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- Sharma, N, et al.
(author)
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RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury
- 2021
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In: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 22:17
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Journal article (peer-reviewed)abstract
- The regulator of G protein signaling (RGS) represents a widespread system of controllers of cellular responses. The activities of the R4 subfamily of RGSs have been elucidated in allergic pulmonary diseases. However, the R4 signaling in other inflammatory lung diseases, with a strong cellular immune response, remained unexplored. Thus, our study aimed to discern the functional relevance of the R4 family member, RGS5, as a potential modulating element in this context. Gene profiling of the R4 subfamily showed increased RGS5 expression in human fibrosing lung disease samples. In line with this, RGS5 was markedly increased in murine lungs following bleomycin injury. RGS knock-out mice (RGS-/-) had preserved lung function while control mice showed significant combined ventilatory disorders three days after bleomycin application as compared to untreated control mice. Loss of RGS5 was associated with a significantly reduced neutrophil influx and tissue myeloperoxidase expression. In the LPS lung injury model, RGS5-/- mice also failed to recruit neutrophils into the lung, which was accompanied by reduced tissue myeloperoxidase levels after 24 h. Our in-vitro assays showed impaired migration of RGS5-/- neutrophils towards chemokines despite preserved Ca2+ signaling. ERK dephosphorylation might play a role in reduced neutrophil migration in our model. As a conclusion, loss of RGS5 preserves lung function and attenuates hyperinflammation in the acute phase of bleomycin-induced pulmonary fibrosis and LPS-induced lung injury. Targeting RGS5 might alleviate the severity of exacerbations in interstitial lung diseases.
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- Sandström, Camilla, Professor, 1967-, et al.
(author)
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Mainstreaming biodiversity and nature's contributions to people in Europe and Central Asia: insights from IPBES to inform the CBD post-2020 agenda
- 2023
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In: Ecosystems and People. - : Informa UK Limited. - 2639-5908 .- 2639-5916. ; 19:1
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Journal article (peer-reviewed)abstract
- Recent global and regional assessments of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) show that Nature's Contributions to People (NCP) are under an alarming threat due to the continuing loss of biodiversity. These assessments call for increasing conservation efforts and a more sustainable use of biodiversity to enhance the chances of halting biodiversity loss and reversing current trends. One of the strategies to achieve change is to mainstream biodiversity into sectoral policies. Mainstreaming, a concept that can be traced back to the Brundtland report, promotes the integration of the environment into political, societal, and economic planning and decision-making. Based on the review of key studies undertaken during the regional assessment for Europe and Central Asia, we develop a stepwise approach to analyze the current status of mainstreaming of biodiversity and NCP. The approach can be used both for policy design purposes and diagnostic evaluations. It demonstrates that mainstreaming has the potential to improve the conservation and sustainable use of biodiversity as well as the sustained provision of NCP. However, based on the status of implementation across Europe and Central Asia, we conclude that mainstreaming needs to be pursued and implemented in a stronger and more systematic way. The results of our assessment provide important input to national strategies and policies but also to the ongoing process of the Conference of the Parties to the Convention on Biological Diversity while developing the post-2020 global biodiversity framework.
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- Ring, Irene, et al.
(author)
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Chapter 6: Options for governance and decision-making across scales and sectors
- 2018
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In: IPBES. - Bonn : Secretariat of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem services. - 9783947851089 ; , s. 661-802
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Book chapter (other academic/artistic)abstract
- Within the generic scope of the Regional Assessments of Biodiversity and Ecosystem Services, the key policy‑relevant questions of the Europe and Central Asia Assessment concern options and opportunities with regard to biodiversity and ecosystem services and their role for human well-being. The assessment examines the opportunities for sectoral policies and policy instruments; managing production, consumption and economic development; and ecological infrastructures and ecological technologies. It explores opportunities to promote food security, economic development and equality while avoiding land and aquatic degradation and conserving cultural landscapes.
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