| 1. |
- AghaKouchak, Amir, et al.
(author)
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Anthropogenic Drought : Definition, Challenges, and Opportunities
- 2021
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In: Reviews of geophysics. - : John Wiley & Sons. - 8755-1209 .- 1944-9208. ; 59:2
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Research review (peer-reviewed)abstract
- Traditional, mainstream definitions of drought describe it as deficit in water-related variables or water-dependent activities (e.g., precipitation, soil moisture, surface and groundwater storage, and irrigation) due to natural variabilities that are out of the control of local decision-makers. Here, we argue that within coupled human-water systems, drought must be defined and understood as a process as opposed to a product to help better frame and describe the complex and interrelated dynamics of both natural and human-induced changes that define anthropogenic drought as a compound multidimensional and multiscale phenomenon, governed by the combination of natural water variability, climate change, human decisions and activities, and altered micro-climate conditions due to changes in land and water management. This definition considers the full spectrum of dynamic feedbacks and processes (e.g., land-atmosphere interactions and water and energy balance) within human-nature systems that drive the development of anthropogenic drought. This process magnifies the water supply demand gap and can lead to water bankruptcy, which will become more rampant around the globe in the coming decades due to continuously growing water demands under compounding effects of climate change and global environmental degradation. This challenge has de facto implications for both short-term and long-term water resources planning and management, water governance, and policymaking. Herein, after a brief overview of the anthropogenic drought concept and its examples, we discuss existing research gaps and opportunities for better understanding, modeling, and management of this phenomenon.
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| 2. |
- Alborzi, Aneseh, et al.
(author)
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Climate-informed environmental inflows to revive a drying lake facing meteorological and anthropogenic droughts
- 2018
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In: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 13:8
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Journal article (peer-reviewed)abstract
- The rapid shrinkage of Lake Urmia, one of the world's largest saline lakes located in northwestern Iran, is a tragic wake-up call to revisit the principles of water resources management based on the socio-economic and environmental dimensions of sustainable development. The overarching goal of this paper is to set a framework for deriving dynamic, climate-informed environmental inflows for drying lakes considering both meteorological/climatic and anthropogenic conditions. We report on the compounding effects of meteorological drought and unsustainable water resource management that contributed to Lake Urmia's contemporary environmental catastrophe. Using rich datasets of hydrologic attributes, water demands and withdrawals, as well as water management infrastructure (i.e. reservoir capacity and operating policies), we provide a quantitative assessment of the basin's water resources, demonstrating that Lake Urmia reached a tipping point in the early 2000s. The lake level failed to rebound to its designated ecological threshold (1274 m above sea level) during a relatively normal hydro-period immediately after the drought of record (1998-2002). The collapse was caused by a marked overshoot of the basin's hydrologic capacity due to growing anthropogenic drought in the face of extreme climatological stressors. We offer a dynamic environmental inflow plan for different climate conditions (dry, wet and near normal), combined with three representative water withdrawal scenarios. Assuming effective implementation of the proposed 40% reduction in the current water withdrawals, the required environmental inflows range from 2900 million cubic meters per year (mcm yr(-1)) during dry conditions to 5400 mcm yr(-1) during wet periods with the average being 4100 mcm yr(-1). Finally, for different environmental inflow scenarios, we estimate the expected recovery time for re-establishing the ecological level of Lake Urmia.
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| 3. |
- Ashraf, Samaneh, et al.
(author)
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Compounding effects of human activities and climatic changes on surface water availability in Iran
- 2019
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In: Climatic Change. - : Springer Science and Business Media LLC. - 0165-0009 .- 1573-1480. ; 152:3-4, s. 379-391
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Journal article (peer-reviewed)abstract
- By combining long-term ground-based data on water withdrawal with climate model projections, this study quantifies the compounding effects of human activities and climate change on surface water availability in Iran over the twenty-first century. Our findings show that increasing water withdrawal in Iran, due to population growth and increased agricultural activities, has been the main source of historical water stress. Increased levels of water stress across Iran are expected to continue or even worsen over the next decades due to projected variability and change in precipitation combined with heightened water withdrawals due to increasing population and socio-economic activities. The greatest rate of decreased water storage is expected in the Urmia Basin, northwest of Iran, (varying from -8.3mm/year in 2010-2039 to -61.6mm/year in 2070-2099 compared with an observed rate of 4mm/year in 1976-2005). Human activities, however, strongly dominate the effects of precipitation variability and change. Major shifts toward sustainable land and water management are needed to reduce the impacts of water scarcity in the future, particularly in Iran's heavily stressed basins like Urmia Basin, which feeds the shrinking Lake Urmia.
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| 4. |
- Azadpour, Behnam, et al.
(author)
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Magnetically-assisted viral transduction (magnetofection) medical applications : An update
- 2023
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In: Biomaterials Advances. - : Elsevier BV. - 2772-9516 .- 2772-9508. ; 154
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Research review (peer-reviewed)abstract
- Gene therapy involves replacing a faulty gene or adding a new gene inside the body's cells to cure disease or improve the body's ability to fight disease. Its popularity is evident from emerging concepts such as CRISPR-based genome editing and epigenetic studies and has been moved to a clinical setting. The strategy for therapeutic gene design includes; suppressing the expression of pathogenic genes, enhancing necessary protein production, and stimulating the immune system, which can be incorporated into both viral and non-viral gene vectors. Although non-viral gene delivery provides a safer platform, it suffers from an inefficient rate of gene transfection, which means a few genes could be successfully transfected and expressed within the cells. Incorporating nucleic acids into the viruses and using these viral vectors to infect cells increases gene transfection efficiency. Consequently, more cells will respond, more genes will be expressed, and sustained and successful gene therapy can be achieved. Combining nanoparticles (NPs) and nucleic acids protects genetic materials from enzymatic degradation. Furthermore, the vectors can be transferred faster, facilitating cell attachment and cellular uptake. Magnetically assisted viral transduction (magnetofection) enhances gene therapy efficiency by mixing magnetic nanoparticles (MNPs) with gene vectors and exerting a magnetic field to guide a significant number of vectors directly onto the cells. This research critically reviews the MNPs and the physiochemical properties needed to assemble an appropriate magnetic viral vector, discussing cellular hurdles and attitudes toward overcoming these barriers to reach clinical gene therapy perspectives. We focus on the studies conducted on the various applications of magnetic viral vectors in cancer therapies, regenerative medicine, tissue engineering, cell sorting, and virus isolation.
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| 5. |
- Hamed, Ahmed, et al.
(author)
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W-Band Graphene-Based Six-Port Receiver
- 2018
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In: IEEE Microwave and Wireless Components Letters. - 1558-1764 .- 1531-1309. ; 28:4, s. 347-349
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Journal article (peer-reviewed)abstract
- We demonstrate a full-fledged millimeter-wave graphene-based six-port receiver frontend at 90 GHz employing graphene power detectors. Exploiting the high responsivity and wide dynamic range reported for the state-of-the-art graphene field-effect transistors (GFETs), graphene power detectors are demonstrated beyond the maximum oscillation frequency, f max , of the graphene transistor. The proposed circuit is fabricated on thinned SiC substrate and its functionality is verified by demodulation of 10-Mbps ON-OFF keying (OOK) digitally modulated signal.
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| 6. |
- Micah, Angela E., et al.
(author)
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Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
- 2021
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In: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
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Research review (peer-reviewed)abstract
- Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 7. |
- Abbafati, Cristiana, et al.
(author)
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- 2020
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Journal article (peer-reviewed)
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