. Primary diagnoses with the largest increase in incidence and decrease in mortality rate during the study period (i.e., breast and prostate cancer) contributed significantly to the increased incidence of t-AML. In multivariable analysis, t-AML was associated with poorer outcome in cytogenetically intermediate-and adverse-risk cases but t-AML had no significant impact on outcome in favorable-risk AML, including core binding leukemias, acute promyelocytic leukemia and AML with mutated NPM1 without FLT3-ITD. We conclude that there is a strong increase in incidence in t-AML over time and that t-AML constitutes a successively larger proportion of the AML cases. Furthermore, we conclude that t-AML confers a poor prognosis in cytogenetically intermediate-and adverse-risk, but not in favorable-risk AML.
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- Olander, Elin, et al.
(author)
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Stakeholder’ perception of product messages
- 2007
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Other publication (other academic/artistic)abstract
- Designers create messages that are encoded in the products’ design and consumers perceive the products in an environment. Hence the product can be seen as a communication media between the designer and different product stakeholders. The stakeholder’s response to the designer’s intent embodied in the product design falls into three categories: cognitive, affective and behavioural. In some cases, it is important to have an understanding of stakeholder response to product design. This paper presents theories, approaches and methods for the understanding of stakeholder response to designer intent embodied in product design and discusses them in relation to the extent to which they are usable in a design project. The possible use and appropriateness of the theories and methods are exemplified by the authors’ ongoing research projects. Since the perception of a product form is subjective, there can be differences between designers’ and stakeholders’ responses to product design. Therefore, in some cases, it is important to make designer intent and stakeholder response explicit and to analyse the discrepancies. Using different approaches and methods to understand stakeholder response can be used to improve a product design and for guiding the stakeholders’ choices of products to purchase.
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