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| 2. |
- Bousquet, Jean, et al.
(author)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Research review (peer-reviewed)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 3. |
- Cárdenas, Paco, 1976-, et al.
(author)
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From marine caves to the deep sea, a new look at Caminella (Demospongiae, Geodiidae) in the Atlanto-Mediterranean region
- 2018
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In: Zootaxa. - : Magnolia Press. - 1175-5326 .- 1175-5334. ; 4466:1, s. 174-196
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Journal article (peer-reviewed)abstract
- Caminella Lendenfeld, 1894 is a poorly known Geodiidae genus with unclear phylogenetic relationships. In order to find new lines of evidence that could shed light on the evolutionary history of Caminella, we decided to revise type material and museum material, as well as examine new material from underwater caves and deep-sea ecosystems. In doing so, we formally show that Isops maculosus Vosmaer, 1894 and Caminella loricata Lendenfeld, 1894 are junior synonyms of Caminella intuta (Topsent, 1892). We discuss different spicule morphological phenotypes in C. intuta, which may be linked to silica availability. We also discovered two new species of deep-sea Caminella: 1) from Cape Verde (Caminella caboverdensis sp. nov.) and 2) from seamounts located south of the Azores archipelago and the North of Spain (Caminella pustula sp. nov.). We reveal that Caminella sterrasters have complex surface microstructures, unique amongst the Geodiidae, where actin tips are linked to each other. Molecular markers (COI, 28S (C1-D2) and 18S) sequenced for some specimens led to new phylogenetic analyses, which continue to suggest a close relationship of Caminella with the Erylinae and Calthropella; these affinities are discussed in light of morphological characters.
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| 4. |
- Cárdenas, Paco, et al.
(author)
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Sponge Systematics Facing New Challenges
- 2012
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In: Advances in Marine Biology. - 0065-2881 .- 2162-5875. ; 61, s. 79-209
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Research review (peer-reviewed)abstract
- Systematics is nowadays facing new challenges with the introduction of newconcepts and new techniques. Compared to most other phyla, phylogenetic relationships among sponges are still largely unresolved. In the past 10 years,the classical taxonomy has been completely overturned and a review of thestate of the art appears necessary. The field of taxonomy remains a prominent discipline of sponge research and studies related to sponge systematics werein greater number in the Eighth World Sponge Conference (Girona, Spain,September 2010) than in any previous world sponge conferences. To understand the state of this rapidly growing field, this chapter proposes to review studies, mainly from the past decade, in sponge taxonomy, nomenclature andphylogeny. In a first part, we analyse the reasons of the current success of this field. In a second part, we establish the current sponge systematics theoretical framework,with the use of (1) cladistics, (2) different codes of nomenclature (Phylo-Code vs. Linnaean system) and (3) integrative taxonomy. Sponges are infamous for their lack of characters. However, by listing and discussing in a third part all characters available to taxonomists, we show how diverse characters are and that new ones are being used and tested, while old ones should be revisited.We then review the systematics of the four main classes of sponges (Hexactinellida, Calcispongiae, Homoscleromorpha and Demospongiae), each time focusing on current issues and case studies. We present a review of the taxonomic changes since the publication of the Systema Porifera (2002), and point to problems a sponge taxonomist is still faced with nowadays. To conclude,we make a series of proposals for the future of sponge systematics. In the light of recent studies, we establish a series of taxonomic changes that the sponge community may be ready to accept. We also propose a series of sponge new names and definitions following the PhyloCode. The issue of phantom species (potential new species revealed by molecular studies) is raised, and we show how they could be dealt with. Finally, we present a general strategy to help us succeed in building a Porifera tree along with the corresponding revised Porifera classification.
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| 5. |
- Folkeson, Lennart, 1950-, et al.
(author)
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Assessment of some indicators within an impact
- 2010
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In: Indicators of environmental sustainability in transport. - Bron : INRETS. ; , s. 141-189
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Book chapter (other academic/artistic)abstract
- The chapter 5 'Assessment of some indicators within an impact' looks in detail at indicators for seven impacts on the environment: direct toxicity of air pollutants, natural habitat fragmentation, non-renewable resource use, loss of cultural heritage due to land take, noise as annoyance to humans, greenhouse effect, and waste. A review of potential indicators for each impact is undertaken using criteria and other elements provided in chapter 4 as a basic framework.
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| 6. |
- Martel-Duguech, Luciana Maria, et al.
(author)
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ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.
