↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Orfanos Phlippos) "

Search: WFRF:(Orfanos Phlippos)

Result 1-1 of 1

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Stepien, Magdalena, et al. (author) Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans 2017 In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 116:5, s. 688-696 Journal article (peer-reviewed)abstract BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.RESULTS: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.CONCLUSIONS: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-1 of 1

Refine your search

Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Peeters, Petra H (1); Tjønneland, Anne (1); Overvad, Kim (1); Boutron-Ruault, Mari ... (1); Trichopoulou, Antoni ... (1); Tumino, Rosario (1); show more...; Barricarte, Aurelio (1); Khaw, Kay-Tee (1); Wareham, Nick (1); Weiderpass, Elisabet ... (1); Travis, Ruth C (1); Katzke, Verena (1); Kühn, Tilman (1); Lasheras, Cristina (1); Huerta, José Maria (1); Palli, Domenico (1); Panico, Salvatore (1); Ohlsson, Bodil (1); Cross, Amanda J. (1); Freisling, Heinz (1); Hughes, David J. (1); Sieri, Sabina (1); Ricceri, Fulvio (1); Jenab, Mazda (1); Aleksandrova, Krasim ... (1); Shungin, Dmitry (1); Bamia, Christina (1); Lagiou, Pagona (1); Dorronsoro, Miren (1); Werner, Mårten (1); Stepien, Magdalena (1); Sjöberg, Klas (1); Schomburg, Lutz (1); Bueno-de-Mesquita, H ... (1); His, Mathilde (1); Affret, Aurélie (1); Bonet Bonet, Catalin ... (1); Hybsier, Sandra (1); Molina-Portillo, Ele ... (1); Orfanos, Phlippos (1); show less...

University: Umeå University (1); Lund University (1); Karolinska Institutet (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2017 (1)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view