| 1. |
- Anderson, Helén, et al.
(author)
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Skapa kundnärvaro i innovationsprocessen
- 2008
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In: Innovationsförmåga. - Malmö : Holmbergs i Malmö AB. - 9789197785204 ; , s. 40-59
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Book chapter (pop. science, debate, etc.)
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| 2. |
- Ballantyne, Kaye N., et al.
(author)
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Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
- 2014
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In: Human Mutation. - : John Wiley & Sons. - 1059-7794 .- 1098-1004. ; 35:8, s. 1021-1032
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Journal article (peer-reviewed)abstract
- Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, greater than99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database.
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| 3. |
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| 4. |
- Bengtsson, Kenneth, et al.
(author)
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Så kan Sverige bli ledande nation i resurseffektivitet
- 2016
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In: Dagens Nyheter. - 1101-2447. ; :2016-04-30
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Journal article (pop. science, debate, etc.)abstract
- Ny rapport. Det svenska näringslivet kan bli mer hållbart, resurssmart och därmed internationellt konkurrenskraftigt. Men för det behövs en tydlig politisk avsiktsförklaring och riktlinjer. Vi har listat sex områden där policyutveckling brådskar, skriver företrädare för näringsliv, forskning och myndigheter i en gemensam uppmaning.
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| 5. |
- Björklund, Camilla, et al.
(author)
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Matematikkundervisning
- 2013
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Book (other academic/artistic)abstract
- Denna boken är skriven av en grupp erfarna norska och svenska lärarutbildare i matematik. Boken bygger på utprövad erfarenhet - såväl egen som andras - och på aktuell, relevant forskning i matematikdidaktik. Texten väver samman matematik och matematikdidaktik, det vill säga ämnet som det undervisas i och frågor om hur ämnet kan läras och undervisas. Boken innehåller det som är absolut viktigast att få med sig i den grundläggande lärarutbildningen i matmatik.
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| 6. |
- Eriksson, Gunilla, et al.
(author)
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Same island, different diet : Cultural evolution of food practice on Öland, Sweden, from the Mesolithic to the Roman Period
- 2008
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In: Journal of Anthropological Archaeology. - : Elsevier BV. - 0278-4165 .- 1090-2686. ; 27:4, s. 520-543
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Journal article (peer-reviewed)abstract
- The Mesolithic–Neolithic transition in north-west Europe has been described as rapid and uniform, entailing a swift shift from the use of marine and other wild resources to domesticated terrestrial resources. Here, we approach the when, what and how of this transition on a regional level, using empirical data from Öland, an island in the Baltic Sea off the Swedish east coast, and also monitor changes that occurred after the shift. Radiocarbon dating and stable carbon and nitrogen isotope analyses of bones and teeth from 123 human individuals, along with faunal isotope data from 27 species, applying to nine sites on Öland and covering a time span from the Mesolithic to the Roman Period, demonstrate a great diversity in food practices, mainly governed by culture and independent of climatic changes. There was a marked dietary shift during the second half of the third millennium from a mixed marine diet to the use of exclusively terrestrial resources, interpreted as marking the large-scale introduction of farming. Contrary to previous claims, this took place at the end of the Neolithic and not at the onset. Our data also show that culturally induced dietary transitions occurred continuously throughout prehistory. The availability of high-resolution data on various levels, from intra-individual to inter-population, makes stable isotope analysis a powerful tool for studying the evolution of food practices.
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| 7. |
- Fischer, Marie, 1970-
(author)
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Mast cells in Hodgkin lymphoma : or 'What's a nice cell like you doing in a tumour like this?'
- 2004
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Doctoral thesis (other academic/artistic)abstract
- Mast cell (MC) accumulation around tumours is an old observation gaining new relevance due to the multifaceted nature of MCs and their many roles in immunity, beyond allergy. Knowledge about tumour specific recruitment of, and interactions with, MCs is needed to unravel the function of their presence.This study investigates the participation of mast cells in the tumourigenesis of Hodgkin lymphoma (HL), a tumour with many inflammatory features. We report that MC recruitment into HL lymphomatous tissue is possibly due to the production of CCL5/RANTES by malignant Hodgkin and Reed-Sternberg (HRS) cells. In addition, increased levels of IL-9, a cytokine implicated in mast cell heterogeneity and as an autocrine growth factor for HRS cells, were found in HL patient sera and correlate with negative prognostic factors. The ubiquitous expression of CD30 by HRS cells has been implicated in HL tumour development. In HL tissue MCs were found to be the predominant CD30 ligand (CD30L) expressing cells, and through CD30L/CD30 engagement they induced a proliferative response in HRS cells. This interaction proved to be bi-directional as it induced a degranulation-independent de novo synthesis of a specific set of chemokines in MCs, including IL-8. This novel trigger of MC activation is suggested to be of importance also in atopic dermatitis (AD) and psoriasis since increased numbers of CD30L and IL-8 positive MCs were detected along with increased expression of CD30.Data presented in this study supports a specific recruitment of MCs into HL tumours and co-operative interactions between HRS cells and MCs. Our identification of reversed signalling via CD30L as a novel MC trigger provides a mechanism behind leukocyte infiltration and chronic development in diseases associated with CD30 and MCs, such as HL, AD and psoriasis.