- 2021
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In: European journal of endocrinology. - 1479-683X. ; 184:2, s. 323-334
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Journal article (peer-reviewed)abstract
- Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform.1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of healthcare professionals about AGHD.On-line survey in endocrine centres throughout Europe.Endocrinologists voluntarily completed an electronic questionnaire regarding AGHD patients diagnosed or treated in 2017-2018.Twenty-eight centres from 17 European countries participated, including 2139 AGHD patients, 28% of childhood-onset GHD. Aetiology was most frequently non-functioning pituitary adenoma (26%), craniopharyngioma (13%) and genetic/congenital mid-line malformations (13%). Diagnosis of GHD was confirmed by a stimulation test in 52% (GHRH+arginine, 45%; insulin-tolerance, 42%, glucagon, 6%; GHRH alone and clonidine tests, 7%); in the remaining, ≥3 pituitary deficiencies and low serum IGF-I were diagnostic. Initial GH dose was lower in older patients, but only women <26 years were prescribed a higher dose than men; dose titration was based on normal serum IGF-I, tolerance and side-effects. In one country, AGHD treatment was not approved. Full public reimbursement was not available in four countries and only in childhood-onset GHD in another. AGHD awareness was low among non-endocrine professionals and healthcare administrators. Postgraduate AGHD curriculum training deserves being improved.Despite guideline recommendations, GH replacement in AGHD is still not available or reimbursed in all European countries. Knowledge among professionals and health administrators needs improvement to optimize care of adults with GHD.
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| 7. |
- Ortega, Pablo, et al.
(author)
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Improving Arctic Weather and Seasonal Climate Prediction : Recommendations for Future Forecast Systems Evolution from the European Project APPLICATE
- 2022
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In: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 103:10, s. E2203-E2213
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Journal article (peer-reviewed)abstract
- The Arctic environment is changing, increasing the vulnerability of local communities and ecosystems, and impacting its socio-economic landscape. In this context, weather and climate prediction systems can be powerful tools to support strategic planning and decision-making at different time horizons. This article presents several success stories from the H2020 project APPLICATE on how to advance Arctic weather and seasonal climate prediction, synthesizing the key lessons learned throughout the project and providing recommendations for future model and forecast system development.
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| 8. |
- Weber, Werner, et al.
(author)
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The EMC2 Project on Embedded Microcontrollers: Technical Progress after two years
- 2016
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Conference paper (other academic/artistic)abstract
- Since April 2014 the Artemis/ECSEL project EMC2 is running and provides significant results. EMC2 stands for “Embedded Multi-Core Systems for Mixed Criticality Applications in Dynamic and Changeable Real-Time Environments”. In this paper we report recent progress on technical work in the different workpackages and use cases. We highlight progress in the research on system architecture, design methodology, platform and operating systems, and in qualification and certification. Application cases in the fields of automotive, avionics, health care, and industry are presented exploiting the technical results achieved.
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| 9. |
- Wunderlich, Kirsten, et al.
(author)
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Altered Expression of Metallothionein-I and -II and Their Receptor Megalin in Inherited Photoreceptor Degeneration
- 2010
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In: Investigative Ophthalmology & Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783. ; 51:9, s. 4809-4820
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Journal article (peer-reviewed)abstract
- PURPOSE. To examine in rodent models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons. METHODS. Gene and protein expression were analyzed in retinas of rd1 and rds mice and in those of RCS (Royal College of Surgeons) rats of various ages. Glial cell markers (cellular retinaldehyde binding protein, CRALBP; glial fibrillary acidic protein, GFAP; CD11b; and isolectin B4) were used to establish the identity of the cells. RESULTS. Metallothionein-I and -II gene expression increased with age in normal and degenerating retinas and was significantly greater in the latter. Protein expression, corresponding to metallothionein-I + II, was first observed in rd1 mice in Muller cells at postnatal day (P) 12 and in rds mice at P16, coinciding with the onset of GFAP expression in these cells. In RCS rats, the same distribution was observed, but not until P32, long after the onset of GFAP expression. Metallothionein-I + II was observed also in a small number of microglial cells. Megalin was expressed in the nerve fiber layer and in the region of the inner and outer segments in normal animals, but expression in the outer retina was lost with age in degenerating retinas. CONCLUSIONS. Induction of metallothionein-I and -II occurs in the RP models studied and correlates with glial activation. The progressive loss of megalin suggests that transport of metallothionein- I + II into the degenerating photoreceptors (from e.g., Muller cells), could be impaired, potentially limiting the actions of these metallothioneins. (Invest Ophthalmol Vis Sci. 2010;51:4809 -4820) DOI:10.1167/iovs.09-5073
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| 10. |
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- 2019
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Journal article (peer-reviewed)
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