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| 8. |
- Forsberg, Lars A., et al.
(author)
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Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
- 2015
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In: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 25:10, s. 1521-1535
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Journal article (peer-reviewed)abstract
- Sporadic breast cancer (SBC) is a common disease without robust means of early risk prediction in the population. We studied 282 females with SBC, focusing on copy number aberrations in cancer-free breast tissue (uninvolved margin, UM) outside the primary tumor (PT). In total, 1162 UMs (1-14 per breast) were studied. Comparative analysis between UM(s), PT(s), and blood/skin from the same patient as a control is the core of the study design. We identified 108 patients with at least one aberrant UM, representing 38.3% of cases. Gains in gene copy number were the principal type of mutations in microscopically normal breast cells, suggesting that oncogenic activation of genes via increased gene copy number is a predominant mechanism for initiation of SBC pathogenesis. The gain of ERBB2, with overexpression of HER2 protein, was the most common aberration in normal cells. Five additional growth factor receptor genes (EGFR, FGFR1, IGF1R, LIFR, and NGFR) also showed recurrent gains, and these were occasionally present in combination with the gain of ERBB2. All the aberrations found in the normal breast cells were previously described in cancer literature, suggesting their causative, driving role in pathogenesis of SBC. We demonstrate that analysis of normal cells from cancer patients leads to identification of signatures that may increase risk of SBC and our results could influence the choice of surgical intervention to remove all predisposing cells. Early detection of copy number gains suggesting a predisposition toward cancer development, long before detectable tumors are formed, is a key to the anticipated shift into a preventive paradigm of personalized medicine for breast cancer.
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| 9. |
- Grevholm, Barbro, et al.
(author)
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Lära och undervisa matematik : från förskoleklass till åk 6
- 2012
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Book (other academic/artistic)abstract
- Lära och undervisa matematik - från förskoleklass till åk 6 är en grundbok i matematik och matematikämnets didaktik. Den vänder sig till lärarstuderande och till verksamma lärare som vill aktualisera sina kunskaper och ta del av den senaste forskningen samt sätta sig in i de nya kursplanerna och kunskapskraven i matematik.
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| 10. |
- Gu, Xiaohong
(author)
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Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models
- 2023
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Doctoral thesis (other academic/artistic)abstract
- Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). We utilized the GAL4-UAS system to express human proIAPP (hproIAPP), human IAPP (hIAPP) and mouse IAPP (mIAPP) in the brain of Drosophila melanogaster. In transmission electron microscope (TEM), we observed an accumulation of non-fibrillar aggregates in fat body tissue surrounding the brain. TEM tomography used for ultrastructure analysis revealed a spherical shape and a 5-fold twinning structure composed of two crystal packings: the body centered tetragonal (BCT) structure and the triclinic structure.Our biological systems have developed the ability to assist in folding and removing non-functional proteins. We directed the expression of hproIAPP and hIAPP to the 16 ventral lateral neurons (LNvs) and monitored intracellular responses to protein aggregation. We observed that overexpression of hproIAPP and hIAPP significantly reduced the number of LNvs over time. Further studies showed that expression of hproIAPP and hIAPP did not trigger ER stress and apoptosis but resulted in an accumulation of ubiquitinated aggregates, autophagosomes, and lysosomes, indicative of activation of aggrephagy. Overexpression of hproIAPP/hIAPP in flies with the Gstd-ROS reporter results in ROS generation, which can contribute to cell death. Systemic amyloidosis is a rare condition where amyloid deposits occur in multiple organ systems. Deposits of wild type transthyretin (TTRwt) cause the most prevalent form of systemic amyloidosis, while TTR mutations can result in familial forms of the disease. The clinical profile in hereditary ATTR amyloidosis differs in the age of onset, tissue distribution, symptoms, disease penetrance, and prognosis. The Gal4-UAS system was applied to produce flies expressing human TTRwt and single mutant TTR. The Hand-C-Gal4 driver directs the TTR expression in the cardioblasts of the heart. We found the expression of TTRV30L, TTRV30M, TTRA109S, and TTRL111M had a significant impact on cardiac parameters. The Nrv2-Gal4 driver directs the TTR expression to the central and peripheral nerve cells. Expression of TTRV30L, TTRV30M, TTRL55P, and TTR L111M by Nrv2-Gal4 altered the activity or circadian rhythm in the fly. The results showed that different mutations give rise to different phenotypes. In summary, our Drosophila melanogaster models provide valuable insights into amyloidosis and allow for cellular and organ analysis.
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